Navigation Links
Stanford and Google team up to simulate key drug receptor
Date:12/20/2013

Roughly 40 percent of all medications act on cells' G protein-coupled receptors (GPCRs). One of these receptors, beta 2 adrenergic receptor site (B2AR), naturally transforms between two base configurations; knowing the precise location of each of approximately 4,000 atoms is crucial for ensuring a snug fit between it and the drug.

Now, researchers at Stanford and Google have conducted an unprecedented, atom-scale simulation of the receptor site's transformation, a feat that could have significant impact on drug design.

This is the first scientific project to be completed using Google Exacycle's cloud computing platform, which allows scientists to crunch big data on Google's servers during periods of low network demand.

The study was published online in Nature Chemistry on Dec. 15.

As a type of GPCR, the B2AR is a molecule that sits within the membrane of most cells. Various molecules in the body interact with the receptor's exterior, like two hands shaking, to trigger an action inside the cell.

"GPCRs are the gateway between the outside of the cell and the inside," said co-author Vijay Pande, a professor of chemistry and, by courtesy, of structural biology and computer science at Stanford. "They're so important for biology, and they're a natural, existing signaling pathway for drugs to tap into."

Roughly half of all known drugs including pharmaceuticals as well as natural molecules such as caffeine target some GPCR, and many new medications are being designed with these receptor sites in mind. The 2012 Nobel Prize in Chemistry was co-awarded to Brian Kobilka, a professor at the Stanford University School of Medicine, for his role in discovering and understanding GPCRs.

Traditionally, maps that detail each atom of GPCR, and other receptors, are created through a technique called X-ray crystallography. The technique is industry standard, but it can only visualize a molecule in its resting st
'/>"/>

Contact: Bjorn Carey
bccarey@stanford.edu
650-725-1944
Stanford University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Keck award enables Carnegie Mellon and Stanford to dramatically expand crowdsourced RNA design
3. Climate change may create price volatility in the corn market, say Stanford and Purdue researchers
4. Stanford and MIT scientists win Perl-UNC Neuroscience prize
5. Americas clean energy policies need a reality check, say Stanford researchers
6. Support for climate change action drops, Stanford poll finds
7. Stanford scientists document fragile land-sea ecological chain
8. Stanford researchers help predict the oceans of the future with a mini-lab
9. Stanford marine biologist Barbara Block wins Rolex Award for Enterprise
10. Stanford scientists find molecule to starve lung cancer and improve ventilator recovery
11. Stanford researchers calculate global health impacts of the Fukushima nuclear disaster
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... 25, 2015 Research ... of the "Natural Language Processing Market by ... OCR, Pattern & Image Recognition) - Worldwide Forecast ... The key vendors occupying the market are ... Microsoft Corporation, NetBase Solutions, SAS Institute Inc., Verint ...
(Date:7/2/2015)... 25, 2015 Research and ... "Next Generation Biometrics Market by Application, Technology, Function ... to their offering. The next generation biometrics ... at a CAGR of 17.9% between 2015 and 2020 ... for the market. Safran SA ( ...
(Date:7/2/2015)... 2015 Fingerprint Cards has received an ... FPC1155 from the distributor World Peace Industrial Group (WPI), part ... Asia . Deliveries are planned to take ... used by smartphone manufacturers in Asia . ... communicated revenue guidance of approximately 2,200 MSEK for 2015. ...
Breaking Biology News(10 mins):Natural Language Processing Market by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) - Worldwide Forecast to 2020 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 3FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2
... Mice given quercetin, a naturally occurring substance found ... the flu, according to a study published by The ... exercise increased the susceptibility of mice to the flu, ... a close chemical relative of resveratrol, is present in ...
... have discovered that a gene controlling whether blood vessels ... linked to a vascular disorder in the brain that ... mice, and the new findings are the first to ... this particular brain disorder, known as BAVM, and to ...
... Psychiatry, researchers at the Johns Hopkins University School of ... associated with schizophrenia that links three previously known, yet ... until now the many known genetic factors implicated in ... Akira Sawa, M.D., Ph.D., director of the program in ...
Cached Biology News:Substance found in fruits and vegetables reduces likelihood of the flu 2Substance found in fruits and vegetables reduces likelihood of the flu 3Gene is likely cause of stroke-inducing vascular malformations 2Gene is likely cause of stroke-inducing vascular malformations 3Hopkins researchers piece together gene 'network' linked to schizophrenia 2Hopkins researchers piece together gene 'network' linked to schizophrenia 3
(Date:6/30/2015)... June 30, 2015 /PRNewswire/ - Resverlogix Corp. ("Resverlogix") ... shares of Resverlogix have approved the resolutions relating ... Limited of 5,600,000 units at a price of ... unit being comprised of one common share and ... of approximately CAD$15 million; and (ii) the amendment ...
(Date:6/30/2015)... -- Juniper Pharmaceuticals, Inc. (Nasdaq: JNP ), a specialty ... unmet medical needs in women,s health, today announced ... at the Cantor Fitzgerald Inaugural Healthcare Conference as ... PM EDTLocation: , Le Parker Meridien Hotel, New ... under  ,Investor, or  click here The ...
(Date:6/30/2015)... ... June 30, 2015 , ... With its latest ... selectivity to achieve faster flow rates in comparison to nylon or polyethersulfone (PES). ... space to allow easy liquid flow while trapping particulates as small as 0.2 ...
(Date:6/30/2015)... ... 2015 , ... Matrix Marketing Group, LLC , a leading provider of ... head up its account management department as vice president of client services. Amanda ... account management and delivery expertise to the growing Matrix Marketing Group team in Denver, ...
Breaking Biology Technology:Resverlogix Corp. Shareholders Approve Matters Relating to Licensing and Equity Arrangement 2Resverlogix Corp. Shareholders Approve Matters Relating to Licensing and Equity Arrangement 3Juniper Pharmaceuticals to Present at Cantor Fitzgerald Inaugural Healthcare Conference on July 8, 2015 2New Nanofiber Membrane Provides Fast, Efficient Filtration 2Matrix Marketing Group Expands Client Services Team 2
... molecule famous for storing the genetic blueprints for all ... a new paper,* researchers at the National Institute of ... of DNA can be used to purify the highly ... carbon nanotubes are needed to make "quantum wires" for ...
... 2011 HumanTouch, LLC announced that it has ... by the U.S. General Services Administration. 8(a) STARS ... engineered to provide cutting-edge technology solutions from award-winning ... is designed to promote small business utilization when ...
... Inc. (NYSE Amex: CUR ) announced it ... develop its human neural stem cell technology for the ... "Research to Treat Cancerous Brain Tumors with Neural Stem ... Investigator John Zhang, MD, PhD, Professor of Neurosurgery, Loma ...
Cached Biology Technology:Armchair science: DNA strands that select nanotubes are first step to a practical 'quantum wire' 2HumanTouch Awarded 8(a) STARS II GWAC Contract 2Neuralstem Awarded Department of Defense Contract for Brain Cancer Research 2Neuralstem Awarded Department of Defense Contract for Brain Cancer Research 3
... Insulin exerts its ... the insulin receptor, a ... of two Alpha subunits ... arranged in the following ...
Excellent safety and durability., Remote control can be easily operated in your hand., Constant voltage control with 2 sets of terminals., Precise and durable circuit design. ...
... Dye runs faster than Bromophenol blue,or ... gels.,Orange G dye migrates with DNA ... migration at this size,prevents the obscuring ... the front of DNA migration.,The Orange ...
... Description: 100 g ... 70 kDa YAP from Human/mouse/rat samples. ... Research Focus: ... -20C Shipping ...
Biology Products: