Navigation Links
Stable plaque or heart attack plaque? USC researcher builds new sensor to tell which is which
Date:11/23/2009

University of Southern California biomedical engineer and cardiologist Tzung "John" Hsiai hopes to develop a new tool to help clinicians distinguish cardiac emergencies requiring immediate surgery from chronic problems manageable with drugs and lifestyle change.

Angiograms, images made by catheters inserted into the arteries feeding the heart, offer an inside view of the interior surface ("lumen") of these blood vessels, often revealing deposits of a dangerous fatty substance called plaque.

But plaque comes in different forms. Some are metabolically stable and firmly fixed in the lumen and treatable with diet, exercise and medication. Others are less viscous and likely high risks to dislodge and cause heart attacks. These require immediate primary coronary intervention (angioplasty) or by-pass surgery.

The problem: current angiogram techniques cannot distinguish the types. "Distingishing stable from unstable plaque remains an unmet clinical challenge," said Hsiai, who holds both M.D. and Ph.D. degrees.

He hopes that the new Microelectromechanical System (MEMS) sensor his lab has created can change this situation.

The MEMS system uses minute heat perturbations as a proxy for blood flow and detects changes in bulk resistance for plaque characteristics.

The lab has demonstrated that this sensor can make the distinction between stable and unstable plaque in laboratory examinations of specimens of plaque clogged arteries extracted from rabbits fed a special plaque-producing diet

Another configuration of the same sensors can measure the forces on the artery walls produced by blood flows, identifying spots where back currents may be promoting plaque formation.

The next step will be to embed the MEMS sensors into angiogram catheters, and show that they can accurately make the same distinctions, first in animals, then in human subjects.

Every year, approximately one million Americans un
'/>"/>

Contact: Eric Mankin
mankin@usc.edu
213-821-1887
University of Southern California
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Dr. Andrew Constable awarded 2008 Pew Fellowship in marine conservation
2. Trading energy for safety, bees extend legs to stay stable in wind
3. Evolution still scientifically stable
4. A novel way found to prevent protein plaques implicated in Alzheimers
5. Researchers close in on origins of main ingredient of Alzheimers plaques
6. Anti-inflammatory drug blocks brain plaques
7. Scientists demonstrate means of reducing Alzheimers-like plaques in fly brain
8. Lower your blood pressure, hydrate your skin and reduce dental plaque -- with chocolate?
9. Impaired energy metabolism linked with initiation of plaques in Alzheimers brain
10. Scientists remove amyloid plaques from brains of live animals with Alzheimers disease
11. Abnormal fat metabolism underlies heart problems in diabetic patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stable plaque or heart attack plaque? USC researcher builds new sensor to tell which is which
(Date:9/30/2014)... DURHAM, N.C. -- Pollution in urban and farm runoff ... a new study finds. , The study, published ... shows that nitrogen in the runoff ends up in ... tumors on the animals, eyes, flippers and internal organs. ... and the National Oceanic and Atmospheric Administration (NOAA) conducted ...
(Date:9/30/2014)... your doctor to know what goes wrong with your muscles ... to know what "normal" actually is. That,s where a new ... FASEB Journal comes in. In the ... set of molecules that can help scientists "see" which genes ... more, they found never-before-detected gene activity and that men have ...
(Date:9/30/2014)... 30, 2014  Spectra Automation, a trusted ... biotech and power generation industries, announced today ... Manager, an easy-to-use and cost-effective data collection, ... development laboratories. Most upstream ... analyzer systems. Accessing and consolidating data from ...
Breaking Biology News(10 mins):Pollution linked to lethal sea turtle tumors 2Pollution linked to lethal sea turtle tumors 3Scientists identify which genes are active in muscles of men and women 2Spectra Automation Introduces RECONN Bioprocess Manager 2
... been named among the nation,s most innovative users of ... has been announced and can be viewed at ... the nation,s most innovative users of information technology and ... some of the best-known organizations in the country. Past ...
... With only two weeks to go and almost a ... 2013 have reached their final stages. This year,s conference ... Simons will deliver the opening keynote lecture and explain ... cells work. In further keynote lectures, Hans Clevers will ...
... Sept. 8, 2013 An ambitious partnership among more ... & Gamble,s (P&G,s) nonprofit program, Children,s Safe ... 6 billion quarts of clean drinking water to families ... they,re just getting started. CSDW Manager Allison Tummon ...
Cached Biology News:All set for The EMBO Meeting 2013 2Water-purification plant the size of a fast-food ketchup packet saves lives 2
(Date:10/1/2014)... Foster City, CA (PRWEB) October 01, 2014 ... century, it leaves no room for doubt that this century ... and innovations in the field of medicine science. The fact ... health problems is not unknown to the scientific community. Almost ... and pollution and therefore can be prevented with medical care ...
(Date:10/1/2014)... BOSTON, MA (PRWEB) September 30, 2014 ... company, SoundConnect announces four new-hosted collaboration ... innovative bundles deliver high quality conferencing experiences for ... collaboration packages to choose from, businesses have optimized ... bundled solutions include audio only minutes ...
(Date:10/1/2014)... October 1, 2014 Industry ... invited to engage around the theme, ,Commercial Opportunities in ...   Elsevier , a world-leading ... services, will host a gathering of some of the ... trends impacting healthcare today and in the future. The ...
(Date:9/30/2014)... Pacific Northwest Biotechnology, LLC - Product ... Markets Direct,s, ,Pacific Northwest Biotechnology, LLC - Product ... the Pacific Northwest Biotechnology, LLC,s pharmaceutical research and ... on the current therapeutic developmental pipeline of Pacific ... various stages, therapeutics assessment by drug target, mechanism ...
Breaking Biology Technology:Fighting Mortality and Morbidity of Chronic Health Disorders during Open Access Week 2Fighting Mortality and Morbidity of Chronic Health Disorders during Open Access Week 3SoundConnect Launches New Audio, Web and Video Bundles 2Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 2Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 3Pacific Northwest Biotechnology, LLC - Product Pipeline Review - 2014 2Pacific Northwest Biotechnology, LLC - Product Pipeline Review - 2014 3
... 18, 2011 Ingenuity® Systems, a leading provider ... Erasmus Medical Center, jointly announced a scientific collaboration ... As part of the collaboration, Erasmus ... derive the most impactful biological insights from their ...
... German . , At the beginning of the ... for use of the first thiol-based self-assembling monolayers (SAMs). Nanotechnology ... now honored with the Research Award of the Alexander von ... of Functional Interfaces (IFG) at KIT and the Bielefeld Institute ...
... Jan. 14, 2011 Dendreon Corporation (Nasdaq: ... offering of $540 million aggregate principal amount of 2.875% ... in an offering registered under the Securities Act of ... from its previously announced $500 million offering.  The Notes ...
Cached Biology Technology:Ingenuity Systems and Erasmus University Medical Center Collaborate on Next-Generation Sequencing Project to Accelerate Disease Research 2New impulses for surface research 2Dendreon Announces Pricing of $540 Million Convertible Senior Notes Due 2016 2Dendreon Announces Pricing of $540 Million Convertible Senior Notes Due 2016 3Dendreon Announces Pricing of $540 Million Convertible Senior Notes Due 2016 4
... I from vaccinia virus is a type ... and negative superhelical turns (also called right- ... The product of the reaction is a ... or negative superhelical turns. DNA Topoisomerase I ...
... The CpGenome Fast DNA Modification Kit contains ... on a DNA sample. In the bisulfite ... sulfonated, converting them to uracils, while 5-methylcytosines ... treated DNA will differ depending on whether ...
... Molecular Probes EnzChek Pyrophosphate Detection ... spectrophotometric,method for measuring the inorganic pyrophosphate ... biochemical reactions, such as DNA and,RNA ... enzyme,adenylate cyclase and the enzymatic activation ...
... high PCR specificity *High PCR specificity ... enzyme with unique QIAGEN PCR Buffer ... provided by the stringent built-in hot ... Master Mix and simple reaction setup ...
Biology Products: