CINCINNATIPeptides that target blood vessels in fat and cause them to go into programmed cell death (termed apoptosis) could become a model for future weight-loss therapies, say University of Cincinnati (UC) researchers.
A research team led by Randy Seeley, PhD, of UC's Metabolic Diseases Institute, has found that obese animal models treated with proapoptotic peptide experienced decreased food intake and significant fat loss.
The study was published online ahead of print Jan. 26, 2010, in Diabetes, the official journal of the American Diabetes Association.
White adipose (fat) tissue is vascularized, much like a tumor, and growth of fat tissue is highly dependent on the tissue's ability to build new blood vesselsa phenomenon called angiogenesis.
Inhibiting adipose angiogenesisessentially "starving" fat tissuecan reverse the effects of a high-fat diet in mice and rats, says Seeley.
"The body is extremely efficient at controlling energy balance," says Seeley, a professor in UC's internal medicine department and recipient of the 2009 Outstanding Scientific Achievement Award from the American Diabetes Association.
"Think of fat tissue like a bathtub," he says. "To keep the amount of water the same, you have to make sure that the speed of the water coming in and the water going out match. If the water is coming in faster than the water is going out, eventually you have to build a bigger bathtub.
"Obesity is the same. People who eat more calories than they burn have to build a bigger fat tissue 'bathtub,' and building new blood vessels is crucial to building this bigger bathtub. For each additional pound of fat tissue, you need to build a mile of blood vessels.
"What we found is that if we can target these fat tissue blood vessels, animals eat less and lose weight as their 'bathtubs' get smaller."
Seeley and his team treated lean and obese mice and rats with the proapoptotic
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University of Cincinnati Academic Health Center