Navigation Links
Stem cell finding could advance immunotherapy for lung cancer
Date:11/13/2012

CINCINNATIA University of Cincinnati (UC) Cancer Institute lung cancer research team reports that lung cancer stem cells can be isolatedand then grownin a preclinical model, offering a new avenue for investigating immunotherapy treatment options that specifically target stem cells.

John C. Morris, MD, and his colleagues report their findings in the Nov. 13, 2012, issue of PLOS One, a peer-reviewed online publication that features original research from all disciplines within science and medicine.

Stem cells are unique cells that can divide and differentiate into specialized cells typesfor example cardiac muscle or liver tissue. These cells also have the ability to self-renew and produce more stem cells.

"Increasing evidence supports the idea that cancerous tumors have a population of stem cells, also called cancer-initiating cells, that continually regenerate and fuel cancer growth," explains Morris, senior author of the study and professor at the UC College of Medicine. "These cancer stem cells may also have the highest potential to spread to other organs."

Current models used to study cancer stem cells provide limited information on the interaction between cancer stem cells with the immune system, making the study of new therapies that utilize the body's immune system to fight off cancer virtually impossible.

In this study, the UC team set out to find a viable, consistent way to isolate lung cancer stem cells that could be used in a mouse model with full immune system function. The team was able to achieve this using a functional laboratory test known as "tumorsphere" assay.

The testwhich shows how cells grow in cultureallowed them to enrich for cancer stem cells.

"Studying these unique cells could greatly improve our understanding of lung cancer's origins and lead to the novel therapeutics targeting these cells and help to more effectively eradicate this disease," adds Morris. "Immuno
'/>"/>

Contact: Amanda Harper
amanda.harper@uc.edu
513-558-4657
University of Cincinnati Academic Health Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Verinata Health Announces New Findings At The American Society Of Human Genetics
2. New findings on gene regulation and bone development
3. Finding triggers of birth defects in an embryo heart
4. One click away: Finding data on Floridas endangered species just got easier
5. New findings on protein misfolding
6. Finding new research frontiers in a single cell
7. Team discovers reason that male moths can keep finding females
8. BGI reports the latest finding on NMNAT1 mutations linked to Leber congenital amaurosis
9. Blue Ribbon Panel unveils findings on logistical improvements to support Antarctic science
10. ACRG and BGI report findings from genomics research on recurrent hepatitis B virus integration
11. UMD finding may hold key to Gaia hypothesis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... 19, 2014 Nxt-ID, Inc. (Nasdaq: NXTD ... on the growing m-commerce market, updates the "Wocket in Your Pocket" ... lightweight and light middleweight weight classes, Vinny Pazienza (PAZ). ... that Game of Thrones actor Ciaran Hinds ... star Katey Sagal have been cast in ...
(Date:9/18/2014)... - Washington State University researchers have developed a unique ... power waste cleanup in rural areas. , The ... an inexpensive and quick way to clean up waste ... while reducing pollution. , Professor Haluk Beyenal and ... Engineering and Architecture discuss the system in the online ...
(Date:9/18/2014)... located deep in the primitive brainstem has revealed how ... Harvard School of Medicine and the University at Buffalo ... the second "sleep node" identified in the mammalian brain ... to produce deep sleep. , Published online in August ... fully half of all of the brain,s sleep-promoting activity ...
Breaking Biology News(10 mins):NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 2NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 3Researchers develop unique waste cleanup for rural areas 2No sedative necessary: Scientists discover new 'sleep node' in the brain 2
... combined genetic and geographic data of the H5N1 avian ... decade. They found that multiple strains of the virus ... identified many of the migration routes through which the ... H5N1 strains develop and migrate, health officials can better ...
... brewing about whether pre-Columbian Amazonian populations settled in large ... that many conservationists take to be ‘natural.' , This ... and is challenged in a recent paper from Dr. ... findings of Bush’s research may rekindle a debate has ...
... genes from an ancient wheat variety have led to a ... recent set of papers published in the journal Plant Physiology ... Nax2. The genes work by excluding salt from different parts ... the leaves. The discovery of the two genes is the ...
Cached Biology News:UCI scientists reconstruct migration of avian flu virus 2Paper challenges 1491 Amazonian population theories 2Paper challenges 1491 Amazonian population theories 3Paper challenges 1491 Amazonian population theories 4Ancient genes used to produce salt-tolerant wheat 2
(Date:9/20/2014)... 2014 HealthTronics, Inc. , ... radiology products and services, has signed a distribution ... Clinicon Corporation for its high precision laser ... minimally invasive, mobile, surgical technology—offering more choices for ... agreement, HealthTronics will make available Clinicon’s FDA-cleared SureLase™ ...
(Date:9/19/2014)... crop yields to disease risks, the biological characteristics people ... Just as for heightthe textbook example of a complex ... shaped by multiple genetic and environmental influences, making it ... such genes, geneticists typically mate two individuals that differ ... small mouseand then study their descendents, looking for genes ...
(Date:9/19/2014)... (PRWEB) September 19, 2014 ... its potential to revolutionize the world has attracted ... corporations and small start-ups. The early years of ... projects largely due to the high risks involved, ... budgets earmarked for this evolving technology have been ...
(Date:9/19/2014)... 2014  Nektar Therapeutics (NASDAQ: NKTR ... the analgesic profiles of a series of the ... molecules. The preclinical research candidates were created using ... The analgesic properties of kappa receptor agonism ... Kappa opioid receptors are expressed in the ...
Breaking Biology Technology:HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 2HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 3Want to link genes to complex traits? Start with more diversity 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 3Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 4Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 2Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 3Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 4Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 5
... Hammer LLC , a software company in Waukesha that sells ... design programs, said on Thursday it has been acquired by ... announced it would expand its offerings to manufacturers and retailers ... products, and product pictures. Big Hammer operates one of 11 ...
... of research in the history of the University of ... its image from a university of access to a ... build a knowledge-based economy. , ,Abbas Ourmazd, keynote speaker ... Awards, appealed for support for UWMs Research Growth Initiative. ...
... said on Tuesday that a patent it has just ... property in the U.S. , ,The patent covers a combination ... a type of chain reaction that makes copies of DNA ... its existing Invader chemistry. , ,"These important, new patents are ...
Cached Biology Technology:Tech awards keynoter asks for support of UWM transformation 2Tech awards keynoter asks for support of UWM transformation 3
For use with SSP products or any application requiring agarose gel separation • Multiple formats available to meet various throughput needs • Includes replacement parts for each un...
recombination at attR1 and attR2 sites...
...
GlutaMAX-I Supplement...
Biology Products: