Navigation Links
Statin therapy ineffective in breast cancer prevention
Date:2/4/2009

PHILADELPHIA Laboratory work in animals showed limited activity when statins were given to prevent breast cancer, according to a report in the February issue of Cancer Prevention Research, a journal of the American Association for Cancer Research.

Statins, sold under brand names like Lipitor and Zocor, are primarily given to lower cholesterol and prevent heart disease, and prominent cardiologists almost universally agree that their use has changed the landscape.

The use of these drugs in cancer prevention has been more controversial. Results of epidemiology studies, which rely on looking backward rather than forward and thus are subject to confounding factors, have yielded mixed results when examining breast cancer.

Scientists under the auspices of the NCI, including Ronald Lubet, Ph.D., an NCI program director, and Clinton Grubbs, Ph.D., director of the Chemoprevention Center at the University of Alabama at Birmingham conducted laboratory work in animals to determine if statins actually prevent both ER-positive and ER-negative breast cancer.

In the current study, scientists tested atorvastatin and lovastatin. "We saw no real efficacy from either statin," said Lubet. "Prior studies have shown some but limited efficacy in breast cancer models when these drugs were given through a method that would be the equivalent of intravenously in humans. However, that is not the way people take statins."

Atorvastatin was administered at either 125 or 500 mg/kg in the diet of rats, and it did not alter the incidence of estrogen receptor-positive mammary cancers or its multiplicity. Similarly, no effect of atorvastatin was observed in an estrogen receptor-negative model in mice.

By contrast, when these mice were given 0.4 mg of tamoxifen or 80 mg of bexarotene there was a significant reduction in the multiplicity of mammary tumors. Combining these regimens with atorvastatin did not augment the positive effects of these other agents.

Lovastatin was given at 100 and 500 mg/kg, and it showed no significant preventive -effect similar to atorvastatin.

Lubet said the research into statin use and cancer prevention would continue. "There is always the question of whether there will be a subset of breast cancer where this class of agents will be effective, but the answer at this point is that the present preclinical studies do not support the use of statins as general breast cancer preventive agents" said Lubet.


'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related biology news :

1. Natural compound in broccoli could treat devastating genetic skin disorder
2. Statin does not appear helpful for children with learning disabilities caused by genetic disorder
3. Midge-hunting scientists tackle spread of devastating bluetongue virus
4. Statins may prevent miscarriages
5. Statin warning for pregnant women
6. New drug holds out promise of normal diet for sufferers of devastating PKU genetic disease
7. Statins may treat blood vessel disorder that can lead to fatal strokes
8. A new radiation therapy treatment developed for head and neck cancer patients
9. St. Jude finds factors that accelerate resistance to targeted therapy in lymphoblastic leukemia
10. UC health news: molecular pathway may predict chemotherapy effectiveness
11. MIT works toward safer gene therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2016)... March 29, 2016 LegacyXChange, Inc. ... "LEGX" and SelectaDNA/CSI Protect are pleased to announce our ... in a variety of writing instruments, ensuring athletes signatures ... created collectibles from athletes on LegacyXChange will be assured ... the DNA. Bill Bollander , CEO ...
(Date:3/18/2016)... , March 18, 2016 ... Suppliers of Biometrics, ICT, Manned & Unmanned Vehicles, Physical infrastructure ... & security companies in the border security market and the ... and Europe has led visiongain ... companies improved success. --> defence & security ...
(Date:3/14/2016)... Allemagne, March 14, 2016 ... - --> - Renvoi : image disponible ... --> --> DERMALOG, ... fournit de nouveaux lecteurs d,empreintes digitales pour l,enregistrement ... DERMALOG sera utilisé pour produire des cartes d,identité ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... ... May 25, 2016 , ... Lajollacooks4u has become a ... consistently been rated one of its top attractions. Fortune 500 companies, such as ... in a unique and intimate team-building experience. , Each event kicks off with an ...
(Date:5/25/2016)... AZ (PRWEB) , ... May 25, 2016 , ... ... Dr. Michael Fitzmaurice recently became double board-certified in surgery and surgery of the ... 2015. Dr. Fitzmaurice is no stranger to going above and beyond in his ...
(Date:5/25/2016)... ... May 25, 2016 , ... WEDI, the nation’s leading authority on the use ... W. Stellar has been named by the WEDI Board of Directors as WEDI’s president ... executive leader with more than 35 years of experience in healthcare, association management and ...
(Date:5/24/2016)... ... May 24, 2016 , ... Cell therapies for ... be accelerated by research at Worcester Polytechnic Institute (WPI) that yielded a newly ... tissue regeneration. , The novel method, developed by WPI faculty members Raymond Page, ...
Breaking Biology Technology: