Navigation Links
Statins may stave off septic lung damage says new research study
Date:5/2/2011

Statins may be best known for their ability to reduce cholesterol, but a research report appearing in the May 2011 issue of the Journal of Leukocyte Biology (http://www.jleukbio.org) shows that these same drugs could also play a crucial role in the reduction of lung damage resulting from severe abdominal sepsis and infection.

"We hope that this study will not only provide new knowledge about the complicated pathophysiology behind abdominal sepsis, but also form the basis for more effective and specific treatment options for patients with severe infections," said Henrik Thorlacius, M.D., Ph.D., a researcher involved in the workfrom the Department of Surgery at Skane University Hospital at Lund University, Malmo, Sweden.

To make this discovery, the researchers studied mice with a punctured intestinal bowel and treated half with a statin drug, simvastatin, and the others with only water. The animals treated with simvastatin had much less lung injury than those only given water. Additionally, the simvastatin-treated group demonstrated significantly fewer inflammatory cells in the lung, as well as reduced levels of pro-inflammatory substances. These findings suggest that treatment with statins may be of clinical value for patients with severe abdominal infections.

"Sepsis is a serious medical problem for which few good treatments exist," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology, "This research is very exciting because statins are readily available and have a well established safety profile, making them a prime candidate for efficacy testing."

According to the National Institute of General Medical Sciences, NIH, Sepsis is a major challenge in the intensive care unit, where it is one of the leading causes of death. It is caused when immune chemicals released into the blood to combat infection trigger widespread inflammation, resulting in impaired blood flow, which damages the body's organs by depriving them of nutrients and oxygen. In the worst cases, the heart weakens and multiple organslungs, kidneys, livermay quickly fail and the patient can die. Each year, severe sepsis strikes about 750,000 Americans, and as many as half die, which is more than the number of U.S. deaths from prostate cancer, breast cancer and AIDS combined.


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Study suggests statins may prevent diabetic-related blindness
2. Free statins with fast food could neutralize heart risk, scientists say
3. Statins may treat blood vessel disorder that can lead to fatal strokes
4. Statins may prevent miscarriages
5. Jekyll and Hyde: Cells executioner can also stave off death
6. Lifestyle changes may stave off diabetes for a decade
7. Drinking milk in the morning may help stave off lunchtime hunger
8. Blood-clotting protein linked to cancer and septicemia
9. Septic shock: Nitric oxide beneficial after all
10. CEL-SCI Corporation to Launch Aseptic Filling for Stem Cell Produced Therapies and Other Biological Products
11. RIT researchers help map tsunami and earthquake damage in Japan
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/1/2017)...  Aware, Inc. (NASDAQ: AWRE), a leading supplier of ... Moberg has resigned, effective March 3, 2017, as ... and Treasurer of Aware citing a desire to retire.  ... of the Board of Directors of Aware. ... and co-President, General Counsel has been named Chief Executive ...
(Date:2/26/2017)... -- Securus Technologies, a leading provider of civil and ... corrections and monitoring, announces the appointment of a ... often, too many offenders return to jail or ... to tackle this ongoing problem and improve the ... significant steps are underway, Securus continues to invest ...
(Date:2/16/2017)... , Feb. 16, 2017  Genos, a ... announced that it has received Laboratory Accreditation from ... Accreditation is presented to laboratories that meet stringent ... demonstrate scientifically rigorous processes. "Genos is ... in laboratory practices. We,re honored to be receiving ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... 29, 2017 Research and Markets has ... and Global Markets" report to their offering. ... The study ... sequencing, biochips, RNA interference, synthetic biology tools and genome editing ... These technologies and products are analyzed to determine ...
(Date:3/28/2017)... ... 2017 , ... NetDimensions announced today that Scandinavian Health Limited ... management for consistent implementation of standards and regulatory requirements across SHL companies worldwide. ... improve and streamline their training and employee development programs, which are critical to ...
(Date:3/28/2017)... ... March 28, 2017 , ... Benchworks announced that ... Philadelphia. The event was offered by the Chamber of Commerce for Greater Philadelphia ... groups and interaction with speakers who are leaders in their industries. Topics included ...
(Date:3/28/2017)... March 28, 2017 Summary This ... Enzo Biochem and its partnering interests and activities since 2010. ... provides an in-depth insight into the partnering activity of one ... demand company reports are prepared upon purchase to ensure inclusion ... The report will be delivered in PDF format ...
Breaking Biology Technology: