Navigation Links
Stanford bioengineers close to brewing opioid painkillers without using opium from poppies
Date:8/24/2014

For centuries poppy plants have been grown to provide opium, the compound from which morphine and other important medicines such as oxycodone are derived.

Now bioengineers at Stanford have hacked the DNA of yeast, reprograming these simple cells to make opioid-based medicines via a sophisticated extension of the basic brewing process that makes beer.

Led by Associate Professor of Bioengineering Christina Smolke, the Stanford team has already spent a decade genetically engineering yeast cells to reproduce the biochemistry of poppies with the ultimate goal of producing opium-based medicines, from start to finish, in fermentation vats.

"We are now very close to replicating the entire opioid production process in a way that eliminates the need to grow poppies, allowing us to reliably manufacture essential medicines while mitigating the potential for diversion to illegal use," said Smolke, who outlines her work in the August 24th edition of Nature Chemical Biology.

In the new report Smolke and her collaborators, Kate Thodey, a post-doctoral scholar in bioengineering, and Stephanie Galanie, a doctoral student in chemistry, detail how they added five genes from two different organisms to yeast cells. Three of these genes came from the poppy itself, and the others from a bacterium that lives on poppy plant stalks.

This multi-species gene mashup was required to turn yeast into cellular factories that replicate two, now-separate processes: how nature produces opium in poppies, and then how pharmacologists use chemical processes to further refine opium derivatives into modern opioid drugs such as hydrocodone.

Subtitle: From Plants to Pills Today

Plant-derived opium has been used and abused for centuries, but a good place to begin the modern story is with the use of morphine during World War II.

Morphine is one of three principal pain killers derived from opium. As a class they are
'/>"/>

Contact: Tom Abate
tabate@stanford.edu
650-736-2245
Stanford School of Engineering
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Stanford scientists develop a water splitter that runs on an ordinary AAA battery
2. Stanford professor finds that wildfires and other burns play bigger role in climate change
3. Stanford study shows how to power California with wind, water and sun
4. Stanford biologist warns of early stages of Earths 6th mass extinction event
5. Oil palm plantations threaten water quality, Stanford scientists say
6. Stanfords Precourt Institute partners with KQED on a new e-book series on energy
7. Net energy analysis should become a standard policy tool, Stanford scientists say
8. Stanford research shows importance of European farmers adapting to climate change
9. Stanford researchers rethink natural habitat for wildlife
10. Stanford biologists help solve fungal mysteries
11. Behind the scenes of the IPCC report, with Stanford scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stanford bioengineers close to brewing opioid painkillers without using opium from poppies
(Date:10/14/2014)... ATHENS, Ohio (Oct. 14, 2014)—It,s been millions of years ... but a team led by Ohio University scientists is ... to model airflow through dinosaur snouts. The research has ... not only breathe but to enhance the sense of ... pretty ,nosy, animals," said Ohio University doctoral student Jason ...
(Date:10/14/2014)... 14, 2014 – High doses of fish oil supplements, rich ... common type of irregular heartbeat in which the heart can ... of the AFFORD trial led by the Montreal Heart Institute ... of Cardiology on October 7th. , For the trial, ... were randomly assigned to 4 grams of fish oil a ...
(Date:10/14/2014)... between 10 and 20 years to develop, providing ... intervention if detected early, which may be possible ... clinical researchers. , Dr Jeremy Humphris and ... Medical Research, analysed medical histories and tumour samples ... patients, operated on between 1994 and 20122. Roughly ...
Breaking Biology News(10 mins):Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3Early detection window when pancreatic cancer is in the family 2
... a long-distance race may do serious harm rather than ... much, according to a cardiologist at UT Southwestern Medical ... too much water during a race could put themselves ... a loss in the body's sodium content that can ...
... announced today the launch of the new GeneChip(R) ... with PreAnalytiX -- a joint venture between QIAGEN ... BD (Becton, Dickinson and Company). The new kits ... use with Affymetrix GeneChip technology and improve gene ...
... Earth history some 251 million years ago was preceded by ... by a delayed recovery that lasted for millions of years. ... a sharp decline in atmospheric oxygen levels was likely a ... very slow recovery. , Earth's land at the time was ...
Cached Biology News:Too much water may be as dangerous as too little during long-distance athletic events 2Affymetrix Launches New Globin-Reduction Kits and Protocol Developed with PreAnalytiX 2Affymetrix Launches New Globin-Reduction Kits and Protocol Developed with PreAnalytiX 3Scientists reveal the shape of a protein that helps retroviruses break into cells 2Scientists reveal the shape of a protein that helps retroviruses break into cells 3
(Date:10/19/2014)... The Asian Automatic patient billing report defines ... forecast of revenue. The Automatic patient billing market in ... by 2018, at a developing CAGR of 7.2% from ... the Asian Automatic patient billing market, to get an ... a glimpse of the segmentation of this market in ...
(Date:10/19/2014)... According to market research report ... Controllers; Wireless gateways)]- Global Advancements, Forecasts and Analysis ... Outdoor Wi-Fi market with analysis and forecasting of ... identifies the drivers and the restrains for this ... and challenges. , Browse 65 market data tables ...
(Date:10/18/2014)... The Asia-Pacific hardware encryption display market report ... analysis and forecast of revenue. This market was valued ... $51,362.6 million by 2018, at a CAGR of 58.4% ... of the Asia-Pacific hardware encryption market report, to get ... provides a glimpse of the segmentation of the market, ...
(Date:10/18/2014)... The report " Cloud Analytics Market [Cloud ... Machine; Video; Predictive Analytics: Global Advancements, Delivery Models, ... (2013 - 2018) ", defines and segments the ... with an in-depth analysis and forecasting of market ... this market, various restraints, and opportunities impacting it ...
Breaking Biology Technology:The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 2Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 3Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 4The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 3Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 2Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 3Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 4Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 5
... ... HPCwire,s Readers, Choice Award for Best Application of Green Computing. The award was ... ongoing in Portland, Ore. , ... Portland, OR (Vocus) Nov. 17, 2009 --- The U.S. Department of Energy,s ...
... Pharma guarantees to purchase 50,000 KINLYTIC vials over next ... Biosystems Inc. (MBX:TSX), a biotech company focused on virology ... agreement with Riso Pharma that guarantees purchases of not ... years. KINLYTIC (Urokinase) is Microbix, thrombolytic agent for treating ...
... , ROCKVILLE, Md., Nov. 17 Neuralstem, Inc. (NYSE Amex: ... the third quarter ended September 30, 2009. , (Logo: ... of 2009, the Company reported a net loss of $5,096,983, or ... $0.10 per share, for the comparable 2008 period. The increase was ...
Cached Biology Technology:Argonne Recognized for "Green Computing" in 2009 HPCwire Readers' and Editors' Choice Awards 2Argonne Recognized for "Green Computing" in 2009 HPCwire Readers' and Editors' Choice Awards 3Argonne Recognized for "Green Computing" in 2009 HPCwire Readers' and Editors' Choice Awards 4Microbix Signs Marketing Agreement For Kinlytic(R)(Urokinase) In Growing Middle East Region 2Microbix Signs Marketing Agreement For Kinlytic(R)(Urokinase) In Growing Middle East Region 3Neuralstem, Inc. Reports Third Quarter Financial Results and Provides Business Update 2Neuralstem, Inc. Reports Third Quarter Financial Results and Provides Business Update 3Neuralstem, Inc. Reports Third Quarter Financial Results and Provides Business Update 4Neuralstem, Inc. Reports Third Quarter Financial Results and Provides Business Update 5Neuralstem, Inc. Reports Third Quarter Financial Results and Provides Business Update 6Neuralstem, Inc. Reports Third Quarter Financial Results and Provides Business Update 7
75 x 25 mm; sterile, recommended for immunohistochemistry of cell lines growing in suspension, Poly-D-Lysine coated, glass slides with polystyrene vessel, lid and safety removal tool...
IMAGEQUANT 400 WKSTN, 1 EA. Category: ImageQuant CCD Imagers....
IMAGEQUANT 400 IQTL, 1 EA. Category: ImageQuant CCD Imagers....
ImageQuant 100 UV, 1 EA. Category: ImageQuant CCD Imagers....
Biology Products: