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Stem cell breakthrough could lead to new bone repair therapies on nanoscale surfaces
Date:2/11/2013

Scientists at the University of Southampton have created a new method to generate bone cells which could lead to revolutionary bone repair therapies for people with bone fractures or those who need hip replacement surgery due to osteoporosis and osteoarthritis.

The research, carried out by Dr Emmajayne Kingham at the University of Southampton in collaboration with the University of Glasgow and published in the journal Small, cultured human embryonic stem cells on to the surface of plastic materials and assessed their ability to change.

Scientists were able to use the nanotopographical patterns on the biomedical plastic to manipulate human embryonic stem cells towards bone cells. This was done without any chemical enhancement.

The materials, including the biomedical implantable material polycarbonate plastic, which is a versatile plastic used in things from bullet proof windows to CDs, offer an accessible and cheaper way of culturing human embryonic stem cells and presents new opportunities for future medical research in this area.

Professor Richard Oreffo, who led the University of Southampton team, explains: "To generate bone cells for regenerative medicine and further medical research remains a significant challenge. However we have found that by harnessing surface technologies that allow the generation and ultimately scale up of human embryonic stem cells to skeletal cells, we can aid the tissue engineering process. This is very exciting.

"Our research may offer a whole new approach to skeletal regenerative medicine. The use of nanotopographical patterns could enable new cell culture designs, new device designs, and could herald the development of new bone repair therapies as well as further human stem cell research," Professor Oreffo adds.

The study was funded by the Biotechnology and Biological Sciences Research Council (BBSRC).

This latest discovery expands on the close collaborative
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Contact: Becky Attwood
r.attwood@soton.ac.uk
44-023-805-95457
University of Southampton
Source:Eurekalert

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