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Stealth nanoparticles lower drug-resistant tumors' defenses
Date:10/23/2013

rapy to work. It also allows the particles to specifically bind to TNBC tumor cells. When tested in mice, the nanoparticles targeted the tumors and reduced the levels of protective proteins by nearly 80 percent. With the cancer cells rendered vulnerable, the nanoparticles' anticancer drug payload showed significantly enhanced therapeutic effects and shrunk tumors by 8-fold. The scientists state, "In summary, the results here provide a potential strategy to treat an aggressive and recurrent form of TNBC, as well as a means of adapting this platform to a broad range of controlled multi-drug therapies customizable to the cancer type in a singular nanoparticle delivery system." They also say that the "layer-by-layer" nanoparticle components are biocompatible and biodegradable, which will allow rapid translation into potential clinical benefits.


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Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1 2

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