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Statins may treat blood vessel disorder that can lead to fatal strokes
Date:1/26/2009

to the blood vessel defects seen in CCM patients. They tested their hypothesis by administering simvastatin, which is known to inhibit Rho activity, to mouse models with the Ccm2 mutations and saw that the drugs strengthened the damaged blood vessels in the mice."

Eugene Golanov, M.D., Ph.D., a program director at the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, said Li's and Whitehead's study is an important work. "By attacking this disease from many angles including genetic, biochemical and pharmacological approaches Dr. Li's team has shed new light on the mechanism of the disease and a potential drug therapy, " Golanov said. "Their success illustrates the importance of encouraging teams of scientists and physicians across institutions and disciplines to target familial stroke diseases such as cerebral cavernous malformations."


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Contact: Phil Sahm
phil.sahm@hsc.utah.edu
801-581-2517
University of Utah Health Sciences
Source:Eurekalert

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