Navigation Links
Stem cell 'daughters' lead to breast cancer
Date:8/2/2009

e women are often limited to chemotherapy and radiotherapy, so identifying new treatment and prevention strategies is a priority for us," he said.

Luminal progenitor cells in women with BRCA1 mutations have 'forgotten' how to behave, Dr Lindeman said. "Usually, luminal progenitor cells multiply rapidly in the presence of certain growth factors. In BRCA1 women these cells don't even require growth factors to proliferate they misbehave from the outset.

"We also know that the BRCA1 gene is required for normal DNA repair. There may therefore be a triple whammy effect faulty growth control, faulty DNA repair and expanded luminal progenitor cell numbers ultimately resulting in breast cancer in some BRCA1 mutation carriers."

Dr Visvader said in the long-term, breast biopsies might be able to reveal misbehaving luminal progenitor cells. What's more, certain 'markers' might one day help guide diagnosis and treatment. "For example, c-KIT is a key marker of the luminal progenitor cell and I expect we will see an increase in pathologists routinely using this as a diagnostic marker for basal-like tumours," she said. "It may even be possible to develop new drugs that target c-KIT, since drugs are already available that target different forms of this marker."

Dr Lindeman said the identification of stem cells, luminal progenitor cells and other cell types in the breast was now beginning to reveal a breast cancer roadmap - highlighting cancer-prone cell types and key genetic pathways. "Hopefully this will lead to new, tailored therapies for the next generation of women."

Dr Visvader said the research had only been possible through the generous donation of breast tissue by women undergoing breast surgery, together with the support of their surgeons and pathologists. The study was facilitated by the Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer.


'/>"/>

Contact: Penny Fannin
fannin@wehi.edu.au
61-393-452-345
Walter and Eliza Hall Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Possible drug target found for one of the most aggressive breast cancers
2. Genetic factors implicated in survival gap for breast, ovarian or prostate cancer
3. New MRI technique could mean fewer breast biopsies in high-risk women
4. Protein linked to change in tissue that surround and support breast tumors
5. Dual role in breast tissue for a protein involved in leukemia
6. Dioxins in food chain linked to breastfeeding ills
7. Wet ear wax and unpleasant body odors signal breast cancer risk
8. Breastfeeding duration and weaning diet may shape childs body composition
9. Lombardi scientist brings dream team breast cancer research effort to GUMC
10. Genetic testing for breast or ovarian cancer risk may be greatly underutilized
11. UNC study identifies genetic cause of most common form of breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stem cell 'daughters' lead to breast cancer
(Date:10/18/2014)... Berlin, 19th October 2014 Psychological stress and stress-related ... for aging-related diseases, but the molecular mechanisms ... mechanisms may contribute to the development of ... treatments for these devastating diseases. This work ... Neuropsychopharmacology congress in Berlin., Now an international ...
(Date:10/17/2014)... – Accurate knowledge regarding Ebola is critical and pertinent ... of hazardous global outbreak and epidemic. The Journal, ... a special issue, Ebola Virus and Public Health, to ... knowledge in this critical societal moment. , On ... Ebola for Clinicians . The primer was prepared by ...
(Date:10/17/2014)... German . To ... treating overdoses, doctors are often limited to supportive therapy such ... a combination of drugs involved. So what can be done ... pills? ETH professor Jean-Christophe Leroux from the Institute of Pharmaceutical ... this question. "The task was to develop an agent that ...
Breaking Biology News(10 mins):Researchers find why depression and aging linked to increased disease risk 2Emergency aid for overdoses 2Emergency aid for overdoses 3
... have come under scrutiny lately due to adverse cardiovascular ... and rat models, researchers reveal another adverse effect of ... effect is independent of the COX-2 enzyme. ... the heart rate of Drosophila, a good model for ...
... publisher of medical and scientific books and journals, ... Press content is immediately available on www.springerlink.com ... journals and more than 22,000 eBooks. Beginning with ... may purchase Humana Press journals through Springer. All ...
... restraining elderly residents and giving them fewer sleeping pills ... 21 nursing home units published in the January issue ... led by the Karolinska Institutet, Sweden, analysed 2,343 reported ... out how they related to fall risk assessments and ...
Cached Biology News:Humana Press journals now available on SpringerLink 2Selective restraints and reduced medication could reduce nursing home falls says 4-year study 2
(Date:10/20/2014)... 2014 Local veterinary surgeon, Dr. Tim ... study of donor stem cells for dogs with osteoarthritis. ... and has performed clinical stem cell therapy for 7 ... determine if a single injection of donor stem cells ... reduce pain and inflammation in the treated joints. ...
(Date:10/19/2014)... The Asian Automatic patient billing report ... and forecast of revenue. The Automatic patient billing market ... million by 2018, at a developing CAGR of 7.2% ... of the Asian Automatic patient billing market, to get ... provides a glimpse of the segmentation of this market ...
(Date:10/19/2014)... 2014 According to market research ... WLAN Controllers; Wireless gateways)]- Global Advancements, Forecasts and ... global Outdoor Wi-Fi market with analysis and forecasting ... also identifies the drivers and the restrains for ... opportunities and challenges. , Browse 65 market data ...
(Date:10/18/2014)... The Asia-Pacific hardware encryption display market report defines and ... forecast of revenue. This market was valued $5,154.0 million ... by 2018, at a CAGR of 58.4% from 2013 ... Asia-Pacific hardware encryption market report, to get an idea ... glimpse of the segmentation of the market, and is ...
Breaking Biology Technology:Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 2Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 3Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 4The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 3
... November 2, 2011 In preparation for ... Lupus drug in 50 years, Human Genome Sciences (HGS) ... its newly formed European commercial sales team. The company ... of use, flexibility, mobility, industry-specific functionality, speed, and low ...
... month,s edition of Physics World, Paul Blom and Ton ... a way of creating thin, flexible sheets of organic ... process. These bendable materials could oust the ... our surroundings, being used for everything from lighting tiles ...
... Inc., a California based biotech company, announced today ... from the United States Patent and Trademark Office ... (application 10/705,109).  The Notice allowed 17 claims for ... using libraries of antibodies.  This method has several ...
Cached Biology Technology:Human Genome Sciences Europe Moves to the Cloud With Veeva CRM to Support New Lupus Treatment 2Human Genome Sciences Europe Moves to the Cloud With Veeva CRM to Support New Lupus Treatment 3Researchers roll out a new form of lighting 2