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Statin warning for pregnant women
Date:12/9/2008

t dissolves in fat.

As expected, the fat-soluble statin, cerivastatin, affected the placenta resulting in reduced growth but the researchers also found that pravastatin the water-soluble statin thought to be potentially compatible for use in pregnancy had the same detrimental effect.

"These results clearly show that the effect of statins on the placenta is not dependent on their lipophilicity as had previously been suggested," said Dr Westwood, whose findings are published in the Journal of Cellular and Molecular Medicine.

"While hydrophilic statins have not been reported to increase the incidence of fetal malformations, our research suggests that they will have a detrimental effect on placental growth, which is likely to result in poor pregnancy outcome.

"Healthcare professionals should continue to advise women to avoid the use of any type of statin once they plan to start a family or when a pregnancy is suspected or confirmed."


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Contact: Aeron Haworth
aeron.haworth@manchester.ac.uk
44-161-275-8383
University of Manchester
Source:Eurekalert

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