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Stanford/Packard researchers find disease genes hidden in discarded data
Date:10/24/2007

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The researchers knew they were on the right track when they pinpointed about 66 percent of nearly 300 previously identified obesity-related genes. In contrast, none of the individual experiments identified more than 30 percent of the same panel, and the average experiment identified only 2 percent.

Further analysis identified 16 genes that were positive in six or more experiments, and three that were positive in eight experiments. Of those three, one was a known obesity gene. The other two have no known ties to obesity, yet. "Now we can take these two candidates straight to the geneticists and the lab to begin figuring out what they do," said Butte.

The comparison approach should be applicable to many other disorders. "The data are out there," said Butte, who has pioneered ways to categorize and index the vast quantities of biomedical information in preparation for further study. "We need to translate it and make it useful for other researchers and disorders."


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Contact: Robert Dicks
rdicks@lpch.org
650-497-8364
Stanford University Medical Center
Source:Eurekalert

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