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Stand Up to Cancer and Melanoma Research Alliance announce dream team
Date:12/14/2011

e gene. Very little progress has been made to identify new therapeutic targets to treat patients with BRAFwt metastatic melanoma.

This Dream Team will investigate the utility of personalized target/therapy identification in patients with BRAFwt metastatic melanoma and will explore the efficacy of molecularly guided therapy involving numerous Food and Drug Administration-approved and investigational agents. Team members will molecularly profile BRAFwt and BRAF-mutant cell lines and test for sensitivity to 100 prioritized compounds that might translate into therapeutic utility. Researchers will use these data to generate models that predict the sensitivity of BRAFwt melanomas to specific drugs. They will test these predictions using xenografts of the melanoma cell lines and primary tumors. An ensuing clinical trial will determine whether this personalized approach significantly improves clinical outcome. The goal is a 30-percent improvement in tumor response relative to standard-of-care therapy.

The target for the start of clinical trials is estimated at mid-2012. To inquire about clinical trials, e-mail MelanomaDreamTeam@karmanos.org.

The team hopes that an individualized medicine approach to the treatment of BRAFwt metastatic melanoma will not only lead to therapeutic benefit for this patient population but may also be beneficial to many other tumor and disease types.

Dream Team Selected Through Rigorous, Interactive Process

"The collaboration between Trent, an expert in human cancer genetics, and LoRusso, a clinician and clinical trialist, exemplifies the types of expertise SU2C brings together in hoping to move science from bench to bedside where it can benefit patients quickly," said Nobel Laureate Phillip A. Sharp, Ph.D., institute professor at the David H. Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology.

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Contact: Adam Pockriss
Apockriss@Rubenstein.com
212-843-8286
American Association for Cancer Research
Source:Eurekalert  

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