Navigation Links
Starving prostate cancer
Date:11/2/2011

Each year about 3300 Australian men die of prostate cancer. It's Australia's second worst cancer killer for men, matching the impact of breast cancer on women.

Current therapies for prostate cancer include surgical removal of the prostate, radiation, freezing the tumour or cutting off the supply of the hormone testosteronebut there are often side-effects including incontinence and impotence.

Growing cells need an essential nutrient, the amino acid called leucine, which is pumped into the cell by specialised proteins. And this could be prostate cancer's weak link.

Dr Jeff Holst and his team at the Centenary Institute found, in a study to be published this month in Cancer Research, that prostate cancer cells have more pumps than normal.

This allows the cancer cells to take in more leucine and outgrow normal cells.

"This information allows us to target the pumps and we've tried two routes. We found that we could disrupt the uptake of leucine firstly by reducing the amount of the protein pumps, and secondly by introducing a drug that competes with leucine. Both approaches slowed cancer growth, in essence 'starving' the cancer cells," Jeff says.

First author Dr Qian Wang says by targeting different sets of pumps, the researchers were able to slow tumour growth in both the early and late stages of prostate cancer.

"In some of the experiments, we were able to slow tumour growth by as much as 50 per cent. Our hope is that we could develop a treatment that slows the growth of the cancer so that it would not require surgical removal. If animal trials are successful over the next few years then clinical trials could start in as little as five years," he says.

Jeff says one of the other spin-offs of the discovery is a better understanding of the links between prostate cancer and eating foods high in leucine.

"Diets high in red meat and dairy are correlated with prostate cancer
'/>"/>

Contact: Suzie Graham
s.graham@centenary.org.au
61-418-683-166
Centenary Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Starving fat suppresses appetite
2. Researchers discover that same gene has opposite effects in prostate, breast cancers
3. UCLA researchers develop system that finds prostate cancer spread earlier than conventional imaging
4. Genomatix, USU and HJF execute a CRADA: Prostate cancer prognostic marker discovery by NGS
5. Cancer biomarker -- detectable by blood test -- could improve prostate cancer detection
6. USC research determines apparent genetic link to prostate cancer in African-American men
7. Mushroom compound suppresses prostate tumors
8. Microbubble-delivered combination therapy eradicates prostate cancer in vivo
9. High percentage of omega-3s in the blood may boost risk of aggressive prostate cancer
10. Jan-Åke Gustafsson leads team with $5.2M for prostate cancer research
11. No scalpel: Minimally invasive breakthrough for men’s enlarged prostates improves symptoms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... University School of Medicine announced today that it ... funded by the Bill & Melinda Gates Foundation. ... Gynecology and Reproductive Sciences; and Vice Chair of ... of Medicine will pursue an innovative global health ... to Assess Fetal Neurodevelopment.", Grand Challenges Explorations (GCE) ...
(Date:11/4/2014)... published research study examining only marketing directed at ... food restaurants has found that the majority of ... to such marketing tactics. , Authored by Arizona ... the study is the first to examine the ... exterior of fast food restaurants and its relationship ...
(Date:11/4/2014)... majority of Madagascar,s 101 species of lemurs are threatened ... the rainforests they call home. A new study by ... have on rainforest tree populations, which raises concerns about ... region,s rich biodiversity. , A large proportion of trees ... Lemurs in turn disperse the seeds of their fruit ...
Breaking Biology News(10 mins):Temple University School of Medicine receives Grand Challenges Explorations grant 2Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3Gardeners of Madagascar rainforest at risk 2Gardeners of Madagascar rainforest at risk 3
... many centuries, sustained major fisheries on both sides of ... largely collapsed. A new paper in the open-access, peer-reviewed ... University of Iceland and Marine Research Institute in Reykjavik ... fisheries, due to fisheries-induced evolution. Cod fishing is ...
... Prevention Research (SPR) will hold its annual meeting, May ... Avenue, NW, Washington, D.C., 20001. The featured story ... reach authors by registering (free) for the meeting to ... schedule media interviews anytime during the meeting. , ...
... to increase in Hawaii,s mountains, deadly non-native bird ... invading most of the last disease-free refuges for ... birds. A just-published U.S. Geological Survey ... "disease invasion" by examining the present altitudinal range ...
Cached Biology News:Did the North Atlantic fisheries collapse due to fisheries-induced evolution? 2Society for Prevention Research Meeting in Washington, D.C., May 27-29, 2009 2Society for Prevention Research Meeting in Washington, D.C., May 27-29, 2009 3Jeepers creepers: Climate change threatens endangered honeycreepers 2Jeepers creepers: Climate change threatens endangered honeycreepers 3
(Date:11/26/2014)... 26, 2014 The North America ... the market for detailed analysis of the growth ... to reach $616.3 million by 2018, growing at ... , Browse through the TOC of the North ... an idea of the in-depth analysis and industry ...
(Date:11/26/2014)... PHILADELPHIA , Nov. 26, 2014 Space ... Human exploration of space requires astronauts to maintain consistently ... and success, and prevent potential errors and accidents. Despite ... is known about how cognition is affected by prolonged ... Now, Penn Medicine researchers are poised to ...
(Date:11/26/2014)... The ETC (Emerging Technology Centers) http://www.etcbaltimore.com , ... that applications for AccelerateBaltimore™ (AB) 2015 program will ... a big idea?,” asked ETC’s President Deb Tillett. ... AccelerateBaltimore helps you and your big idea go ... Interested game changers with “big ideas” should ...
(Date:11/26/2014)... SonaCare Medical, a leading manufacturer of ... participated in the American Urology Association’s (AUA) surgical ... opinion leaders in urology presented on the latest ... masses while attendees had the opportunity to evaluate ... labs. Attendees at the Los Angeles, CA lab, ...
Breaking Biology Technology:The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 2The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 3Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 2Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 3Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 4AccelerateBaltimore Applications to Close in 6 Days 2AccelerateBaltimore Applications to Close in 6 Days 3SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 3
... OMAHA, Neb., March 14 Creighton University,law, science, ... taste,of what it takes to convert scientific research ... selected through a competitive application and,interview process -- ... for the,first time on Feb. 13. A three-year, ...
... March 14 Wyeth (NYSE: WYE ),announced today ... Annual,Global Healthcare Conference on Wednesday, March 19, 2008 at ... M. Mahady, Senior Vice,President, Wyeth and President, Wyeth Pharmaceuticals., ... at, http://www.wyeth.com and available for replay following the ...
... March 14 Diamyd Medical AB,( http://www.omxgroup.com, ticker: ... given Diamyd Medical permission to start a Phase III,clinical ... with the therapeutic,diabetes vaccine Diamyd(R)., (Logo: http://www.newscom.com/cgi-bin/prnh/20080314/297194 ... study and to be able to offer this,promising drug ...
Cached Biology Technology:NSF Funds New Entrepreneurship Program 2Wyeth to Present at the Lehman Brothers Eleventh Annual Global Healthcare Conference 2Diamyd Gets Authorization to Begin Phase III Study in the US 2