Navigation Links
Statin warning for pregnant women
Date:12/9/2008

Pregnant women or those hoping to start or extend a family should avoid using the cholesterol-lowering drugs statins, say scientists.

Current clinical guidelines already recommend that women who are pregnant should stop taking statins but the advice is based on the knowledge that cholesterol is essential for normal fetal development.

Indeed, a 2007 study examining the risk of congenital anomalies in children of pregnant women using statins suggested that the detrimental effects of the drugs may be restricted to fat-soluble or 'lipophilic' statins only.

But new research from The University of Manchester has shown that even water-soluble or 'hydrophilic' statins, such as pravastatin, can affect placental development leading to worse pregnancy outcomes.

"The rapid rise in obesity and type-2 diabetes is a major health issue and affected individuals are often treated with statins to lower circulating cholesterol levels and reduce the risk of heart disease," said Dr Melissa Westwood, a Senior Lecturer in Endocrinology based at the Maternal and Fetal Health Research Centre at St Mary's Hospital, Manchester.

"Given the evolving demographic profile of these conditions, such drugs are increasingly prescribed to women of reproductive age but the actions of statins are not limited to the regulation of cholesterol levels, as they can affect the production of other chemicals in the body too.

"Our study examined the effects that both lipophilic and hydrophilic statins had on a key biological system that is crucial for maintaining the normal function of the placenta, which acts as the nutrient-waste exchange barrier between mother and fetus."

The research, funded by the Biotechnology and Biological Sciences Research Council (BBSRC), used a placental-tissue model that could be maintained in a viable state outside the body for several days and tested the effects of two different statins one water-soluble and one that dissolves in fat.

As expected, the fat-soluble statin, cerivastatin, affected the placenta resulting in reduced growth but the researchers also found that pravastatin the water-soluble statin thought to be potentially compatible for use in pregnancy had the same detrimental effect.

"These results clearly show that the effect of statins on the placenta is not dependent on their lipophilicity as had previously been suggested," said Dr Westwood, whose findings are published in the Journal of Cellular and Molecular Medicine.

"While hydrophilic statins have not been reported to increase the incidence of fetal malformations, our research suggests that they will have a detrimental effect on placental growth, which is likely to result in poor pregnancy outcome.

"Healthcare professionals should continue to advise women to avoid the use of any type of statin once they plan to start a family or when a pregnancy is suspected or confirmed."


'/>"/>

Contact: Aeron Haworth
aeron.haworth@manchester.ac.uk
44-161-275-8383
University of Manchester
Source:Eurekalert

Related biology news :

1. Statins may prevent miscarriages
2. Midge-hunting scientists tackle spread of devastating bluetongue virus
3. Statin does not appear helpful for children with learning disabilities caused by genetic disorder
4. Natural compound in broccoli could treat devastating genetic skin disorder
5. Methylmercury warning
6. Global Viral Forecasting Initiative receives $11M to implement pandemic early warning system
7. Fructose sets table for weight gain without warning
8. Stevens strengthens Dominican Republics Early Warning System for Inundations
9. A home early warning system for cardiac patients
10. Insect warning colors aid cancer and tropical disease drug discovery
11. USGS to help Chile develop volcano early warning system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/21/2016)... 21, 2016 NuData Security announced today that ... of principal product architect and that Jon ... customer development. Both will report directly to ... moves reflect NuData,s strategic growth in its product ... customer demand and customer focus values. ...
(Date:6/15/2016)... ALBANY, New York , June 15, 2016 ... published a new market report titled "Gesture Recognition Market ... Trends and Forecast, 2016 - 2024". According to the ... at USD 11.60 billion in 2015 and is ... and reach USD 48.56 billion by 2024.  ...
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. ... a business relationship that includes integrating Syngrafii,s patented ... branch project. This collaboration will result in greater ... the credit union, while maintaining existing document workflow ... http://photos.prnewswire.com/prnh/20160606/375871LOGO ...
Breaking Biology News(10 mins):
(Date:11/30/2016)... Nov. 30, 2016  GenomOncology today announced the appointment of ... Medical Affairs.  Dr. Coleman will oversee clinical ... proprietary knowledge-enabled platform. The GenomOncology software suite empowers molecular pathologists ... data and clinical decision support, from quality control through reporting. ... , , ...
(Date:11/30/2016)... SEATTLE , Nov. 30, 2016  The ... Allen Cell Collection: the first publicly available collection ... stem cells that target key cellular structures with ... Medical Research, these powerful tools are a crucial ... cells to better understand what makes human cells ...
(Date:11/30/2016)... , 30. November 2016   ... hat heute die Unterzeichnung einer Reihe von ... zufolge wird Evotec AG Screeningleistungen für Mercks ... bereitstellen. Der Zugriff auf diese Bibliotheken in ... eröffnet einen schnelleren Weg zur Ermittlung und ...
(Date:11/30/2016)... ... November 30, 2016 , ... Energetiq Technology, ... introduces the 5th generation, ultra-bright, Laser-Driven Light Source, the EQ-77, at the MRS ... technology, the EQ-77 offers higher radiance and irradiance from a truly broadband white ...
Breaking Biology Technology: