Navigation Links
Statin does not appear helpful for children with learning disabilities caused by genetic disorder
Date:7/15/2008

Use of simvastatin by children with neurofibromatosis type 1 (NF1), a genetic disorder that can cause learning disabilities, did not result in improved cognitive function, according to a study in the July 16 issue of JAMA.

Characteristics of NF1 (incidence 1:3,000) include skin disorders, problems with small and large movement skills as well as the frequent occurrence of cognitive disabilities, such as visual-spatial skills, nonverbal long-term memory and attention span, according to background information in the article. Some NF1 studies involving mice suggested that use of a statin could improve cognitive deficits.

Lianne C. Krab, M.Sc., of Erasmus MC University Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands, and colleagues conducted a randomized trial to study the effect of the statin simvastatin on cognitive function of 62 children with NF1. The participants received simvastatin or placebo treatment once daily for 12 weeks.

After the treatment period, there was no significant difference between the simvastatin and placebo groups on several cognitive measures (determined by testing), including assessing nonverbal long-term memory, assessing attention and prism adaptation task (measurement of adaptation of the angle of hand movements in response to prism glass distortion, which is thought to be dependent on cerebellar function).

In the secondary outcome measures, the researchers found a significant improvement in the simvastatin group in object assembly scores, which was specifically observed in children with poor baseline performance. Other secondary outcome measures, such as attention fluctuations and a developmental test of visual-motor integration revealed no significant effect of simvastatin treatment.

"The negative outcome of this trial suggests that simvastatin should not be prescribed to ameliorate the cognitive deficits associated with NF1. Further studies to evaluate a long
'/>"/>

Contact: Ype Elgersma, Ph.D.
y.elgersma@erasmusmc.nl
JAMA and Archives Journals
Source:Eurekalert

Page: 1 2

Related biology news :

