Navigation Links
Stanford bioengineers close to brewing opioid painkillers without using opium from poppies
Date:8/24/2014

called opiates. The other two important opiates are codeine, which has been used as a cough remedy, and thebaine, which is further refined by chemical processes to create higher-value therapeutics such as oxycodone and hydrocodone, better known by brand names such as OxyContin and Vicodin, respectively.

Today legal poppy farming is restricted to a few countries--including Australia, France, Hungary, India, Spain and Turkey--supervised by the International Narcotics Control Board, which seeks to prevent opiates like morphine, for instance, from being refined into illegal heroin.

The biggest market for legal opiates, and their opioid derivatives, is the United States, where pharmaceutical factories use chemical processes to create the refined products that are used as pain-killing pills. However poppies are not grown in significant quantities in the U.S., creating various international dependencies and vulnerabilities in the supply of these important medicines.

Subtitle: Turning Yeast Into a Pharmaceutical Factory

The thrust of Smolke's work for a decade has been to pack the entire production chain, from the fields of poppies, through all the subsequent steps of chemical refining, into yeast cells using the tools of bioengineering.

What Smolke's team has now done is to carefully reprogram the yeast genomethe master instruction set that tells every organism how to liveto behave like a poppy when it comes to making opiates.

The process involved more than simply adding new genes into yeast. Opioid molecules are complex three-dimensional objects. In nature they are made in specific regions inside the poppy. Since yeast cells do not have these complex structures and tissues, the Stanford team had to recreate the equivalent of poppy-like "chemical neighborhoods" inside their bioengineered yeast cells.

It takes about 17 separate chemical steps to make the opioid compounds used in pills. Some of these step
'/>"/>

Contact: Tom Abate
tabate@stanford.edu
650-736-2245
Stanford School of Engineering
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Stanford scientists develop a water splitter that runs on an ordinary AAA battery
2. Stanford professor finds that wildfires and other burns play bigger role in climate change
3. Stanford study shows how to power California with wind, water and sun
4. Stanford biologist warns of early stages of Earths 6th mass extinction event
5. Oil palm plantations threaten water quality, Stanford scientists say
6. Stanfords Precourt Institute partners with KQED on a new e-book series on energy
7. Net energy analysis should become a standard policy tool, Stanford scientists say
8. Stanford research shows importance of European farmers adapting to climate change
9. Stanford researchers rethink natural habitat for wildlife
10. Stanford biologists help solve fungal mysteries
11. Behind the scenes of the IPCC report, with Stanford scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stanford bioengineers close to brewing opioid painkillers without using opium from poppies
(Date:11/12/2014)... 2014 Crossmatch™, a leading provider of biometric ... fingerprint readers have been deployed throughout Montparnasse Pasteleria, ... Mexico . The bakery chain implemented the Crossmatch ... caused by employees clocking in for each other. ... Montparnasse relied on paper timecards and a mechanical time ...
(Date:11/7/2014)... BURBANK, Calif. , Nov. 7, 2014  In conjunction ... Burbank Police Departments, The Community Foundation of the ... BURBANK DNA JUSTICE PROJECT," a $250,000 initiative to ... successful initial phase. In its first six months of existence, ... desperately needed evidence support for local law enforcement. ...
(Date:11/6/2014)... PITTSBURGH--Speed is an asset for a predator. Except when that ... The tiger beetle, relative to its size, is the fastest ... 120 body lengths per second (at about five miles per ... To take the sprinting gold from the tiger beetle, a ... BUT! The tiger beetle has a problem. At peak speeds, ...
Breaking Biology News(10 mins):Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2The tiger beetle: Too fast to see 2
... Researchers at the University of Illinois at Chicago College ... on the nervous system to create the devastation of Huntington,s ... Nature Neuroscience online. The researchers were able to ... called JNK3, which is expressed only in neurons and, further, ...
... soil microbe that uses chemical warfare to fight off ... of its arsenal, researchers report, making use of an ... known to do: break a non-activated carbon-carbon bond in ... in the journal Nature , provides the first ...
... play a role in growth of some types of ... cancer development, say researchers from the Lombardi Comprehensive Cancer ... findings, presented at the annual meeting of the Endocrine ... this protein, known as Stat5a, may be different in ...
Cached Biology News:Huntington's disease deciphered 2Huntington's disease deciphered 3Researchers describe 'implausible' chemistry that produces herbicidal compound 2Dual role in breast tissue for a protein involved in leukemia 2
(Date:11/21/2014)... (PRWEB) November 20, 2014 The November ... available as an open access journal featuring the following ... fluorescent proteins to preserve photoresponsiveness in the retina , ... fluorescent in situ hybridization using chromogenic substrates in zebrafish ... DNA, RNA, and protein electrophoresis , Nuclear ...
(Date:11/21/2014)... November 21, 2014 2014 Deep ... Industry” is a professional and in-depth research report ... ferrocyanide information, like its definition, classification, application, ... overview. This report covers the international market analysis, ... (such as the US, Europe, Asia, China, Japan ...
(Date:11/21/2014)... - Aequus Pharmaceuticals Inc. (the "Company" or "Aequus") ... a brokered private placement offering (the "Brokered Offering") ... Securities Inc. and Clarus Securities Inc. acted as ... syndicate of agents that also included Wolverton Securities ... Concurrently with the Brokered Offering, the Company also ...
(Date:11/18/2014)... Calif. , Nov. 18, 2014 Cord ... platinum sponsor of the 10th Annual World Stem Cell Summit, ... medicine stakeholders. The 2014 World Stem Cell Summit will be ... San Antonio, Texas . The ... and development of lifesaving cures and therapies, convening the most ...
Breaking Biology Technology:BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 2Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 3Aequus Pharmaceuticals closes $4.2 million private placement financing 2Aequus Pharmaceuticals closes $4.2 million private placement financing 3Cord Blood Registry Sponsors 2014 World Stem Cell Summit 2Cord Blood Registry Sponsors 2014 World Stem Cell Summit 3
... the potential to revolutionize the world of sensors: motion, ... micro scale down to the nano requires finding a ... gadgetry. In a paper appearing in ... Zhiping Xu of MIT,s Department of Civil and Environmental ...
... BASF filed a lawsuit in the United States District Court ... Pont de Nemours and Company) for infringement of BASF,s patented ... Specifically, DuPont,s Optimum GAT corn product incorporates BASF,s patented promoter ... toward an herbicide class known as AHAS or ALS inhibitors. ...
... to accelerate basic research and drive personalized medicine. , ... today announced that it has signed an agreement with ... Rosetta Biosoftware, a business unit of Rosetta Inpharmatics LLC, ... The deal allows Microsoft to incorporate genetic, genomic, metabolomic ...
Cached Biology Technology:Biomimetic-engineering design can replace spaghetti tangle of nanotubes in novel material 2BASF Sues DuPont for Patent Infringement 2Microsoft Signs Agreement With Merck & Co. Inc. to Acquire Assets of Rosetta Biosoftware, Strengthening Position in Life Sciences Industry 2Microsoft Signs Agreement With Merck & Co. Inc. to Acquire Assets of Rosetta Biosoftware, Strengthening Position in Life Sciences Industry 3
... Pulser Xcell microbial system, 100 to ... for electroporation of bacterial and fungal ... unit, PC module for exponential decay ... cuvettes (5 each of 0.1 and ...
... solution. In PBS containing ... other proprietary stabilizers; 0.2 ... to stabilize activity of ... at high conjugate dilutions ...
... Pulser Xcell eukaryotic system, 100 ... is used for electroporation of ... the main unit, CE module ... or square-wave pulses, ShockPod shocking ...
... on Macintosh operating systems to predict ... sequence up to 3,200 bases, which ... and GC clamps for mutation detection ... constant denaturing gel electrophoresis (CDGE), and ...
Biology Products: