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St. Jude identifies the specific cell that causes eye cancer, disproving long-held theory
Date:10/18/2007

aining all of the differentiated features of normal horizontal neurons.

As part of the study, the St. Jude team conducted microscopic and biochemical studies to prove that the multiplying cells were horizontal interneurons. Using such techniques, the researchers showed that as the horizontal interneurons multiplied their numbers up to 50-fold, they maintained their normal position in the retina as well as their normal connections to other cells.

If the horizontal interneuron cell division was allowed to proceed unchecked, highly differentiated tumors formed that resembled normal horizontal neurons. Unexpectedly, these tumors were aggressive and spread rapidly.

The investigators concluded that the Rb familys only task is to prevent mature horizontal interneurons from multiplying as they did when they were immature cells.


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Contact: Summer Freeman
summer.freeman@stjude.org
901-495-3061
St. Jude Children's Research Hospital
Source:Eurekalert

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