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St. Jude study gives new insights into how cells accessorize their proteins
Date:9/18/2008

s with NEDD8 and cullin-RING have broader significance for detailed understanding of the workings of the intricate ubiquitination machinery.

"The whole process of attaching ubiquitinor any of this family of UBLsto their targets involves moving a protein onto other proteins to regulate their activity," she said. "And in many cases, this process is probably regulated by just the kind of conformational change that our findings reveal. So, we believe that these findings offer overall insight into how conformational change can activate these kinds of ligases."


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Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

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