1. Natural compound in broccoli could treat devastating genetic skin disorder
2. Tigers disappear from Himalayan refuge
3. Californias wildflowers are disappearing, new book by UCR ecologist cautions
4. Mars water appears to have been too salty to support life
5. A Great Lakes mystery: The case of the disappearing species
6. Exposure to low levels of radon appears to reduce the risk of lung cancer, new study finds
7. A compound extracted from olives inhibits cancer cells growth and prevents their appearance
8. Wild chimpanzees appear not to regularly experience menopause
9. Humans appear hardwired to learn by over-imitation
10. Laser can spot illness before symptoms appear
11. Scientists identify embryonic stem cells by appearance alone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... previous studies have shown that marine noise can affect ... from the Universities of Bristol and Exeter and the ... have demonstrated that boat noise stops embryonic development and ... (specifically the sea slug Stylocheilus striatus used ... swim away and later feed on toxic alga but ...
(Date:7/30/2014)... Red Queen in Lewis Carroll,s Through the Looking ... National University of Singapore improved a 35-year-old ecology ... decades to millions of years. , The new ... incorporates the "Red Queen Effect," an evolutionary hypothesis ... which suggests that organisms must constantly increase their ...
(Date:7/30/2014)... knows the shortest distance between two points is a ... sperm have been taking the familiar axiom to heart. ... thought to be intense, with each racing for the ... some species, sperm form cooperative groups that allow them ... , A new study, conducted by Heidi Fisher, a ...
Breaking Biology News(10 mins):Boat noise impacts development and survival of sea hares 2Classic Lewis Carroll character inspires new ecological model 2Classic Lewis Carroll character inspires new ecological model 3When cooperation counts 2When cooperation counts 3
... Inc., Case Western Reserve University and the Cleveland FES ... a five-year, $4.4 million contract from the National Center ... National Institute of Child Health and Human Development (NICHD). ... $2.3 million of the total award over the five-year ...
... established a foothold in understanding how p53 protects against ... aging and lifespan are not well studied. In work ... flies show new evidence that despite the protective role ... levels of p53 activity--at least in some cell types--may ...
... industry could have a damaging effect on plant life, ... New Jersey Institute of Technology (NJIT). , The ... shows that nanoparticles of alumina (aluminum oxide) slowed the ... corn, cucumber, cabbage, carrot and soybean. Alumina nanoparticles are ...
Cached Biology News:Cyberkinetics, Case to develop system to help restore extremity function 2Cyberkinetics, Case to develop system to help restore extremity function 3Cyberkinetics, Case to develop system to help restore extremity function 4Cyberkinetics, Case to develop system to help restore extremity function 5Cyberkinetics, Case to develop system to help restore extremity function 6New clues to the dark side of a key anti-tumor guardian 2NJIT study shows nanoparticles could damage plant life 2
(Date:7/31/2014)... North Shore Towers, a luxury co-op community ... Energy, one of the nation’s leading combined heating and power ... its 43-year-old CHP system. The original CHP system had been ... extend the life of the plant, GI Energy was contracted ... heat recovery equipment, while maintaining continuous operation of the entire ...
(Date:7/31/2014)... SAN DIEGO, July 31, 2014 ... a leading company using proprietary taste science technologies ... for the food, beverage, and ingredient supply industries, ... 2014.  The Company ended the second quarter with ... "During the past quarter Senomyx ...
(Date:7/31/2014)... Diego, CA (PRWEB) July 31, 2014 ... announced today the integration of Omicsoft’s Array Suite with ... both platforms will be able to send data in ... integration works with all versions of tranSMART including the ... the art statistics, visualization and storage for the analysis ...
(Date:7/31/2014)... , July 31, 2014   BioLife Solutions , ... manufacturer and marketer of proprietary clinical grade hypothermic ... precision thermal shipping products for cells and ... 2014 financial results will be released on Thursday, August ... conference call and live webcast at 4:30 p.m. ET ...
Breaking Biology Technology:North Shore Towers Partners with GI Energy to Install Turnkey Natural Gas-Fired Combined Heat and Power Plant 2SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 2SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 3SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 4SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 5SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 6SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 7SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 8SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 9SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 10SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 11SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 12SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 13SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 14SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 15SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 16Rancho BioSciences, in Partnership with Omicsoft, have Integrated Array Suite with tranSMART 2Rancho BioSciences, in Partnership with Omicsoft, have Integrated Array Suite with tranSMART 3BioLife Solutions to Report Financial Results for Second Quarter 2014 and Provide Business Update on August 7, 2014 2
... scientists are harnessing nanotechnology to quickly produce ultra-lightweight, ... everyday paper. Simply coating a sheet of ... silver nanowires makes a highly conductive storage device, ... and engineering. "Society really needs a low-cost, ...
... , , MONTREAL, Dec. 7 ... wholly-owned U.S. affiliate, has been selected by the U.S. Department ... the construction and operation of its waste-to-biofuels facility to be ... only four that have been selected in the larger demonstration ...
... , PRINCETON, N.J., Dec. 7 PharmaNet ... services to pharmaceutical, biotechnology, generic drug and medical device ... Company as Chief Information Officer. , In his ... corporate information technology function including strategy development and execution ...
Cached Biology Technology:Dip ordinary paper into ink infused with nanotubes and nanowires to create an instant battery 2Enerkem Awarded $50 Million Funding by U.S. Department of Energy for its Mississippi Biorefinery Project 2Enerkem Awarded $50 Million Funding by U.S. Department of Energy for its Mississippi Biorefinery Project 3Stephen Kasay Joins PharmaNet Development Group as Chief Information Officer 2
Buffer used for mitocapture assays....
... Kit, 25 purifications. Allows rapid ... efficient removal of unincorporated CyDye label ... superior yields of labeled cDNA probe. ... cDNA labeled by either direct incorporation ...
Propidium Iodide: {3,8-diamino-5-[3-(diethylmethylammonio)propyl]-6-phenylphenanthridinium diodide}. Antifade Solution: p-Phenylenediamine and glycerol in PBS solution. 2.5ug/mL Propidium Iodide (PI)...
Detects activated caspases in living cells. Simple/sensitive/straight-forward procedure takes only 30 minutes. Results can be analyzed by flow cytometry/fluorescence microscopy/fluorescence plate rea...
Biology Products: