Navigation Links
Stabilizing force for good communication between neurons and muscle cells found
Date:10/9/2008

You can't raise a finger without your brain directing muscle cells, and scientists have figured out another reason that usually works so well.

A neuron sends a message, or neurotransmitter, to the muscle cell to tell it what to do. To get the message, the receiving cell must have a receptor. Oddly, the unstable protein rapsyn is responsible for anchoring the receptor so it's properly positioned to catch the message.

Medical College of Georgia scientists have found what keeps rapsyn in proper conformation.

It is a heat shock protein, one of a large family of molecular chaperones that make sure proteins get where they are needed and do what they should, says Dr. Lin Mei, chief of developmental neurobiology at MCG and Georgia Research Alliance Eminent Scholar in Neuroscience.

Hsp90β helps stabilize rapysn so receptors can get and stay where needed, according to research published in the Oct. 9 issue of Neuron. Dr. Mei suspects that other hsp siblings have a similar caretaker role in neuron-to-neuron communication in the brain.

Scientists knew rapsyn's role in getting neuromuscular receptors to aggregate and stay where needed, but they didn't know what stabilized it. "It makes you wonder how to control this naughty boy which is very important," says Dr. Mei, the study's corresponding author.

They found hsp90β wherever rapsyn clustered in muscle cells. When they disrupted its activity or expression, they realized hsp90β's stabilizing role in forming and maintaining receptor clusters, says Dr. Shiwen Luo, postdoctoral fellow in Dr. Mei's lab and the study's first author. Rapsyn and the receptor apparently interact, then hsp90β comes along to help stabilize the relationship.

Rapsyn mutations have been implicated in muscular dystrophies including congenital myasthenia gravis. MCG researchers are looking now to see if a mutated rapsyn still interacts with hsp90β.


'/>"/>
Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Bioengineers at University of Pennsylvania devise nanoscale system to measure cellular forces
2. Europe needs collective effort on System Biology, says ESF Task Force
3. Louisiana Tech researchers investigate tracking, sensors to assist Air Force
4. New technique reveals subtle force-induced changes in biomolecules conformation
5. Springer and the New York Botanical Garden Press join forces to publish botanical journals
6. US Army, US Navy, US Air Force, US Marines, US Department of Defense conference held at UH
7. Wireless Public Safety Solution From BIO-key(R) and DaProSystems Links Virginia Law Enforcement Agencies
8. BIO-key(R) Awarded Mobile Data Contract for Additional 10 Kentucky Law Enforcement Agencies
9. Coastal management cooperation, enforcement key to avoid pending crisis for millions: U.N. experts
10. Coastal management cooperation, enforcement key to avoid pending crisis for millions: UN experts
11. VIB and Bayer join forces for plant research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stabilizing force for good communication between neurons and muscle cells found
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced ... India 2015-2019" report to their offering. ... market is the adoption of multimodal biometric systems. ... of an individual for verification and identification purposes. ...
(Date:12/11/2014)... , Dec. 10, 2014  Data Sciences ... monitoring, has released a new series of digital ... preclinical toxicology researchers. M series, part of the ... collect the best possible physiologic data when incorporating ... Adding functional endpoints to toxicology studies has evolved ...
(Date:12/10/2014)... , Dec. 9, 2014  Valencell, a leader ... is seeing a staggering demand from its licensees for ... Company revealed, is not solely coming from fitness and ... well. "A wearable is only as useful ... accuracy is the ultimate driver in long-term mass consumer ...
Breaking Biology News(10 mins):Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2New telemetry implants expected to change how large animal toxicology studies are conducted 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2
... release is available in French . ... Vice-Chancellor of Concordia University, is pleased to announce the ... solar simulator. The Environmental Chamber will be built through ... Governments, through the Knowledge Infrastructure Program. The Environmental ...
... , This release is available in ... Vice-Chancellor of Concordia University is pleased to announce the ... Structural and Functional Genomics (CSFG). The Centre will ... the Federal and Provincial Governments through the Knowledge Infrastructure ...
... activity levels fall and rise to the beat of our ... sleeping and feeding patterns to the energy available to our ... by light, the pacemakers in peripheral organs are set by ... Now, researchers at the Salk Institute for Biological Studies shed ...
Cached Biology News:Concordia University to build innovative Environmental Chamber 2Concordia University to construct new building for genomics research 2The food-energy cellular connection revealed 2The food-energy cellular connection revealed 3
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... /PRNewswire/ - Inimex Pharmaceuticals, Inc. announced today that it has ... , Abrams brings more than 25 years of drug discovery ... the nuclear medicine imaging agent, Cardiolite, and worked from 1984 ... Biomedical Research Worldwide. In 1996, Abrams led the establishment of ...
... , , , , , ... , AUDIO: A team of scientists from Washington ... Click here for more information. , , ... , , , , , ...
... , , ROCKVILLE, Md., Nov. 20 ... it has priced an underwritten public offering of 6,800,000 shares ... of $3.30 per share. The approximately $21 million of ... be used for preclinical studies and clinical trials of our ...
Cached Biology Technology:Inimex Announces Appointment of New CEO 2Amaizing: Corn genome decoded 2Amaizing: Corn genome decoded 3Amaizing: Corn genome decoded 4Novavax Prices Public Offering of Common Stock 2
Rabbit polyclonal to Peptide E ( Abpromise for all tested applications)....
Mouse monoclonal [6911] to E. coli K99 pilus ( Abpromise for all tested applications)....
...
...
Biology Products: