Navigation Links
Staph stoppers
Date:12/20/2013

University of Iowa researchers have developed a new vaccine that protects against lethal pneumonia caused by Staphylococcus aureus (staph) bacteria, including drug-resistant strains like MRSA.

The research team was led by Patrick Schlievert, professor and chair of microbiology in the UI Carver College of Medicine. The findings are published this week in the Journal of Infectious Disease.

The new vaccine targets toxins that are made and secreted by staph bacteria. Earlier work by Schlievert's team found these toxins are responsible for the serious, sometimes deadly, symptoms produced by staph infections, including high fever, low blood pressure, and toxic shock. The researchers believed a vaccine that blocked the action of these toxins might prevent the serious illness caused by the bacteria.

Using an animal model that closely resembles human staph infection, the researchers showed that vaccination against three staph toxins provided almost complete protection against staph infections. The vaccinated animals were protected from disease even when they were infected with very high doses of bacteria. Furthermore, not only did the vaccine protect the animals from dying, but seven days after vaccination there were no disease-causing bacteria remaining in the animals' lungs.

"Our study suggests that vaccination against these toxins may provide protection against all strains of staph," Schlievert says. "If we can translate this finding into an effective vaccine for people it could potentially prevent millions of cases of serious and milder skin and soft tissue infections yearly."

The team also found that passive immunizationusing serum from vaccinated animals to immunize other animalswas successful. This finding suggests that antibodies induced by the vaccination are the protective factor.

According to the Centers for Disease Control and Prevention, Staphylococcus aureus bacteria are the most significant cause of serious infections and infection-related deaths in the Unites States. These bacteria cause many kinds of infections, from boils and other skin infections to life-threatening pneumonias and sepsis. Approximately 70,000 Americans develop staphylococcal pneumonia every year, including cases caused by highly antibiotic resistant MRSA strains. Many of these patients die from their illness, and many require extensive convalescence.

Previous attempts to develop vaccines have targeted proteins on the surface of staph bacteria, but these vaccines have not been successful. In the current study, Schlievert and his colleagues found that vaccination against bacterial cell-surface proteins actually increased the severity of the infection. In contrast, the new vaccine, which targets staph toxins, provided almost complete protection against staph infections.


'/>"/>

Contact: Richard Lewis
richard-c-lewis@uiowa.edu
319-384-0012
University of Iowa
Source:Eurekalert

Related biology news :

1. Staphylococcus aureus bacteria turns immune system against itself
2. University of Wisconsin chemists find new compounds to curb staph infection
3. New compound overcomes drug-resistant Staph infection in mice
4. A drug used to treat HIV might defuse deadly staph infections
5. Sanctuary chimps show high rates of drug-resistant staph
6. Selenium suppresses staph on implant material
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2016)... DALLAS , June 20, 2016 ... criminal justice technology solutions for public safety, investigation, ... by the prisons involved, it has secured the ... Corrections (DOC) facilities for Managed Access Systems (MAS) ... (4) additional facilities to be installed by October, ...
(Date:6/9/2016)... June 9, 2016  Perkotek an innovation leader in attendance control systems is proud ... work hours, for employers to make sure the right employees are actually signing in, ... ... ... ...
(Date:6/3/2016)... Das DOTM (Department ... hat ein 44 Millionen $-Projekt ... einschließlich Personalisierung, Registrierung und IT-Infrastruktur, an Decatur ... Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte internationale Anbieter ... aber Decatur wurde als konformste und innovativste ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... 2, 2016 CytRx Corporation (NASDAQ: ... in oncology, today announced the appointment of Earl ... consultant, and private healthcare investor, to its Board of ... with clinical and strategic experience at the highest level," ... CEO. "As one of the world,s leading orthopedic surgeons, ...
(Date:12/2/2016)... ... December 01, 2016 , ... Aerocom Healthcare ( ... hospitals, will present its chain-of-custody solution for tracking and securing medications at booth ... Dec. 4-8, 2016. , Aerocom has a proven solution for tracking medications via ...
(Date:12/2/2016)... ... December 01, 2016 , ... ... Nanowear on their recent FDA Class II 510(k) clearance for their flagship medical ... in commercializing remote cardiac monitoring devices that rely on cloth-based nanosensors. While other ...
(Date:12/2/2016)... The immunohistochemistry (IHC) market is projected ... of 7.3% during the forecast period of 2016 to 2021 dominated ... accounted for the largest share of immunohistochemistry (IHC) market, by end ... , , ... market spread across 225 pages, profiling 10 companies and supported with ...
Breaking Biology Technology: