Navigation Links
Stem cell 'daughters' lead to breast cancer
Date:8/2/2009

e women are often limited to chemotherapy and radiotherapy, so identifying new treatment and prevention strategies is a priority for us," he said.

Luminal progenitor cells in women with BRCA1 mutations have 'forgotten' how to behave, Dr Lindeman said. "Usually, luminal progenitor cells multiply rapidly in the presence of certain growth factors. In BRCA1 women these cells don't even require growth factors to proliferate they misbehave from the outset.

"We also know that the BRCA1 gene is required for normal DNA repair. There may therefore be a triple whammy effect faulty growth control, faulty DNA repair and expanded luminal progenitor cell numbers ultimately resulting in breast cancer in some BRCA1 mutation carriers."

Dr Visvader said in the long-term, breast biopsies might be able to reveal misbehaving luminal progenitor cells. What's more, certain 'markers' might one day help guide diagnosis and treatment. "For example, c-KIT is a key marker of the luminal progenitor cell and I expect we will see an increase in pathologists routinely using this as a diagnostic marker for basal-like tumours," she said. "It may even be possible to develop new drugs that target c-KIT, since drugs are already available that target different forms of this marker."

Dr Lindeman said the identification of stem cells, luminal progenitor cells and other cell types in the breast was now beginning to reveal a breast cancer roadmap - highlighting cancer-prone cell types and key genetic pathways. "Hopefully this will lead to new, tailored therapies for the next generation of women."

Dr Visvader said the research had only been possible through the generous donation of breast tissue by women undergoing breast surgery, together with the support of their surgeons and pathologists. The study was facilitated by the Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer.


'/>"/>

Contact: Penny Fannin
fannin@wehi.edu.au
61-393-452-345
Walter and Eliza Hall Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Possible drug target found for one of the most aggressive breast cancers
2. Genetic factors implicated in survival gap for breast, ovarian or prostate cancer
3. New MRI technique could mean fewer breast biopsies in high-risk women
4. Protein linked to change in tissue that surround and support breast tumors
5. Dual role in breast tissue for a protein involved in leukemia
6. Dioxins in food chain linked to breastfeeding ills
7. Wet ear wax and unpleasant body odors signal breast cancer risk
8. Breastfeeding duration and weaning diet may shape childs body composition
9. Lombardi scientist brings dream team breast cancer research effort to GUMC
10. Genetic testing for breast or ovarian cancer risk may be greatly underutilized
11. UNC study identifies genetic cause of most common form of breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stem cell 'daughters' lead to breast cancer
(Date:7/13/2015)... , Jul. 13, 2015 NXT-ID, Inc. ... a biometric authentication company focused on the growing ... filed provisional patent 62/188684 for BEHAVIORAL-DIRECTED ... another new convenient and secure method to make ... innovative payment methods, introduced with its groundbreaking voice-direct ...
(Date:7/9/2015)... Calif. , July 9, 2015 /PRNewswire/ ... leading developer of human interface solutions, today ... the industry,s first fully hardware encapsulated fingerprint ... secure authentication technology is literally off the ... and biometric matching within the fingerprint sensor ...
(Date:7/8/2015)... Florida , July 8, 2015 ... evolving as this summer,s must have products such as wearables, ... demand as popularity for biometrics based devices continues to rapidly ... NXT-ID, Inc. (NASDAQ: NXTD ), Google Inc. (NASDAQ: ... (NYSE: FIT ), GoPro, Inc. (NASDAQ: GPRO ) ...
Breaking Biology News(10 mins):NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 2Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 3Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 4Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 5Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 6
... argue for a shift toward practices that use ... recycling of energy and materials, according to an ... BioScience. The author, Craig J. Pearson of the ... -- which he terms "regenerative" -- could enhance ...
... Ecology and the Environment explores ecology in an era ... production systems, and invasive species on ecosystems and people ... throughout the Americas gathered last year in Merida Mexico ... following are highlights from the meeting, including more extensive ...
... May 2nd issue of the online, open-access journal PLoS ONE, ... southern Madagascar, there are also large areas of forests regenerating. ... in the study area, with an overall net increase of ... the highest level of plant endemism (species found only in ...
Cached Biology News:Ecology in an era of globalization 2Madagascan tropical forests return thanks to better management and well-defined ownership 2
(Date:8/3/2015)... , Aug. 3, 2015  Merck KGaA, Darmstadt, ... and top-quality high-tech products in the healthcare, life science ... US-based company Nano-C, their development and launch of promising ... photovoltaics (OPV). Merck KGaA, Darmstadt, Germany ... growing OPV sector. Novel derivatives: highly stable, ...
(Date:8/3/2015)... 2015  Aethlon Medical, Inc. (Nasdaq: AEMD ), ... life-threatening diseases, today announced that it will host its ... on Thursday, August 13, 2015 at 4:30 p.m. Eastern ... the release of fiscal 2016 first quarter results.  A ... two hours after the call at the Investor Relations ...
(Date:8/3/2015)... GERMANTOWN, Md. , Aug. 3, 2015   ... it will release first half and second quarter 2015 ... 10 th , 2015.  The Company will host a ... results and provide a general business update. ... (Domestic US) and 1-412-902-4262 (International), and asking to join ...
(Date:8/3/2015)... - RepliCel Life Sciences Inc. (TSX.V: RP) (OTCQB: REPCF), a ... autologous cell therapies, announced today that RepliCel,s CEO, David ... in Minneapolis, Minnesota on August 5 ... highlight RepliCel,s 18-month milestones including CE Mark for its RCI-02 ... clinical data from both RCT-01 (tendon) and RCS-01 (skin) clinical ...
Breaking Biology Technology:Merck KGaA, Darmstadt, Germany, and Nano-C Present Enhanced Materials for Organic Photovoltaics 2Merck KGaA, Darmstadt, Germany, and Nano-C Present Enhanced Materials for Organic Photovoltaics 3Merck KGaA, Darmstadt, Germany, and Nano-C Present Enhanced Materials for Organic Photovoltaics 4Aethlon Medical To Host First Quarter Fiscal 2016 Investor Call on August 13, 2015 2Intrexon to Announce First Half and Second Quarter 2015 Financial Results and Host Conference Call on August 10th 2RepliCel Presenting at InvestMNT Investor Conference in Minneapolis 2
... Minn., March 3, 2011 Executive search firm Sanford ... of a key search engagement for Nordson Corporation: Lise ... operation, a leading provider of biomaterial applicators used in ... Micromedics with over 20 years of experience in the ...
... OmniComm Systems, Inc. (OTC Bulletin Board: ... the EDC marketplace, today announced that its TrialOne suite ... Trials (WCCT) to automate their clinical trial operations and ... by WCCT ends an exhaustive search to find technologies ...
... 2011 Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) ... of Neurocrine Biosciences, will be presenting at the Cowen & ... The live presentation takes place on Wednesday, March 9, 2011 ...  The presentation will be webcast and may be accessed on ...
Cached Biology Technology:Sanford Rose Associates® - Minneapolis Fills Key Management Position for the Micromedics Operation of Nordson Corporation 2West Coast Clinical Trials Selects OmniComm Systems' TrialOne® Suite to Automate Phase I Clinic Operations 2West Coast Clinical Trials Selects OmniComm Systems' TrialOne® Suite to Automate Phase I Clinic Operations 3
... The active ingredient in Molecular Probes. ... appears to act as a free ... emission. Our original SlowFade formulation (S-2828) ... rate of fluorescein to almost zero ...
... Dual-Binary Analytical System more than doubles the ... LC/MS. The fast analysis cycles of the ... to 100% in tandem mode. Difficult separations ... Using backflush or heartcut configurations, on-line sample ...
... The PerkinElmer kit provides reagents for ... in serum and plasma samples using a ... samples are then neutralized and transferred to ... highly specific mouse monoclonal antibody to HIV-1 ...
Request Info...
Biology Products: