Navigation Links
Statins may prevent miscarriages
Date:10/10/2008

Hospital for Special Surgery researchers have found that statins may be able to prevent miscarriages in women who are suffering from pregnancy complications caused by antiphospholipid syndrome (APS), according to a study in mice. In this autoimmune syndrome, the body produces antibodies directed at phospholipids, the main components of cell membranes. This news comes from a study published in the October issue of the Journal of Clinical Investigation that is currently online in advance of print.

In low risk pregnancies, APS is associated with a nine-fold increase in miscarriage. In high-risk pregnancies (women who have had at least three prior losses), APS is associated with a 90 percent risk of miscarriage.

"Statins may work as a treatment for women with APS-induced pregnancy complications," said Guillermina Girardi, Ph.D., associate scientist at Hospital for Special Surgery in New York, who is lead author of the study. "They are drugs that have been shown to be very safe. There are a lot of women who continue to take statins through pregnancy and the drugs have not been shown to produce birth defects." Statins do not increase the risk of bleeding like anticoagulants, the current treatment for patients with APS.

In previous studies, Dr. Girardi and colleagues showed that antiphospholipid (aPL) antibodies in female mice caused inflammation that injured the placentas and induced abortions. These antibodies activate a protein, C5a, that activates another protein, tissue factor, that is expressed on the surface of certain white blood cells called neutrophils. This spurs the neutrophils into action, they attack the placenta, and the fetus dies. While investigators had unveiled this basic chain of events, they didn't know any further details about the mechanism.

To find out, Dr. Girardi and colleagues examined the white blood cells from mice that had APS and discovered that these cells expressed certain receptors called PAR2 (
'/>"/>

Contact: Phyllis Fisher
fisherp@hss.edu
212-606-1197
Hospital for Special Surgery
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Controlling for size may also prevent cancer
2. Avocados may help prevent oral cancer, OSU study shows
3. Dietary calcium could possibly prevent the spread of breast cancer to bone
4. Bilberry extract -- can it help prevent certain cancers?
5. Preventing tuberculosis reactivation
6. Knocking out cell receptor may help block fat deposits in tissues, prevent weight gain
7. Scripps research team blocks bacterial communication system to prevent deadly staph infections
8. Frontiers in Cancer Prevention Research
9. NASA technology helps predict and prevent future pandemic outbreaks
10. Childrens Hospital studying drug with the potential to prevent/delay onset of type 1 diabetes
11. Tamiflu effective for treatment and prevention of influenza in children 1 year and older
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2015)... , June 23, 2015   Valencell, ... announced the results of a recent study that ... on the wrist during activity. In a study ... was compared along with the Apple Watch against ... measuring heart rate during activity. The study demonstrated ...
(Date:6/17/2015)... GERMANTOWN, Maryland , June 17, 2015 ...   Produktlinie mit DNA-Tests verbessert den Analyseprozess und ... QGEN ; Frankfurt Prime Standard: QIA) hat heute in ... Produktlinie Investigator ® für ... Die neuen Kits zur Erstellung genetischer Fingerabdrücke bieten eine ...
(Date:6/16/2015)... June 16, 2015 /CNW Telbec/ - handyem Inc. ... around the incorporation of handyem,s HPC-150 portable flow ... the Mo-POD™. This unprecedented model of mobile laboratory ... at the Pennsylvania Convention ... 15 th to 18 th 2015. ...
Breaking Biology News(10 mins):Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 3QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 3QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 4QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 5QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 6handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 2handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 3
... CLEAR Program is Back and Oberthur Technologies Remains a Key Partner -- CHANTILLY, Virginia, November 18, 2010 ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... var shortURL = ""; BitlyCB.alertResponse = function(data) { var s = ,; var first_result; // Results are keyed ...
... SEATTLE, Wash. November 18, 2010 The Paul ... advance important neuroscience and cellular engineering research. The Allen ... and laboratories in Washington, California, Massachusetts and New York. ... paid over three years. "A year ...
... teaching space and Earth sciences, there,s a world of information ... K-12 teachers to bring it into the classroom. The ... grant to professors Paul Ruscher and Alejandro Gallard for a ... a series of courses to be offered to undergraduate and ...
Cached Biology News:The CLEAR Program is Back and Oberthur Technologies Remains a Key Partner 2The CLEAR Program is Back and Oberthur Technologies Remains a Key Partner 3The CLEAR Program is Back and Oberthur Technologies Remains a Key Partner 4The CLEAR Program is Back and Oberthur Technologies Remains a Key Partner 5The CLEAR Program is Back and Oberthur Technologies Remains a Key Partner 6The CLEAR Program is Back and Oberthur Technologies Remains a Key Partner 7The CLEAR Program is Back and Oberthur Technologies Remains a Key Partner 8The CLEAR Program is Back and Oberthur Technologies Remains a Key Partner 9First Allen Distinguished Investigators named 2First Allen Distinguished Investigators named 3FSU researchers helping K-12 teachers bring science down to Earth 2
(Date:6/30/2015)... ... 30, 2015 , ... Matrix Marketing Group, LLC , a leading provider ... to head up its account management department as vice president of client services. ... senior account management and delivery expertise to the growing Matrix Marketing Group team in ...
(Date:6/30/2015)... 30, 2015  Custom Computer Specialists, Inc. ("Custom"), a ... are silver sponsors of the Primary Care Development Corporation,s ... is lending their support of PCDC,s mission to expand ... Since its founding in 1993, PCDC has been a ...  PCDC has financed over 100 completed primary care projects, ...
(Date:6/30/2015)... Dr. Samadi Prostate Cancer Center in New York ... new genetic testing methods for men with an elevated PSA ... Dr. Samadi,s Prostate Cancer Center is ... and optimizing the diagnosis of prostate cancer, both pre-biopsy and ... these revolutionary genetic tests to men with an elevated PSA ...
(Date:6/30/2015)... ... 30, 2015 , ... Smarter Alloys today announced a final ... that allows orthodontists to simultaneously apply different forces to different teeth. The additional ... thrilled about taking SmartArch one step closer to commercial availability for orthodontists and ...
Breaking Biology Technology:Matrix Marketing Group Expands Client Services Team 2Custom Computer Specialists Announces Sponsorship Of The Primary Care Development Corporation's Corporate Circle 2New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 2New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 3New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 4New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 5New case studies for SmartArch orthodontic archwire paves way to product launch later this year 2
... Wednesday, October,22, 2008, Wyeth (NYSE: WYE ) will ... will hold a one-hour conference call with,research analysts at ... and others may listen to the call live or ... be accessed by visiting our website,at http://www.wyeth.com ...
... Coleman to Lead Scientific Operations, NAPLES, Fla., ... ETHANOL(TM), the most advanced third generation biofuels,technology, today ... as Chief,Science Officer. Dr. Coleman, currently the Vice-Principal ... has over 20 years of,experience in the fields ...
... MEETING, Pa., Sept. 8 /Xinhua-PRNewswire-FirstCall/ -- BMP,Sunstone Corporation (Nasdaq: ... Company will present at the following conference:, ... the Grand Hyatt Hotel in Beijing on ... present at 10:20 AM local time. ...
Cached Biology Technology:Algenol Biofuels Appoints Chief Science Officer 2BMP Sunstone Announces Participation in September Investor Conference 2
Curcumin is an extract of turmeric root with antioxidant, anti-tumor promoter, and anti-inflammatory properties. Curcumin inhibits the induction of NOS in macrophages....
UGT1A6 (D-20)...
... is the smallest electronic pressure controller available ... Parker configured this unit specifically for the ... Used in carrier gas flow control, microfluidic ... and hydro-dynamic focusing, the OEM-EPC offers external ...
... Thrust Slide is designed for heavy duty ... limited and substantial side-loading is present. Standard ... millions of trouble-free cycles even in high ... or recirculating ball bearings , Optional corrosion ...
Biology Products: