ST. LOUIS - Researchers at the Saint Louis University School of Medicine have discovered the key brain chemical that causes Parkinsons disease a breakthrough finding that could pave the way for new, far more effective therapies to treat one of the most common and debilitating neurological disorders.
Currently, the main approach for treating Parkinsons disease, which afflicts more than 1.5 million Americans, is to replace dopamine thats lost when the cells that produce it die off and cause the disorder. With this new research, however, scientists can better work toward neuroprotective therapies those that actually block dopamine cells from dying off in the first place.
We believe this work represents a very significant breakthrough in understanding the complicated chemical process that results in Parkinsons disease, said William J. Burke, M.D., Ph.D., professor of neurology at the Saint Louis University School of Medicine and the studys lead author.
For the first time, weve identified the chemical that triggers the events in the brain that cause this disorder, Burke added. We believe these findings can be used to develop therapies that can actually stop or slow this process.
The scientists findings are published in an early online edition of the journal Acta Neuropathologica (http://www.springerlink.com/content/y875t47212001762/fulltext.html).
The researchers at Saint Louis University were joined in their effort by a team from Washington University in St. Louis.
Parkinsons disease occurs when some nerve cells in a part of the brain called the substantia nigra die or become impaired. Normally, these cells produce dopamine a vital chemical that allows smooth, coordinated function of the bodys muscles and movements.
When about 80 percent of these dopamine-producing cells die or are damaged, the symptoms of Par
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Saint Louis University