Navigation Links
Stanford scientists turn adult skin cells into muscle and vice versa
Date:4/30/2009

In a study featured on the cover of the May issue of The FASEB Journal, researchers describe how they are able to reprogram human adult skin cells into other cell types in order to decipher the elusive mechanisms underlying reprogramming. To demonstrate their point, they transformed human skin cells into mouse muscle cells and vice versa. This research shows that by understanding the regulation of cell specialization it may be possible to convert one cell type into another, eventually bypassing stem cells.

"Regenerative medicine provides hope of novel and powerful treatments for many diseases, but depends on the availability of cells with specific characteristics to replace those that are lost or dysfunctional," said Helen M. Blau, Ph.D., the senior scientist involved in the study, Associate Editor of The FASEB Journal, Member of the Stem Cell Institute, and Director of the Baxter Laboratory in Genetic Pharmacology at Stanford. "We show here that mature cells can be directly reprogrammed to generate those necessary cells, providing another way besides embryonic stem cells or induced pluripotent stem cells of overcoming this important bottleneck to restoring tissue function."

The Stanford scientists sought to transform one specialized adult cell from one species into a different specialized adult cell of another species. To do this, they first used a chemical treatment to fuse skin and muscle cells together, producing cells that had nuclei from human skin cells and mouse muscle cells. By being encapsulated within the same cell wall, the human skin cells and mouse muscle nuclei could now "talk" to one another via chemical signals. Then, the scientists looked at the genes expressed from the human skin nuclei and mouse muscle nuclei. (This was possible because one cell type was human and the other was mouse, so the genes could be distinguished based on species differences.) After several experiments, they were able to induce the hu
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Stanford scientists find new solutions for the arsenic-poisoning crisis in Asia
2. Stanford researchers develop biodegradable substitutes for wood, plastic bottles and other materials
3. From stem cells to new organs: Stanford and NYU scientists cross threshold in regenerative medicine
4. Biofuels boom could fuel rainforest destruction, Stanford researcher warns
5. Stanford launches $100 million initiative to tackle energy issues
6. New World post-pandemic reforestation helped start Little Ice Age, say Stanford scientists
7. Powerful online tool for protein analysis provided pro bono by Stanford geneticist
8. Cell movements totally modular, Stanford study shows
9. Key link in how plants adapt to climate discovered by Stanford researchers
10. Stanford researchers: Global warming is killing frogs and salamanders in Yellowstone Park
11. Circadian clock may be critical for remembering what you learn, Stanford researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/14/2014)... LA JOLLA, CA – October 14, 2014 – Scientists ... $6.6 million from the National Institutes of Health (NIH) ... most prevalent virus-induced hemorrhagic fever disease in Africa. The ... disease and why some patients die, while others survive ... researchers to understand the basic mechanism of how Lassa ...
(Date:10/14/2014)... team of researchers, led by the Chinese Academy of ... Nature Genetics a brief genomic history of tomato ... tomato plant. , The C.M. Rick Tomato Genetics Resource ... this study by providing seed of both cultivated tomato ... builds on the first tomato genome sequence completed just ...
(Date:10/14/2014)... October 14, 2014 – Over the past decades, we ... institutions to meet the needs of infants for social ... these infants to thrive. , Infancy and ... of the cortex. A generation of research suggests that ... cortical development and cognitive function. In contrast, deprivation and ...
Breaking Biology News(10 mins):Scripps Research Institute team receives $6.6 million to investigate deadly Lassa virus 2Institutional rearing may increase risk attention-deficit disorder 2
... less be as simple as leaving serving dishes on the stove ... from Cornell University, it can. At this week,s ... director of the Cornell Food and Brand Lab, shared findings of ... "We looked at whether serving foods from the kitchen counter, instead ...
... and CAMBRIDGE (April 26, 2010) Pericytes, the contractile ... angiogenesis, the "sprouting" of new blood vessels, according to ... the Massachusetts Institute of Technology (MIT). The study, published ... among the first to examine mechanical signaling by pericytes ...
... A new study links progression of a lethal type ... immune system genes, suggesting how complex the immune response is ... immune system proteins for treatment. Previous research found ... with this type of brain cancer, called glioblastoma multiforme. However, ...
Cached Biology News:Cellular mechanical forces may initiate angiogenesis 2Brain tumor growth linked to lowered expression of hundreds of immune function genes 2Brain tumor growth linked to lowered expression of hundreds of immune function genes 3
(Date:10/19/2014)... The Asia-Pacific Bromine Market report defines ... analysis and forecast of revenue. , Browse through ... report, to get an idea of the in-depth ... the segmentation in the Asia-Pacific bromine market, and ... , http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , Bromine is a ...
(Date:10/19/2014)... The report "Chocolate, Cocoa Beans, Lecithin, ... Geography Trend and Forecast (2011 - 2016)," analyzes ... and studies the major market drivers, restraints, and opportunities ... Asia. , The global chocolate market is expected to ... 2016 at an estimated CAGR of 2.7% from 2011 ...
(Date:10/19/2014)... 2014 According to market research ... WLAN Controllers; Wireless gateways)]- Global Advancements, Forecasts and ... global Outdoor Wi-Fi market with analysis and forecasting ... also identifies the drivers and the restrains for ... opportunities and challenges. , Browse 65 market data ...
(Date:10/18/2014)... 2014 The report "1,6-Hexanediol Market ... Forecasts to 2019", analyzes the global market on ... understand the industry details such as the key ... geographic regions. , Browse 81 Market Data Tables ... in-depth TOC on “1,6-Hexanediol Market by Application and ...
Breaking Biology Technology:The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 2Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 3Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 21,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 31,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 5
... chooses AMICAS to drive improvements in customer ... service and operational efficiency, ... leader in radiology and medical image and information management,solutions, today ... California,s most influential radiology groups., (Logo: http://www.newscom.com/cgi-bin/prnh/20060202/AMICASLOGO ...
... July 28 Ranbaxy,Pharmaceuticals Inc. (RPI), a ... Gurgaon, India announced today that under an,agreement ... authorized,generic of Omeprazole 40 mg Capsules in ... indicated for the treatment of acid-related disease,including ...
... Pa., July 25 BioTrends Research Group, Inc.,released ... offering comprehensive insight into the management of,renal anemia ... Disease,(CKD) and Dialysis. The report provides information from ... online survey fielded in,June 2008., In the ...
Cached Biology Technology:Arcadia Radiology Medical Group Chooses AMICAS 2Arcadia Radiology Medical Group Chooses AMICAS 3Ranbaxy Launches Omeprazole 40 mg Capsules 2BioTrends Releases Quarterly TreatmentTrends(TM): Nephrology Report Highlighting Market Trends for Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism 2BioTrends Releases Quarterly TreatmentTrends(TM): Nephrology Report Highlighting Market Trends for Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism 3
... 23 years of experience in the development ... antibodies to large and small peptides, proteins, ... plasmid DNA-encoded antigens. We understand and appreciate ... hybridoma development programs are never "cookbook". We ...
... The Rapid-Screen cDNA Library Panels were ... just three sets of PCRs to identify ... analysis is performed in a 96-well "Master ... from 5,000 clones. Having identified the positive ...
... The Rapid-Screen cDNA Library Panels were ... just three sets of PCRs to identify ... analysis is performed in a 96-well "Master ... from 5,000 clones. Having identified the positive ...
... The ProteoSpin CBED Maxi Kit provides ... volumes of dilute protein solutions for buffer exchange, ... protein samples. The kit is based on spin-column ... ion exchanger. Salts such as MgCl 2 , ...
Biology Products: