Navigation Links
Statins may stave off septic lung damage says new research study
Date:5/2/2011

Statins may be best known for their ability to reduce cholesterol, but a research report appearing in the May 2011 issue of the Journal of Leukocyte Biology (http://www.jleukbio.org) shows that these same drugs could also play a crucial role in the reduction of lung damage resulting from severe abdominal sepsis and infection.

"We hope that this study will not only provide new knowledge about the complicated pathophysiology behind abdominal sepsis, but also form the basis for more effective and specific treatment options for patients with severe infections," said Henrik Thorlacius, M.D., Ph.D., a researcher involved in the workfrom the Department of Surgery at Skane University Hospital at Lund University, Malmo, Sweden.

To make this discovery, the researchers studied mice with a punctured intestinal bowel and treated half with a statin drug, simvastatin, and the others with only water. The animals treated with simvastatin had much less lung injury than those only given water. Additionally, the simvastatin-treated group demonstrated significantly fewer inflammatory cells in the lung, as well as reduced levels of pro-inflammatory substances. These findings suggest that treatment with statins may be of clinical value for patients with severe abdominal infections.

"Sepsis is a serious medical problem for which few good treatments exist," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology, "This research is very exciting because statins are readily available and have a well established safety profile, making them a prime candidate for efficacy testing."

According to the National Institute of General Medical Sciences, NIH, Sepsis is a major challenge in the intensive care unit, where it is one of the leading causes of death. It is caused when immune chemicals released into the blood to combat infection trigger widespread inflammation, resulting in impaired blood flow, which damages the body's organs by depriving them of nutrients and oxygen. In the worst cases, the heart weakens and multiple organslungs, kidneys, livermay quickly fail and the patient can die. Each year, severe sepsis strikes about 750,000 Americans, and as many as half die, which is more than the number of U.S. deaths from prostate cancer, breast cancer and AIDS combined.


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Study suggests statins may prevent diabetic-related blindness
2. Free statins with fast food could neutralize heart risk, scientists say
3. Statins may treat blood vessel disorder that can lead to fatal strokes
4. Statins may prevent miscarriages
5. Jekyll and Hyde: Cells executioner can also stave off death
6. Lifestyle changes may stave off diabetes for a decade
7. Drinking milk in the morning may help stave off lunchtime hunger
8. Blood-clotting protein linked to cancer and septicemia
9. Septic shock: Nitric oxide beneficial after all
10. CEL-SCI Corporation to Launch Aseptic Filling for Stem Cell Produced Therapies and Other Biological Products
11. RIT researchers help map tsunami and earthquake damage in Japan
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/30/2016)... , Nov. 30, 2016 Not many of us realize that we ... of recovery so we need to do it well. Inadequate sleep levels have been ... blood pressure, stroke, diabetes, and even cancer. Maybe now is the best ... that could help them to manage their sleep quality? ... ...
(Date:11/29/2016)... BOSTON , Nov. 29, 2016 BioDirection, ... rapid point-of-care products for the objective detection of concussion ... the company has successfully completed a meeting with the ... company,s Tbit™ blood test Pre-Submission Package. During the meeting ... Tbit™ system as a precursor to commencement of a ...
(Date:11/29/2016)... CANNES, France , November 29, 2016 Nearly ... Continue Reading ... ... System is part of an efficient Identity Management. (PRNewsFoto/DERMALOG Identification Systems) ... DERMALOG is Germany's largest Multi-Biometric ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... 2016 Oxford Gene Technology ... NGS panel range with the launch of the SureSeq myPanel™ ... of variants in familial hypercholesterolemia (FH). The panel delivers single ... a single small panel and allows customisation by ,mix and ... exons for LDLR , P C ...
(Date:12/8/2016)... Worcester, Mass (PRWEB) , ... December 08, 2016 ... ... KbioBox genetic data bioInformatics portal. In response to client demand KbioBox developed a ... gene edit biodesign program. Both are accessible from KBioBox’s new website, https://www.kbiobox.com/ ...
(Date:12/8/2016)... Francisco, CA (PRWEB) , ... December 08, 2016 ... ... Oculus as finalists in the World Technology Awards. uBiome is one of just ... received across all categories. , In addition to uBiome, companies nominated as finalists ...
(Date:12/8/2016)... , Dec. 8, 2016  Soligenix, Inc. (OTCQB: ... company focused on developing and commercializing products to ... medical need, announced today the long-term follow-up data ... (dusquetide), a first-in-class Innate Defense Regulator (IDR), in ... and neck cancer patients undergoing chemoradiation therapy (CRT).  ...
Breaking Biology Technology: