Navigation Links
St. Jude influenza survey uncovers key differences between bird flu and human flu
Date:8/20/2007

m identified 32 specific locations in proteins where a gene mutation caused the existing amino acid to be substituted with a different amino acid. What made these 32 changes special was that influenza from birds differed from the influenza that was in humans. After the avian influenza infected humans, the amino acid changes are stable in the proteins and remain stable over time. Therefore, these markers can be used to distinguish influenza viruses that infect birds from those that infect humans.

The researchers discovered these markers by computationally surveying the sequence of amino acids in 10,671 proteins from avian influenza viruses and 13,757 proteins from human influenza viruses. The survey identified 32 persistent markers that exist in five bird and human virus proteins: PA, NP, M1, NS1 and PB2. These markers stand out as obvious differences between bird and human viruses, and many appear in regions where host protein and viral replication occur. The researchers did not determine what functional role the markers play in the life of the viruses.

For example, 26 of the 32 markers discovered are found in NP, PB2 and PA, which help to form a complex of proteins critical for the replication of virus genes. The other six persistent host markers are in M1 and NS1 proteins. M1 is known to bind to a protein in cells that enhances the replication of viruses; and NS1 plays a role in suppressing the host immune response. Therefore, the markers in M1 and NS1 might represent key mutations needed to improve the ability of the virus to suppress the immune system and enhance viral replication.

The St. Jude team also studied markers in influenza viruses that caused pandemics in 1918, 1957 and 1968outbreaks thought to have been caused by avian influenza viruses that adapted to humans. The study focused on the viruses isolated from humans early in each pandemic in order to determine which markers the viruses had recently acquired just before t
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-495-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Computers to be used to find blueprint for new influenza drug
2. Influenza vaccine uses insect cells to speed development
3. Drug resistant avian influenza viruses more common in Southeast Asia than North America
4. Genome Sequence for Haemophilus Influenzae Completed
5. Less virulent strains of avian influenza can infect humans
6. Confronting Influenza: Are We Prepared?
7. New vaccine platform may fight infections with causes from influenza to bioterrorism
8. First big influenza genome study reveals flu evolution
9. Web model of influenza-host lifecycles will aid scientists in creating anti-viral drugs
10. New influenza vaccine takes weeks to mass produce
11. Study outlines genetic differences between potential pandemic influenza strains
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... VIEW, Calif. , Nov. 20, 2014 ... higher driver efficiency are piloting the North American and ... number of accidents growing, gesture recognition systems that are ... make a mark in the industry. ... the Automotive Gesture Recognition Market in Europe ...
(Date:11/21/2014)... 20, 2014   Atmel® Corporation (NASDAQ: ... and touch technology solutions, today launched the industry,s first ... the widest V cc range from 1.7V to ... faster I 2 C bus communication speeds, and are ... making them ideal for consumer, industrial, computer, and medical ...
(Date:11/18/2014)... , Nov. 17, 2014   ... EMC collaborate to develop The Partners Data Lake, ... The Partners Data Lake will allow researcher and ... diagnostics, treatment and the lives of patients ... and clinical activities across the Partners system, breaking ...
Breaking Biology News(10 mins):Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5
... fisheries certifier is failing on its promises as rapidly ... experts from the University of British Columbia (UBC), Scripps ... San Diego and elsewhere. Established in 1997 by ... world,s largest fish retailers, the Marine Stewardship Council (MSC) ...
... to watch the orderly and seemingly choreographed motion of ... However, the formation and the manifold motion patterns of ... of complex systems. A team of physicists from Technische ... versatile biophysical model system that opens the door to ...
... Mo. As the nation becomes more aware of ... are struggling to find ways to make healthy living ... healthy ideas into sustainable changes through the Healthy Lifestyle ... Missouri counties, is aimed at changing environments to increase ...
Cached Biology News:Seafood stewardship questionable: UBC-Scripps experts 2Seafood stewardship questionable: UBC-Scripps experts 3A model system for group behavior of nanomachines 2A model system for group behavior of nanomachines 3Resource-savvy communities generate healthy, sustainable changes 2
(Date:12/19/2014)... , Dec. 18, 2014 Egenix, Inc. is ... been elected Chairman of the Board, to succeed Donald ... CEO, but will continue as a member of the Board.  ... has added to the company over almost twenty years, the ... The Board of Directors has established a Search Committee to ...
(Date:12/17/2014)... USA (PRWEB) December 16, 2014 ... manager at Philipps- Universität Marburg’s Department of Physics, ... photonics, in the newly released SPIE Women ... never be too shy to ask questions.” , ... technology, engineering, and mathematics) occupations ranging from university ...
(Date:12/17/2014)... Indianapolis, IN (PRWEB) December 17, 2014 ... for Laboratory Excellence following its most recent COLA ... Accreditation by COLA, a national healthcare accreditation organization. ... rigid standards of quality in day-to-day operations, demonstrate ... and pass a rigorous on-site laboratory survey. ...
(Date:12/17/2014)... 17, 2014 CASI Pharmaceuticals, Inc. (Nasdaq: ... acquisition, development and commercialization of innovative therapeutics addressing cancer ... with a primary commercial focus on China ... a Type C meeting with the U.S. Food and ... held in February 2015.  During this meeting the Company ...
Breaking Biology Technology:Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 3Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 2CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 3CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 4CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 5
... Introduction , ... is fundamental to environmental protection. In addition to the obvious ... can help trace the source of a dangerous material and ... <P,>A substantial body of research has clearly established ...
... opaque, or solid samples such as blood, ... or phosphors, front-face fluorescence detection offers significant ... Highly concentrated and opaque liquids typically have ... the beam. When measuring fluorescence at 90, ...
... , ... , Fluorescence immunoassay is applied ... stimulation. Interference from other sample components is limited by use ... The detection system includes a T-format sampling module mounting two ...
Cached Biology Technology:Screening and classifying hazardous waste samples 2Screening and classifying hazardous waste samples 3Screening and classifying hazardous waste samples 4Screening and classifying hazardous waste samples 5Immunoassay of Theophylline by fluorescence polarisation 2Immunoassay of Theophylline by fluorescence polarisation 3Immunoassay of Theophylline by fluorescence polarisation 4Immunoassay of Theophylline by fluorescence polarisation 5Immunoassay of Theophylline by fluorescence polarisation 6
...
... silica based spin filter membrane to isolate DNA ... band is cut from an agarose gel and ... gel slice is melted irreversibly in a high ... to the silica spin filter membrane and washed ...
...
... Application: The greater incorporation of Br-dUTP ... cytometry when detected using a fluorescein-labeled anti-BrdU ... included in the kit to counterstain the ... of Br-dUTP, resulting in improved detection than ...
Biology Products: