Navigation Links
St. Jude influenza survey uncovers key differences between bird flu and human flu
Date:8/20/2007

m identified 32 specific locations in proteins where a gene mutation caused the existing amino acid to be substituted with a different amino acid. What made these 32 changes special was that influenza from birds differed from the influenza that was in humans. After the avian influenza infected humans, the amino acid changes are stable in the proteins and remain stable over time. Therefore, these markers can be used to distinguish influenza viruses that infect birds from those that infect humans.

The researchers discovered these markers by computationally surveying the sequence of amino acids in 10,671 proteins from avian influenza viruses and 13,757 proteins from human influenza viruses. The survey identified 32 persistent markers that exist in five bird and human virus proteins: PA, NP, M1, NS1 and PB2. These markers stand out as obvious differences between bird and human viruses, and many appear in regions where host protein and viral replication occur. The researchers did not determine what functional role the markers play in the life of the viruses.

For example, 26 of the 32 markers discovered are found in NP, PB2 and PA, which help to form a complex of proteins critical for the replication of virus genes. The other six persistent host markers are in M1 and NS1 proteins. M1 is known to bind to a protein in cells that enhances the replication of viruses; and NS1 plays a role in suppressing the host immune response. Therefore, the markers in M1 and NS1 might represent key mutations needed to improve the ability of the virus to suppress the immune system and enhance viral replication.

The St. Jude team also studied markers in influenza viruses that caused pandemics in 1918, 1957 and 1968outbreaks thought to have been caused by avian influenza viruses that adapted to humans. The study focused on the viruses isolated from humans early in each pandemic in order to determine which markers the viruses had recently acquired just before t
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-495-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Computers to be used to find blueprint for new influenza drug
2. Influenza vaccine uses insect cells to speed development
3. Drug resistant avian influenza viruses more common in Southeast Asia than North America
4. Genome Sequence for Haemophilus Influenzae Completed
5. Less virulent strains of avian influenza can infect humans
6. Confronting Influenza: Are We Prepared?
7. New vaccine platform may fight infections with causes from influenza to bioterrorism
8. First big influenza genome study reveals flu evolution
9. Web model of influenza-host lifecycles will aid scientists in creating anti-viral drugs
10. New influenza vaccine takes weeks to mass produce
11. Study outlines genetic differences between potential pandemic influenza strains
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... In the current eight ... the strongest competitors, showing outstanding performance in recognition ... is capable of a throughput of 5.000.000 fingerprints ... be ten times faster than most competitors and ...      (Photo: http://photos.prnewswire.com/prnh/20150402/738673-a ) , ...
(Date:4/1/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... mobile commerce market, announces the second shipment of a ... early access pre-order customers. Feedback from ... including Walmart, Target, AT&T, Dunkin, Donuts, Stop & Shop ... all outlets and very easy to use. Several users ...
(Date:3/30/2015)... 26, 2015 Research and Markets ( ... "Global Gesture Recognition Market in Automotive Sector 2014-2018" ... the Global Gesture Recognition market in Automotive Sector to ... 2013-2018. Gesture recognition is the ability of ... of an individual. Gesture recognition technology can be 2D-based ...
Breaking Biology News(10 mins):DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2
... with the current poaching rates. The loss of this megaherbivore is ... on the ecosystems they now live in. The white ... of ecosystem functioning because theyre not controlled by predation. A ... Journal of Ecology , highlights the role of the white ...
... better be sure that there are no great tits around to ... So says Anders Brodin and Utku Urhan of the University of ... position of such hideaways up to 24 hours after seeing it ... well-known hoarders such as crows and jays, they do not store ...
... genetic traits in cattle that might allow farmers to ... The study, which compared the genetic code of ... to impact on a disease that leads to major ... University of Edinburgh,s Roslin Institute, has identified a number ...
Cached Biology News:Poaching threatens savannah ecosystems 2"You hide it -- I'll find it!" -- Great tit has a bird's eye view when looking for dinner 2Genetic find might lead to cattle that are more resistant to TB 2
(Date:4/30/2015)... 30, 2015 Nitto Avecia, a ... its increased capacity and production capability to serve ... variety and service fulfillment continues to drive Nitto ... process throughput capacities. , In Fall ... downstream process equipment at its Milford, MA facility, ...
(Date:4/30/2015)... , April 30, 2015 The following is an ... Directors of China Cord Blood Corp (NYSE: CO ) ... committee of the independent directors of China Cord Blood Corp ... offer of $6.40 per share from Golden Meditech Holdings Co ... per share would greatly benefit Golden Med and Mr. Kam, ...
(Date:4/30/2015)...  The Paul G. Allen Family Foundation announced today ... six groups of researchers with projects at the frontier ... growing mature human brain cells in the laboratory. The ... over three years.  "This new cohort ... significant because the field of neuronal maturation is at ...
(Date:4/30/2015)... 2015  Asterias Biotherapeutics, Inc. (NYSE MKT: AST), a ... medicine, today announced that it will release first quarter ... after the close of the U.S. financial markets. The ... Thursday, May 7, 2015 at 4:30 p.m. Eastern / ... corporate developments. For both "listen-only" participants and ...
Breaking Biology Technology:Biotechnology Manufacturer Nitto Avecia Expands Capacity to Meet Client Demand 2April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 2April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 3April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 4April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 5The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 2The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 3The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 4The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 5Asterias Biotherapeutics to Report First Quarter Results on May 7, 2015 2Asterias Biotherapeutics to Report First Quarter Results on May 7, 2015 3
... PAREXEL International,Corporation (Nasdaq: PRXL ), ... Imogene Grimes, Ph.D., to Vice President of,Data ... biostatistician,with more than 25 years of experience, ... data science services, including data management,biostatistics, and ...
... LLC announced today,that it is teaming up with ... diabetes screenings to school age children in the ... pre-diabetic children and,adolescents. Beginning May 1, 2008 and ... be available free of charge at any of ...
... FRANCISCO, Calif., April 29 ,Anesiva, Inc. (Nasdaq: ... and distribution agreement, with Green Vision Company, for,several ... injection system is approved in the U.S. to,provide ... or blood,draws in children three to 18 years ...
Cached Biology Technology:PAREXEL Appoints Leading Biostatistician Dr. Imogene Grimes to Vice President of Data Sciences Strategic Services 2PAREXEL Appoints Leading Biostatistician Dr. Imogene Grimes to Vice President of Data Sciences Strategic Services 3PAREXEL Appoints Leading Biostatistician Dr. Imogene Grimes to Vice President of Data Sciences Strategic Services 4RediClinic, BIOSAFE Labs and Glycemion to Provide Free Diabetes Risk Assessments to Richmond, Va. School Children 2RediClinic, BIOSAFE Labs and Glycemion to Provide Free Diabetes Risk Assessments to Richmond, Va. School Children 3RediClinic, BIOSAFE Labs and Glycemion to Provide Free Diabetes Risk Assessments to Richmond, Va. School Children 4RediClinic, BIOSAFE Labs and Glycemion to Provide Free Diabetes Risk Assessments to Richmond, Va. School Children 5Anesiva Announces New Zingo Marketing and Distribution Agreement 2Anesiva Announces New Zingo Marketing and Distribution Agreement 3
RAT ANTI MOUSE METALLOPHILIC MACROPHAGES...
... All MagCellect Ferrofluid products ... conjunction with R&D Systems MagCellect ... capacities, this neodymium iron boron ... 12 x 75 mm test ...
Request Info...
Form: Concentrated Applications: ELISA...
Biology Products: