Navigation Links
Stanford/Packard researchers find disease genes hidden in discarded data

STANFORD, Calif. - Previously hidden obesity-related genes have been uncovered from old experiments by researchers at the Stanford University School of Medicine and Lucile Packard Children's Hospital. The finding suggests that useful information about many medical disorders may be languishing in mountains of discarded data.

"We've devised a fairly simple way to convert large amounts of existing raw data into candidate disease genes for further genetic study," said Atul Butte, MD, PhD, a pediatrician at Packard Children's and director of the hospital's Center for Pediatric Bioinformatics. "When we put the information together, we were not only able to pinpoint those that have already been identified, but we also came up with some very interesting new predictions."

The investigators teased out the existence of more than a dozen new obesity-related genes by comparing the results of 49 independent experiments conducted by other researchers - none of which had yielded similar results on their own.

Butte, who is also an assistant professor of medicine and of pediatrics at the medical school, plans to investigate the biological roles of the new genes soon. The research appears in the Oct. 5 advance access section of the journal Bioinformatics.

Identifying novel genetic culprits for complicated diseases like obesity, diabetes and autism is tricky. Unlike cystic fibrosis, which is caused by a mutation in just one gene, these conditions are often the result of a "perfect storm" of interacting genes and environmental factors. This complexity leaves researchers with limited time to pursue only their most promising results, leaving other candidates behind.

Managing the unused data can be extremely challenging. Microarray or gene-chip experiments, for example, generate tens of thousands of pieces of information. Because most scientific journals require the authors to submit all of their data to publicly available international

Contact: Robert Dicks
Stanford University Medical Center

Page: 1 2 3

Related biology news :

1. Stanford/Packard scientists data-mining technique strikes genetic gold
2. Drug treatment improves learning in mice with Down syndrome symptoms, Stanford/Packard study shows
3. Researchers discover way to make cells in the eye sensitive to light
4. Researchers find how protein allows insects to detect and respond to pheromones
5. Researchers Uncover Key Step In Manufacture of Memory Protein
6. NYU researchers simulate molecular biological clock
7. Researchers reveal the infectious impact of salmon farms on wild salmon
8. Researchers identify target for cancer drugs
9. Vital step in cellular migration described by UCSD medical researchers
10. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
11. UCSD researchers maintain stem cells without contaminated animal feeder layers
Post Your Comments:
(Date:10/2/2015)... DUBLIN , Oct. 02 2015 ... addition of the "Enforcing the Law Using ... ) has announced the addition of ... report to their offering. --> Research ... addition of the "Enforcing the Law Using ...
(Date:9/30/2015)... GARDENS, Fla. , Sept. 30, 2015  The ... this month issued another key ruling in favor of ... determination that Korean fingerprint scanner company Suprema and its ... Act of 1930, a trade provision that declares it ... import trade, by infringing two of Crossmatch,s patents, the ...
(Date:9/29/2015)... MILWAUKEE , Sept. 29, 2015  iDAvatars is excited ... partners to introduce its product to market. The official announcement was ... Cognitive Economy event in San Francisco ... Avatar platform powered by IBM Watson. "It is ... the first 100 companies to bring to market the cognitive ...
Breaking Biology News(10 mins):
... 16 issue of the journal Cell Host & ... this immune response in mice infected with lymphocytic choriomeningitis ... of drug treatments for immunosuppressive diseases in humans. ... of the interferon response in vivo," says the paper,s ...
... at the University of Delaware have discovered that when the ... it can send out an S.O.S. to the roots for ... that brings beneficial bacteria to the rescue. The finding ... of passing pathogens--and sheds new light on a sophisticated signaling ...
... TALLAHASSEE, Fla. -- The discovery of a protein involved ... a researcher at the Florida State University College of ... Institutes of Health. Branko Stefanovic, associate professor in ... Medicine, hopes his discovery could lead to treatment methods ...
Cached Biology News:
(Date:10/8/2015)... , Oct. 8, 2015  ATCC, the premier global ... it has been selected by The Michael J. Fox ... lines to academic, pharmaceutical, and biotechnology organizations committed to ... the United States , and more than ... the United States , and more than ...
(Date:10/8/2015)... Global Biologics and Biosimilars ... Biosimilars industry . --> Big Market ... Industry 2015 Deep Market Research Report, Size, Share, ... and depth research report on Global Biologics ... , --> ) , ...
(Date:10/8/2015)... 8, 2015 /PRNewswire/ - RepliCel Life Sciences Inc. (OTCQB: REPCF) ... on the development of autologous cell therapies, today announced its ... taking place in the month of October: ... RepliCel will be presenting at the annual Partnering ... Mesa to be held October 7-9 in ...
(Date:10/8/2015)... ... October 08, 2015 , ... ProMIS Neurosciences, ... agreement to develop and commercialize intellectual property rights belonging to The University of ... 2009, and affords exclusive worldwide rights to intellectual property based on use of ...
Breaking Biology Technology:
... , Purpose , ... the use of chloramphenicol (CAP) as a veterinary drug for food ... for the identification and quantification of CAP in milk and milk ... many analytical procedures are described in the literature, the presented method ...
... , ... and detailed structural data of highlyknotted spider toxins , ... The primary structure determination ... cLC 492 sequencing system and the QSTAR Pulsar hybrid quadrupole time-of-flight mass spectrometer. ...
... Abstract , The generation of hybrid ... production is a fundamental and well-established technique. However, , ... , has varied little over the years. ... antigens is particularly problematic. We have developed a robust , ...
Cached Biology Technology: