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St. Jude settles century-old debate on origin of mammalian network of lymphatic vessels
Date:10/3/2007

a main contributor to development of the mammalian lymphatic vasculature, according to Oliver.

We showed that venous-derived LECs sprout from the lymph sacs, multiply and then migrate to their ultimate destination to give rise to the entire lymphatic vasculature; and that hematopoietic cells do not contribute significantly to this process, said R. Sathish Srinivasan, Ph.D. Therefore, we concluded that in mammals, such as mice and humans, the lymphatic vasculature arises directly and solely from the embryonic veins. Srinivansan is a postdoctoral fellow in Olivers laboratory and did most of the work on this project.

This finding supports the original theory presented in the early 20th century by the eminent researcher Florence Sabin, who proposed that the origin of the mammalian lymphatic vasculature is the venous system, Oliver said. She didnt have the technology to prove her idea back then. We did it for her 100 years later.


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Contact: Summer Freeman
summer.freeman@stjude.org
901-495-3061
St. Jude Children's Research Hospital
Source:Eurekalert

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