Navigation Links
Staphylococcus aureus bacteria turns immune system against itself
Date:11/19/2013

white blood cells were healthy in this environment and could clear bacteria. But the addition of a chemical to stimulate NET formation triggered macrophage death. Realizing that a toxic product was being generated by S. aureus in response to NETs, the team used high performance liquid chromatography and mass spectrometry techniques to isolate the molecule.

They discovered that S. aureus were converting NETs into 2'-deoxyadenosine (dAdo), a molecule which is toxic to macrophages. This effectively turned NETs into a weapon against the immune system.

"Sooner or later almost every human gets some form of S. aureus infection. Our work describes for the first time the mechanism that these bacteria use to exclude macrophages from infected sites," Schneewind said. "Coupled with previously known mechanisms that suppress the adaptive immune response, the success of these organisms is almost guaranteed."

S. aureus bacteria are found on the skin or in the respiratory tracts of colonized humans and commonly cause skin infections in the form of abscesses or boils. Normally not dangerous, severe issues arise when the bacteria enter the bloodstream, where they can cause diseases such as sepsis and meningitis. Antibiotic-resistant strains, such as methicillin-resistant S. aureus (MRSA), are difficult to treat and have plagued healthcare systems around the world.

Schneewind and his team hope to leverage their findings toward therapies against S. aureus infections. But both genes and the dAdo molecule are closely related to important human physiological mechanisms, and Schneewind believes targeting these in bacteria, without harming human function, could be difficult.

"In theory you could build inhibitors of these bacterial enzymes or remove them," Schneewind said. "But these are untested waters and the pursuit of such goal requires a lot more study."


'/>"/>

Contact: Kevin Jiang
kevin.jiang@uchospitals.edu
773-795-5227
University of Chicago Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Bacteria use lethal cytotoxins to evade antibiotic treatment
2. No peak in sight for evolving bacteria
3. Structure of bacterial nanowire protein hints at secrets of conduction
4. Evidence of 3.5 billion-year-old bacterial ecosystems found in Australia
5. Bacteria may allow animals to send quick, voluminous messages
6. Study shows moms may pass effects of stress to offspring via vaginal bacteria and placenta
7. Changing the conversation -- polymers disrupt bacterial communication
8. How zinc starves lethal bacteria to stop infection
9. Battle against resistant bacteria takes huge leap forward
10. Study links intestinal bacteria to rheumatoid arthritis
11. Biochemists find incomplete protein digestion is a useful thing for some bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/10/2015)... Fingerprint Cards (FPC) has received an ... the distributor World Peace Industrial Group (WPI), part of WPG ... Asia . Deliveries are planned to take place during ... manufacturers in China . The order value ... of + 1 000 MSEK for 2015.   Jörgen ...
(Date:4/27/2015)... , April 27, 2015  For more than ... trade show has been the premier worldwide event for ... 2015 is a must-attend event for any local, national, ... into the emerging commercial markets and current applications of ... innovations of this projected $48 billion industry, and how ...
(Date:4/20/2015)... The announcement comes as demand ... Management (GRM), Ireland,s foremost records management ... built up an impressive track record of clients within the ... the records management sector in Dubai . ... staffbase and employ a further eight staff members at its ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 235 Million 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3
... from mismatched nucleotide base pairs in the DNA double helix ... errors provide the basis for adaption to environmental stress. As ... small protein called MutS for "Mutator S" controls ... from microbes to humans. Understanding the repair process holds importance ...
... available in German . ... a highly concentrated protein solution that imparts the eye its high ... must remain clear and transparent. To this end ocular lens cells ... machinery present in all other cells of the human body for ...
... led by scientists at the University of Miami (UM) Rosenstiel ... circulation from the Mississippi River plume played a substantial role ... 2010 Deepwater Horizon incident. These findings provide new information on ... of Mexico. The research, published in the Oct. 2013 issue ...
Cached Biology News:Berkeley Lab researchers get a detailed look at a DNA repair protein in action 2Berkeley Lab researchers get a detailed look at a DNA repair protein in action 3A protein safeguards against cataracts 2A protein safeguards against cataracts 3New research illustrates Mississippi River's role 2
(Date:5/29/2015)... , May 29, 2015  Caris Life Sciences® ... studies in which researchers utilized Caris Molecular Intelligence®, ... identify potential therapeutic targets in patients with colorectal ... the programmed cell death protein 1 (PD-1) and ... 1 at the 2015 American Society of Clinical ...
(Date:5/29/2015)... May 28, 2015 Research and Markets ... Jain PharmaBiotech,s new report "Cytogenetics - Technologies, ... This report deals with cytogenetics in a ... to describe the chromosome structure and identify abnormalities ... biology, it is also referred to as molecular ...
(Date:5/29/2015)... 29, 2015 Results from a Phase ... and its ability to reduce the size of melanoma ... published in the Journal of Clinical Oncology. , ... IIIB, IIIC and IV melanoma, a potentially fatal form ... was to evaluate the safety and efficacy of the ...
(Date:5/29/2015)... Worth, Texas (PRWEB) May 29, 2015 Translation ... grow. This is for a good reason--if used in a ... wonders for the offering of a business product or service ... which translation can have a positive effect on a company's ... or service that anyone in the world can use, why ...
Breaking Biology Technology:Multi-Platform Molecular Profiling from Caris Life Sciences Identifies Clinically Actionable Targets for Novel Immunotherapy Drugs 2Multi-Platform Molecular Profiling from Caris Life Sciences Identifies Clinically Actionable Targets for Novel Immunotherapy Drugs 3Multi-Platform Molecular Profiling from Caris Life Sciences Identifies Clinically Actionable Targets for Novel Immunotherapy Drugs 4Global Cytogenetics Market Report 2015-2024 - Technologies, Markets and Companies 2Global Cytogenetics Market Report 2015-2024 - Technologies, Markets and Companies 3Study Published in Journal of Clinical Oncology Reports Talimogene Laherparepvec Improvesdurable Responses in Patients with Advanced Melanoma 2Three Ways Translation Can Help Businesses Grow 2
... July 27, 2011 Cadence Pharmaceuticals, Inc. (NASDAQ: ... commercializing proprietary products principally for use in the hospital setting, ... June 30, 2011 financial results on Wednesday, August 3, 2011. ... and live webcast to discuss the financial results on Wednesday, ...
... 27, 2011 Keryx Biopharmaceuticals, Inc. (Nasdaq: ... its Phase 3 registration trial of KRX-0401 (perifosine) for ... 3 trial, with over 430 randomized patients, is being ... the Food and Drug Administration (FDA) and with Fast-Track ...
... CEM Corporation , a leading global provider ... with its microwave peptide synthesis products . In ... the prior year in its automated peptide synthesizer instrument ... record number of systems. Additionally, CEM,s products were well ...
Cached Biology Technology:Keryx Biopharmaceuticals Announces Completion of Patient Enrollment in KRX-0401 (Perifosine) Phase 3 Refractory Advanced Colorectal Cancer Study 2Keryx Biopharmaceuticals Announces Completion of Patient Enrollment in KRX-0401 (Perifosine) Phase 3 Refractory Advanced Colorectal Cancer Study 3Keryx Biopharmaceuticals Announces Completion of Patient Enrollment in KRX-0401 (Perifosine) Phase 3 Refractory Advanced Colorectal Cancer Study 4Keryx Biopharmaceuticals Announces Completion of Patient Enrollment in KRX-0401 (Perifosine) Phase 3 Refractory Advanced Colorectal Cancer Study 5Record Year for CEM's Peptide Synthesis Business 2Record Year for CEM's Peptide Synthesis Business 3
... Fiberboard boxes are ideal for use in refrigerators, freezers, ... racks. Four vibrant colors allow for color coding to ... liquid nitrogen drainage or promote cool air circulation. Supplied ... holds 100 tubes. Box dimensions: 13 x ...
RABBIT ANTI BACTERIAL HISTIDASE...
REGULATED IN DEVELOPMENT AND DNA DAMAGE RESPONSES 1,HIF-1 responsive RTP801...
Homo sapiens HCLS1 associated protein X-1 Antigen: Recombinant Protein...
Biology Products: