Navigation Links
Stable plaque or heart attack plaque? USC researcher builds new sensor to tell which is which
Date:11/23/2009

University of Southern California biomedical engineer and cardiologist Tzung "John" Hsiai hopes to develop a new tool to help clinicians distinguish cardiac emergencies requiring immediate surgery from chronic problems manageable with drugs and lifestyle change.

Angiograms, images made by catheters inserted into the arteries feeding the heart, offer an inside view of the interior surface ("lumen") of these blood vessels, often revealing deposits of a dangerous fatty substance called plaque.

But plaque comes in different forms. Some are metabolically stable and firmly fixed in the lumen and treatable with diet, exercise and medication. Others are less viscous and likely high risks to dislodge and cause heart attacks. These require immediate primary coronary intervention (angioplasty) or by-pass surgery.

The problem: current angiogram techniques cannot distinguish the types. "Distingishing stable from unstable plaque remains an unmet clinical challenge," said Hsiai, who holds both M.D. and Ph.D. degrees.

He hopes that the new Microelectromechanical System (MEMS) sensor his lab has created can change this situation.

The MEMS system uses minute heat perturbations as a proxy for blood flow and detects changes in bulk resistance for plaque characteristics.

The lab has demonstrated that this sensor can make the distinction between stable and unstable plaque in laboratory examinations of specimens of plaque clogged arteries extracted from rabbits fed a special plaque-producing diet

Another configuration of the same sensors can measure the forces on the artery walls produced by blood flows, identifying spots where back currents may be promoting plaque formation.

The next step will be to embed the MEMS sensors into angiogram catheters, and show that they can accurately make the same distinctions, first in animals, then in human subjects.

Every year, approximately one million Americans undergo angiograms, according to the National Institutes of Health. Heart attacks are the leading cause of deaths in the United States, accounting for approximately one-fifth of total annual mortality according to the American Hearth Association.

And "coronary artery disease is rising worldwide because of changes in diet in developing nations, and parallel increases in obesity and diabetes in the West," said Hsiai.

Hsiai's lab recently received a funding in American Recovery and Reinvestment Act (ARRA) funds from the National Institutes of Health to pursue the research.


'/>"/>

Contact: Eric Mankin
mankin@usc.edu
213-821-1887
University of Southern California
Source:Eurekalert  

Related biology news :

1. Dr. Andrew Constable awarded 2008 Pew Fellowship in marine conservation
2. Trading energy for safety, bees extend legs to stay stable in wind
3. Evolution still scientifically stable
4. A novel way found to prevent protein plaques implicated in Alzheimers
5. Researchers close in on origins of main ingredient of Alzheimers plaques
6. Anti-inflammatory drug blocks brain plaques
7. Scientists demonstrate means of reducing Alzheimers-like plaques in fly brain
8. Lower your blood pressure, hydrate your skin and reduce dental plaque -- with chocolate?
9. Impaired energy metabolism linked with initiation of plaques in Alzheimers brain
10. Scientists remove amyloid plaques from brains of live animals with Alzheimers disease
11. Abnormal fat metabolism underlies heart problems in diabetic patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stable plaque or heart attack plaque? USC researcher builds new sensor to tell which is which
(Date:5/9/2016)... , UAE, May 9, 2016 ... it comes to expanding freedom for high net worth ... Even in today,s globally connected world, there is still ... system could ever duplicate sealing your deal with a ... second passports by taking advantage of citizenship via investment ...
(Date:4/26/2016)... , April 27, 2016 ... the  "Global Multi-modal Biometrics Market 2016-2020"  report to ... ) , The analysts forecast the ... CAGR of 15.49% during the period 2016-2020.  ... number of sectors such as the healthcare, BFSI, ...
(Date:4/13/2016)... , April 13, 2016  IMPOWER physicians supporting ... are setting a new clinical standard in telehealth thanks ... By leveraging the higi platform, IMPOWER patients can routinely ... pulse and body mass index, and, when they opt ... and convenient visit to a local retail location at ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle Marche in ... peritoneal or pleural mesothelioma. Their findings are the subject of a new article on ... biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma patients that ...
(Date:6/23/2016)...   Boston Biomedical , an industry leader ... target cancer stemness pathways, announced that its lead ... Designation from the U.S. Food and Drug Administration ... gastroesophageal junction (GEJ) cancer. Napabucasin is an orally ... stemness pathways by targeting STAT3, and is currently ...
(Date:6/23/2016)... HOUSTON , June 23, 2016 ... agreement with the Cy-Fair Sports Association to serve ... of the agreement, Houston Methodist Willowbrook will provide ... education and connectivity with association coaches, volunteers, athletes ... partner with the Cy-Fair Sports Association and to ...
(Date:6/23/2016)... 23, 2016  The Biodesign Challenge (BDC), a university ... to harness living systems and biotechnology, announced its winning ... New York City . ... showcased projects at MoMA,s Celeste Bartos Theater during the ... MoMA,s senior curator of architecture and design, and ...
Breaking Biology Technology: