Navigation Links
Statin therapy ineffective in breast cancer prevention
Date:2/4/2009

PHILADELPHIA Laboratory work in animals showed limited activity when statins were given to prevent breast cancer, according to a report in the February issue of Cancer Prevention Research, a journal of the American Association for Cancer Research.

Statins, sold under brand names like Lipitor and Zocor, are primarily given to lower cholesterol and prevent heart disease, and prominent cardiologists almost universally agree that their use has changed the landscape.

The use of these drugs in cancer prevention has been more controversial. Results of epidemiology studies, which rely on looking backward rather than forward and thus are subject to confounding factors, have yielded mixed results when examining breast cancer.

Scientists under the auspices of the NCI, including Ronald Lubet, Ph.D., an NCI program director, and Clinton Grubbs, Ph.D., director of the Chemoprevention Center at the University of Alabama at Birmingham conducted laboratory work in animals to determine if statins actually prevent both ER-positive and ER-negative breast cancer.

In the current study, scientists tested atorvastatin and lovastatin. "We saw no real efficacy from either statin," said Lubet. "Prior studies have shown some but limited efficacy in breast cancer models when these drugs were given through a method that would be the equivalent of intravenously in humans. However, that is not the way people take statins."

Atorvastatin was administered at either 125 or 500 mg/kg in the diet of rats, and it did not alter the incidence of estrogen receptor-positive mammary cancers or its multiplicity. Similarly, no effect of atorvastatin was observed in an estrogen receptor-negative model in mice.

By contrast, when these mice were given 0.4 mg of tamoxifen or 80 mg of bexarotene there was a significant reduction in the multiplicity of mammary tumors. Combining these regimens with atorvastatin did not augment the positive effects of these other agents.

Lovastatin was given at 100 and 500 mg/kg, and it showed no significant preventive -effect similar to atorvastatin.

Lubet said the research into statin use and cancer prevention would continue. "There is always the question of whether there will be a subset of breast cancer where this class of agents will be effective, but the answer at this point is that the present preclinical studies do not support the use of statins as general breast cancer preventive agents" said Lubet.


'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related biology news :

1. Natural compound in broccoli could treat devastating genetic skin disorder
2. Statin does not appear helpful for children with learning disabilities caused by genetic disorder
3. Midge-hunting scientists tackle spread of devastating bluetongue virus
4. Statins may prevent miscarriages
5. Statin warning for pregnant women
6. New drug holds out promise of normal diet for sufferers of devastating PKU genetic disease
7. Statins may treat blood vessel disorder that can lead to fatal strokes
8. A new radiation therapy treatment developed for head and neck cancer patients
9. St. Jude finds factors that accelerate resistance to targeted therapy in lymphoblastic leukemia
10. UC health news: molecular pathway may predict chemotherapy effectiveness
11. MIT works toward safer gene therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... With the biometrics market to exceed ... technologies that innovative and agile startups must incorporate ... the changing competitive landscape: multifactor authentication (MFA), point-of-sale ... "Companies can no longer afford to cut ... Dimitrios Pavlakis , Industry Analyst at ABI Research. ...
(Date:2/21/2017)... Ore. , Feb. 22, 2017  IBM (NYSE: ... (Avamere Health Services, Infinity Rehab, Signature Hospice, Home Health, ... will apply the power of IBM cognitive computing to ... centers. By analyzing data streaming from sensors in senior ... and environmental conditions, and obtain deeper learnings into the ...
(Date:2/21/2017)... 21, 2017 Der weltweite Biobanking-Sektor ... Nach einem Gespräch mit mehr als 50 Vertretern aus verschiedenen ... überwinden gilt, um diese Prognose zu realisieren. ... Zu ... der finanziellen Mittel für die Biobank, die Implementierung Zeit ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... 22, 2017 Scientists propose in Nature ... damage in Gaucher and maybe other lysosomal storage diseases ... costs than current therapies. An international research ... , which also included investigators from the University of ... data Feb. 22. The study was conducted in mouse ...
(Date:2/22/2017)... Dublin - Research and Markets has announced ... Type, By Application, By End User, By Region, By Country: Opportunities ... ... is forecasted to grow at a CAGR of 11.33% during 2016-2021. ... protection market is driven by the surging demand for less toxic ...
(Date:2/22/2017)... DIEGO , Feb. 22, 2017  Creative ... expansion of its translational research program using its ... of laboratory facilities in San Diego.  The Company ... BioLabs facility, a biotechnology incubator sponsored by the ... In November 2016, the Company obtained an ...
(Date:2/21/2017)... , ... February 21, 2017 , ... ... VTX-1 Liquid Biopsy System , a fully automated benchtop system for collecting intact ... VTX-1 is being launched at the Molecular Medicine Tri Conference (Tri-Con) Annual Meeting ...
Breaking Biology Technology: