Navigation Links
St. Jude identifies the specific cell that causes eye cancer, disproving long-held theory
Date:10/18/2007

ltiply to form retinoblastoma also challenges the established scientific belief that cancer cells are most aggressive when they are undifferentiated, Dyer said. For example, the leukemic cells of chronic myelogeneous leukemia (CML) are much less aggressive when they are differentiated; and it is generally not aggressive until the tumor cells sustain mutations that block differentiation.

On the contrary, we showed that when certain genes are inactivated in the retina, horizontal neurons that are already differentiated and fully integrated into the brain can start multiplying rapidly and produce a very aggressive cancer, Dyer said. This opens an exciting new chapter in the study of neurons and brain tumors.

An important implication of this finding is that if researchers were able to alter the activity of certain genes in fully developed neurons, they might be able to trigger them to multiply temporarily and replace the neighboring neurons that were lost as a result of neurodegenerative diseases such as Alzheimers, Dyer said. Having nerves duplicate themselves might be more efficient than trying to stimulate nerve replacement by inserting stem cells into the brain, since the existing nerves would already be in the right place to restore missing brain cells, he said. However, there is still a lot of research required to determine if it is possible to control gene activity to make this approach practical.

Dyers group made their discovery by developing different populations of mice whose retinas lacked one or more members of the Rb family of genes that include Rb, p107 and p130. This family of related genes is critical to the ability of an immature cell to stop dividing and begin to differentiate so it acquires certain specific characteristics required to do its job in the body.

The St. Jude researchers showed that when the mouse retina had reduced Rb family function, fully differentiated horizontal neurons could multiply while ret
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-495-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
2. New lab technique identifies high levels of pathogens in therapy pool
3. Study identifies gene in mice that may control risk-taking behavior in humans
4. Researcher at UGA College of Veterinary Medicine identifies new way of combating viral diseases
5. U. of Colorado researcher identifies tracks of swimming dinosaur in Wyoming
6. Model identifies genes that induce normal skin cells to become abnormal
7. New study identifies key gene in development of connections between brain and spinal cord
8. New HIV study identifies high-risk subgroups of adolescents
9. Research identifies protein in mice that regulates bone formation
10. Study identifies new role for breast cancer susceptibility gene
11. New strategy rapidly identifies cancer targets
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... Wayne State University,s College of Engineering recently received ... for the project, "Nanoparticle-directed synthesis of organic nanorods." ... nanotechnology is the creation and utilization of functional ... functions. A major bottleneck in scaling up nanotechnology ... different functional materials into one device. A research ...
(Date:7/30/2014)... cells can develop into a multitude of cells types. Researchers ... the specific types of mature cells that make up the ... key seems to be long chains of sugars that dangle ... at the University of California, San Diego, has created synthetic ... can be more easily manipulated to direct the process, they ...
(Date:7/29/2014)... Bristol,s Nutrition and Behaviour Unit (NBU) has looked into ... meals. , The research, to be presented at the ... 2014) in Seattle, USA this week [29 July to ... was led by Professor Jeff Brunstrom, and is based ... of a Biotechnology and Biological Sciences Research Council (BBSRC) ...
Breaking Biology News(10 mins):NSF grant to Wayne State supports new concept for manufacturing nanoscale devices 2
... Hole Research Center are analyzing the surprising results of the ... rainforest. , From January 2000 to July 2004, rainfall was ... of the Tapajós National Forest, in Brazil. A total of ... by 6' clear plastic panels suspended 3 to 12 feet ...
... Affymetrix Inc. (Nasdaq: AFFX - News) and Karolinska ... a strategic alliance designed to improve healthcare by ... tools for better diagnosis, prognosis, and treatment. , ... genetic analyses and measurement of gene expression in ...
... have discovered an important chemical in the brain's ... symptoms of opioid drugs like morphine and heroin. ... chemical--called a transporter--could relieve some of the early ... shaking, and jumpiness. Such drugs could become part ...
Cached Biology News:World's largest rainforest drying experiment completes first phase 2World's largest rainforest drying experiment completes first phase 3Affymetrix and the Karolinska Institutet Announce Translational Medicine Strategic Alliance 2Affymetrix and the Karolinska Institutet Announce Translational Medicine Strategic Alliance 3Key Trigger Of Opioid Withdrawal Symptoms Found 2
(Date:7/30/2014)... EL SEGUNDO, Calif. , July 30, 2014 ... prime contractor on the Fully Integrated Lifecycle Mission ... Aeronautics and Space Administration (NASA). Under the terms ... to Ames Research Center at Moffett Field, Calif. ... management support for bioscience flight development projects on ...
(Date:7/30/2014)... BCC Research ( http://www.bccresearch.com ) reveals ... in Industrial Applications , the global market for industrial ... by 2018, registering a five-year compound annual growth rate ... recorded in the detergent enzyme segment with a CAGR ... has influenced almost every sector of industrial activity, ranging ...
(Date:7/30/2014)... July 30, 2014  Orexigen Therapeutics, Inc. (Nasdaq: ... Day 180 List of Outstanding Issues (LOI) from the ... Use (CHMP) for the NB32 Marketing Authorization Application (MAA). ... an investigational drug candidate being evaluated for weight loss. ... 120 time point were adequately addressed by the Company ...
(Date:7/30/2014)... SAN DIEGO , July 30, 2014   ... that designs and develops novel diagnostics to personalize and ... the appoint of Gregory T. Lucier as ... previously chairman and CEO of Life Technologies (formerly Invitrogen). ... expertise as Epic commercializes its circulating rare cell analysis ...
Breaking Biology Technology:Wyle Wins NASA's Fully Integrated Lifecycle Mission Support Services Contract 2Global Market for Industrial Enzymes to Reach Nearly $7.1 Billion by 2018; Detergent Enzyme Market to Record Maximum Growth 2Global Market for Industrial Enzymes to Reach Nearly $7.1 Billion by 2018; Detergent Enzyme Market to Record Maximum Growth 3Orexigen Receives CHMP Day 180 List of Outstanding Issues 2Orexigen Receives CHMP Day 180 List of Outstanding Issues 3Epic Sciences Appoints Greg Lucier as Chairman of the Board of Directors 2Epic Sciences Appoints Greg Lucier as Chairman of the Board of Directors 3
... Senate, my top priority has been growing the state's ... Committee on Job Creation, many pro-job initiatives authored and ... a bi-partisan basis. These bills have improved the state's ... built a foundation for a more vibrant venture capital ...
... University of Wisconsin-Madison faculty and staff interested in launching ... help them through the process of taking a good ... Business Ventures at the University of Wisconsin-Madison," is now ... of the UW-Madison Office of Corporate Relations (OCR). , ...
... even bigger businesses is the theme of the second-annual ... 1-2 in Milwaukee, conference organizers announced Wednesday. The event ... Wisconsin. , ,We must create an entrepreneurial culture in ... and create well-paying jobs, said Kelly Hansen, conference chairwoman ...
Cached Biology Technology:Broadband freedom mandatory for growth 2New guide offers assistance to UW-Madison entrepreneurs 2Entrepreneurs Conference to focus on strategies, tools and culture 2
... commonly used technique for studying protein function ... on SDS-PAGE and transferred to a membrane ... are probed with specific antibodies. Unlike nucleic ... Southern and Northern blots, it has been ...
... System, Basic Package Superior Protein Detection ... The ProXPRESS 2D Proteomic Imaging System is ... both proteomic and general life science research ... the use of all dyes in the ...
... our Regulatory Edition of Molecular Imaging (MI) ... for life science research and drug discovery ... with U.S. Food and Drug Administrations Code ... Electronic Records; Electronic Signatures [21 CFR Part ...
... OPA1-01009, OPEP-01009 is a 16 amino acid (amino acids 3-18) ... (DFF). The sequence of this peptide is (amino to ... S - V - K - L - R - ... R - K(18). This peptide may be used ...
Biology Products: