Navigation Links
Stanford scientists turn adult skin cells into muscle and vice versa
Date:4/30/2009

In a study featured on the cover of the May issue of The FASEB Journal, researchers describe how they are able to reprogram human adult skin cells into other cell types in order to decipher the elusive mechanisms underlying reprogramming. To demonstrate their point, they transformed human skin cells into mouse muscle cells and vice versa. This research shows that by understanding the regulation of cell specialization it may be possible to convert one cell type into another, eventually bypassing stem cells.

"Regenerative medicine provides hope of novel and powerful treatments for many diseases, but depends on the availability of cells with specific characteristics to replace those that are lost or dysfunctional," said Helen M. Blau, Ph.D., the senior scientist involved in the study, Associate Editor of The FASEB Journal, Member of the Stem Cell Institute, and Director of the Baxter Laboratory in Genetic Pharmacology at Stanford. "We show here that mature cells can be directly reprogrammed to generate those necessary cells, providing another way besides embryonic stem cells or induced pluripotent stem cells of overcoming this important bottleneck to restoring tissue function."

The Stanford scientists sought to transform one specialized adult cell from one species into a different specialized adult cell of another species. To do this, they first used a chemical treatment to fuse skin and muscle cells together, producing cells that had nuclei from human skin cells and mouse muscle cells. By being encapsulated within the same cell wall, the human skin cells and mouse muscle nuclei could now "talk" to one another via chemical signals. Then, the scientists looked at the genes expressed from the human skin nuclei and mouse muscle nuclei. (This was possible because one cell type was human and the other was mouse, so the genes could be distinguished based on species differences.) After several experiments, they were able to induce the human skin nuclei to produce mouse muscle genes and induce the muscle nuclei to produce human skin geneseffectively transforming the cell from one type to the other.

"Reprogramming mature cells will likely complement the use of embryonic stem cells in regenerating tissues," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "By elucidating the regulators of reprogramming, as the Stanford group is doing, it may be possible to generate replacement cells in cases where stem cells are not present or not appropriate."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Stanford scientists find new solutions for the arsenic-poisoning crisis in Asia
2. Stanford researchers develop biodegradable substitutes for wood, plastic bottles and other materials
3. From stem cells to new organs: Stanford and NYU scientists cross threshold in regenerative medicine
4. Biofuels boom could fuel rainforest destruction, Stanford researcher warns
5. Stanford launches $100 million initiative to tackle energy issues
6. New World post-pandemic reforestation helped start Little Ice Age, say Stanford scientists
7. Powerful online tool for protein analysis provided pro bono by Stanford geneticist
8. Cell movements totally modular, Stanford study shows
9. Key link in how plants adapt to climate discovered by Stanford researchers
10. Stanford researchers: Global warming is killing frogs and salamanders in Yellowstone Park
11. Circadian clock may be critical for remembering what you learn, Stanford researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... ISTANBUL , June 9, 2016  Perkotek an innovation leader in attendance control ... to seamlessly log work hours, for employers to make sure the right employees are ... Logo - http://photos.prnewswire.com/prnh/20160609/377486LOGO ... ... ...
(Date:6/2/2016)... June 2, 2016 The Department of ... awarded the 44 million US Dollar project, for the ... Plates including Personalization, Enrolment, and IT Infrastructure , ... the production and implementation of Identity Management Solutions. Numerous renowned ... Decatur was selected for the most ...
(Date:5/24/2016)... patient care by providing unparalleled technology to leaders of the medical imaging industry.  As ... added to the range of products distributed by Ampronix. Photo - ... ... ... ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... June 27, 2016   Ginkgo Bioworks , a ... engineering, was today awarded as one of the ... the world,s most innovative companies. Ginkgo Bioworks is ... the real world in the nutrition, health and ... directly with customers including Fortune 500 companies to ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle ... people with peritoneal or pleural mesothelioma. Their findings are the subject of a new ... , Diagnostic biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma ...
(Date:6/23/2016)... - FACIT has announced the creation of a ... Propellon Therapeutics Inc. ("Propellon" or "the Company"), to ... of first-in-class WDR5 inhibitors for the treatment of ... an exciting class of therapies, possessing the potential ... patients. Substantial advances have been achieved with the ...
(Date:6/23/2016)... -- The Prostate Cancer Foundation (PCF) is pleased to announce 24 new ... prostate cancer. Members of the Class of 2016 were selected from a pool ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
Breaking Biology Technology: