Navigation Links
Stem cell clues uncovered
Date:7/12/2013

Baltimore, MDProper tissue function and regeneration is supported by stem cells, which reside in so-called niches. New work from Carnegie's Yixian Zheng and Haiyang Chen identifies an important component for regulating stem cell niches, with impacts on tissue building and function. The results could have implications for disease research. It is published by Cell Stem Cell.

Lamins are proteins that the major structural component of the material that lines the inside of a cell's nucleus. Lamins have diverse functions, including suppressing gene expression. It has been difficult to understand how mutations in lamins cause diseases in specific tissues and organs, such as skeletal muscles, heart muscle, and fat.

A group of human diseases called laminopathies, which include premature aging, are caused by defects in proteins called lamins. Zheng and her team, which included Xin Chen of Johns Hopkins University, decided to examine whether lamins would link stem cell niche function to healthy tissue building and maintenance.

To understand the tissue-specific effects of lamin mutations, the team focused on fruit fly testis, one of the best-studied stem cell niche systems. In the fruit fly testis, biochemical cross-signaling between the different types of cells that make up the niche environment ensures proper maintenance and differentiation of the testis system's stem cells.

Using an advanced array of techniques available in fruit fly studies, the team demonstrated that lamins were a necessary component of supporting niche organization, which in turn regulates proper proliferation and differentiation of germline stem cells in fruit fly testis.

"These results could have implications for the role of lamins in other types of stem cell niches," Zheng said. "These findings could contribute to the study of diseases caused by lamina-based tissue degeneration. For example, different lamin mutations could disrupt the organiz
'/>"/>

Contact: Yixian Zheng
zheng@ciwemb.edu
410-246-3032
Carnegie Institution
Source:Eurekalert

Page: 1 2

Related biology news :

1. Fingernails reveal clues to limb regeneration
2. Alligator stem cell study gives clues to tooth regeneration
3. Divide and define: Clues to understanding how stem cells produce different kinds of cells
4. Clues to heart disease in unexpected places, Temple researchers discover
5. Scientists decode genome of painted turtle, revealing clues to extraordinary adaptations
6. Researcher offers clues on the origins of life
7. Acoustic monitoring of Atlantic cod reveals clues to spawning behavior
8. Computer simulations yield clues to how cells interact with surroundings
9. Clues point to cause of a rare fat-distribution disease
10. Clues to chromosome crossovers
11. USC researchers find possible genetic clues to organ development, birth defects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... pivotal in the development of cancer, viral infection and ... question about one of the most widely-researched proteins in ... of thousands of research papers and millions of pounds ... in Professor Sir Philip Cohen,s laboratory at the University ... is activated. The results are published today ...
(Date:7/9/2014)... ability to switch out one gene for another in ... from science fiction to reality within this decade. As ... promise--the hope of fixing disease-causing genes in humans, for ... scientists have put one of those concerns to rest: ... overall occurrence of mutations in the cells. The new ...
(Date:7/9/2014)... geographic ranges in which animals can be found, concern ... Does an increased range for a host mean new ... says a team of UC Santa Barbara scientists, including ... published in the Journal of Biogeography , Hechinger, ... opposite may happen: Hosts may actually lose their parasites ...
Breaking Biology News(10 mins):Research reveals how key controller protein is switched on 2No extra mutations in modified stem cells, study finds 2No extra mutations in modified stem cells, study finds 3Not at home on the range 2Not at home on the range 3Not at home on the range 4
... the humble honey bee, researchers at the University of ... understanding the molecular basis of social behavior in humans. ... a model system for social behavior," said Saurabh (pronounced ... affiliate of the university's Institute for Genomic Biology. Using ...
... Children with cancer who suffer hearing loss due to the ... get their hearing back through pharmacological and gene therapy, thanks ... Research Hospital. Mice with a variety of genetic mutations that ... understand age-related hearing loss in adults, as well as hearing ...
... cause of blindness in western society, say experts at The ... eye instrument, they have launched a study to see if ... also explain why the 77-year-old sailor has no need for ... and broccoli are rich in a chemical called lutein, which, ...
Cached Biology News:Honey bee genome holds clues to social behavior 2St. Jude finds clues to hearing loss from chemotherapy 2Why Popeye only has eyes for spinach 2
(Date:1/15/2014)... IPSWICH, England , January 15, 2014 ... to win races on the Formula 1 track could help ... between McLaren Applied Technologies (MAT), Stowhealth (a GP surgery based ... funded by healthcare provider Simplyhealth. Telemetry technology, which ...
(Date:1/15/2014)... The Microcompetition with Foreign DNA theory explains how latent viruses ... is the Epstein Barr Virus (EBV), and one of these ... chronic inflammatory disease that destroys the body’s joints. As predicted ... high concentrations of EBV DNA in their bodies (1). ...
(Date:1/15/2014)... 15, 2014 Freeslate, Inc ., ... announced that Lupin Limited, one of India’s top five ... Protégé PharmD System for high throughput solid form ... focused on a wide range of quality, affordable generic ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Date: Friday, April ... Location: Warrington Country Club, 1360 Almshouse Road, Warrington, Pa. ... nonprofit organization solely dedicated to finding a cure for hepatitis ... worldwide, will host its annual Crystal Ball on Friday, April ...
Breaking Biology Technology:Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2
... to Additional Capital Will Enable Revenue Growth, ... Bulletin Board: BLFS), a leading developer and marketer ... tissues, and organs, today announced that it reached ... to increase the Company,s,existing credit facility from $5 ...
... that NanoBio,s nanoemulsion technology is effective when ... used in therapeutic applications and vaccines, ANN ... it will present compelling new data in nine presentations ... programs,in onychomycosis, herpes labialis, cystic fibrosis and an intra-nasal,influenza ...
... NxStage Medical,Inc. (Nasdaq: NXTM ), a ... its Medisystems Division has signed a,long-term product supply ... provider of dialysis services in the United States. ... the Streamline(TM) airless,blood tubing set as well as ...
Cached Biology Technology:BioLife Solutions Credit Facility Increased to $9 Million 2NanoBio to Announce Key Clinical and Preclinical Data in Nine Presentations at ICAAC/IDSA 2008 2NxStage Announces Streamline(TM) Blood Tubing Set Supply Agreement with Renal Advantage Inc. 2NxStage Announces Streamline(TM) Blood Tubing Set Supply Agreement with Renal Advantage Inc. 3
Umbilical cord blood eosinophils, For immunohistochemistry (IHC)...
Monocyte-derived dendritic cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Dendritic Cells...
Human plasmacytoid dendritic cells, BDCA-4+, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Dendritic Cells and EPCs...
Human peripheral blood neutrophils, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Granulocytes...
Biology Products: