Navigation Links
Stem cell 'daughters' lead to breast cancer
Date:8/2/2009

e women are often limited to chemotherapy and radiotherapy, so identifying new treatment and prevention strategies is a priority for us," he said.

Luminal progenitor cells in women with BRCA1 mutations have 'forgotten' how to behave, Dr Lindeman said. "Usually, luminal progenitor cells multiply rapidly in the presence of certain growth factors. In BRCA1 women these cells don't even require growth factors to proliferate they misbehave from the outset.

"We also know that the BRCA1 gene is required for normal DNA repair. There may therefore be a triple whammy effect faulty growth control, faulty DNA repair and expanded luminal progenitor cell numbers ultimately resulting in breast cancer in some BRCA1 mutation carriers."

Dr Visvader said in the long-term, breast biopsies might be able to reveal misbehaving luminal progenitor cells. What's more, certain 'markers' might one day help guide diagnosis and treatment. "For example, c-KIT is a key marker of the luminal progenitor cell and I expect we will see an increase in pathologists routinely using this as a diagnostic marker for basal-like tumours," she said. "It may even be possible to develop new drugs that target c-KIT, since drugs are already available that target different forms of this marker."

Dr Lindeman said the identification of stem cells, luminal progenitor cells and other cell types in the breast was now beginning to reveal a breast cancer roadmap - highlighting cancer-prone cell types and key genetic pathways. "Hopefully this will lead to new, tailored therapies for the next generation of women."

Dr Visvader said the research had only been possible through the generous donation of breast tissue by women undergoing breast surgery, together with the support of their surgeons and pathologists. The study was facilitated by the Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer.


'/>"/>

Contact: Penny Fannin
fannin@wehi.edu.au
61-393-452-345
Walter and Eliza Hall Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Possible drug target found for one of the most aggressive breast cancers
2. Genetic factors implicated in survival gap for breast, ovarian or prostate cancer
3. New MRI technique could mean fewer breast biopsies in high-risk women
4. Protein linked to change in tissue that surround and support breast tumors
5. Dual role in breast tissue for a protein involved in leukemia
6. Dioxins in food chain linked to breastfeeding ills
7. Wet ear wax and unpleasant body odors signal breast cancer risk
8. Breastfeeding duration and weaning diet may shape childs body composition
9. Lombardi scientist brings dream team breast cancer research effort to GUMC
10. Genetic testing for breast or ovarian cancer risk may be greatly underutilized
11. UNC study identifies genetic cause of most common form of breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stem cell 'daughters' lead to breast cancer
(Date:12/22/2014)... Dec. 22, 2014 Research and Markets ... the "The Global Watermarking and Fingerprinting Markets" ... http://photos.prnewswire.com/prnh/20130307/600769 This insight ... watermarking and fingerprinting markets. Watermarking aims to control ...
(Date:12/19/2014)... VIEW, Calif. , Dec. 18, 2014  23andMe, Inc., the ... study that pinpoints fine-scale differences in genetic ancestry of individuals ... Since immigrants first arrived more than four hundred years ... as a meeting place for peoples from different continents. This ...
(Date:12/17/2014)... 15, 2014  HITLAB SM announced today its completion ... its adherence to current U.S. Food and Drug Administration ... smart device and smart phone application trials utilizing the ... "HITLAB is determined to improve global healthcare access, ...
Breaking Biology News(10 mins):The Global Watermarking and Fingerprinting Markets 223andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2
... of Toronto-based researchers may be one step closer to a ... research and therapy. Induced pluripotent stem cells (iPSCs) can ... flexibly develop into many different types of cells. However, producing ... generation are largely unknown. But researchers from the University ...
... CHARGE syndrome* is a severe developmental disorder affecting multiple ... majority of patients carry a mutation in a gene ... broad spectrum of characteristic CHARGE symptoms has been a ... an important class of epigenetic regulators. DNA is wound ...
... that causes tuberculosis (TB) varies between patients of different ... tests to diagnose and monitor treatment for the disease, ... PLOS Pathogens . , The study, led by ... with the Medical Research Council,s National Institute for Medical ...
Cached Biology News:Toronto team ID proteins key in stem cell production 2Exercise rescues mutated neural stem cells 2Exercise rescues mutated neural stem cells 3Scientists discover ethnic differences in immune response to TB bacterium 2Scientists discover ethnic differences in immune response to TB bacterium 3
(Date:1/22/2015)... GEA Niro Soavi the leader in high ... PandaPLUS 2000, which is ideal for new applications for ... disruption . This compact laboratory homogenizer is the perfect ... food additives and ingredients as well as for the ...
(Date:1/22/2015)... Boulder, CO / Rootstown, OH (PRWEB) January 22, 2015 ... sensitive detection platform, announced today that it has received AOAC-PTM ... O26, O45, O1O3, O111, O121, and O145; collectively referred to ... (E. coli) O157, at 1 colony forming unit (cfu) per ...
(Date:1/22/2015)... January 22, 2015 Selexis SA, a ... Research Cell Banks (RCBs) used for drug discovery to ... Banks will include Next-Generation Sequencing (NGS) data ... de-risks biologic manufacturing by ensuring the integrity of the ...
(Date:1/22/2015)... , Jan. 22, 2015   GenoSpace , a precision ... tools to enable the broad use of genomic, imaging and ... the appointment of Michelle Munson , CEO of Aspera, ... Logo - http://photos.prnewswire.com/prnh/20150122/170713 ...
Breaking Biology Technology:GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2GenoSpace Expands Board with Appointment of Michelle Munson 2
... Direct and indirect sales momentum gathers for the ... Feb. 28 /PRNewswire/ - Touch,Bionics, developer of the ... Prosthetic Supply) the leading U.S. O&P distributor today,announced ... distribution agreement for,the i-LIMB Hand in the United ...
... 28 PAREXEL International,Corporation (Nasdaq: PRXL ) ... James 29th Annual Institutional Investors Conference at the ... Senior Vice,President and Chief Financial Officer will be ... ET on Monday, March 3, 2008., A ...
... Microchip Biotechnologies, Inc.,(MBI) is collaborating with ... sample preparation system to generate template libraries,for ... project is to automate,the complex, multi-step upstream ... Pyrosequencing. "Using,MBI,s MOV technology to develop and ...
Cached Biology Technology:Touch Bionics signs U.S. distribution agreement with SPS 2PAREXEL International to Present at Raymond James 29th Annual Institutional Investors Conference 2Microchip Biotechnologies, Inc. Collaborating With Stanford University on Developing a Front End Microfluidic-Based Sample Preparation System for Pyrosequencing Platforms 2
TP-1 (NDOG1)...
Mouse monoclonal [6G11] to Cytohesin 1 + 2 ( Abpromise for all tested applications)....
HP 1 alpha Immunogen: Synthetic peptide between amino acids 1-100 of the human HP 1 alpha protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
... Immunogen KLH-conjugated, synthetic ... 54-75 (RRGPHRNPG-PGDDDGQRSRSSS) of mouse p19ARF. ... to amino acids 62-75. Clone ... Routinely evaluated by immunoblot. ...
Biology Products: