Navigation Links
St. Jude identifies genomic causes of a certain type of leukemia relapse
Date:11/27/2008

and be responsible for relapse."

According to the researchers, the relapse-related genetic changes commonly disrupted the machinery by which white blood cells called B cells mature and proliferate. Importantly, the relapse-related genetic changes only infrequently involved genes directly regulating the responsiveness to anti-cancer drugs.

The analysis also indicated that in most cases, the cancer cells responsible for relapse were related to those that originally gave rise to the cancer. Those relapse cells were present at low levels at diagnosis, the scientists' analysis indicated. However, in a few cases, the relapse cells evolved from genetically distinct cells, indicating that the relapsed leukemia was actually an entirely new cancer.

"The key finding in our work is that in the majority of cases, relapse is arising from a cell already present at the time of diagnosis," said James Downing, M.D., St. Jude Scientific Director, chair of the Department of Pathology and the paper's senior author. "That cell is selected for during treatment and then subsequently emerges as basis for relapse."

"The second key point is that we have found a large number of new genetic alterations that had not been previously identified as new targets of copy number changes at the time of relapse," Mullighan added.

Mullighan emphasized that the findings do not mean immediate treatments for ALL relapse. "But, this is a very important starting point because we have identified several key pathways that are the most common targets of new genetic changes at the time of relapse," he said.

Identification of these relapse pathways will lead to understanding of the biological machinery of relapse, and ultimately to drugs that target that machinery. Such studies of the relapse machinery are now underway at St. Jude.

In other further studies, the researchers are also looking for other relapse-related genetic alterations besides copy num
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. LSUHSC research identifies key contributor to Alzheimers disease process
2. Pitt research identifies new target in brain for treating schizophrenia
3. Research identifies type of vaccine that holds promise in protecting against TB
4. Conaway Lab identifies novel mechanism for regulation of gene expression
5. HPV DNA test identifies cervical pre-cancerous disease in developing countries with 90% success rate
6. New method identifies meth hot spots
7. Study identifies changes to DNA in major depression and suicide
8. UCLA study identifies mechanism behind mind-body connection
9. International team identifies 21 new genetic risk factors for Crohns disease
10. Stowers Institutes Shilatifard Lab identifies new role for factor critical to transcription
11. Rong Li Lab identifies new role of inflammatory protein in PKD and a possible treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... Washington, DCToday scientists unveiled the first high-resolution map ... the entire country of Per. The new and ... a sea change for future market-based carbon economies. ... extremely high ecological diversity and it provides the ... degradation for conservation, land use, and enforcement purposes. ...
(Date:7/29/2014)... in the University of Bristol,s Nutrition and Behaviour Unit ... into account when planning meals. , The research, to ... Ingestive Behavior Conference (SSIB 2014) in Seattle, USA this ... do. , The team was led by Professor Jeff ... Psychology. , As part of a Biotechnology and Biological ...
(Date:7/29/2014)... warms and sea ice retreats, the North is changing. ... open water which is predicted to extend across the ... Storms thus have the potential to create Arctic swell ... unpredictable element to the region. , A University of Washington ... middle of the Arctic Ocean, and detected house-sized waves ...
Breaking Biology News(10 mins):Peru's carbon quantified: Economic and conservation boon 2Peru's carbon quantified: Economic and conservation boon 3Huge waves measured for first time in Arctic Ocean 2Huge waves measured for first time in Arctic Ocean 3
... GEOLOGY ends 2012 with 23 new articles spanning ... Naica Cave, Mexico; Diamantina, Brazil; the Galpagos hotspot; China; ... central West Greenland; the California arc; the Pacific Ring ... Sierra Nevada; Spain; New Zealand; Turkey; Connecticut, USA; and ...
... the extinct giant piranha, or megapiranha, have the most ... body size is taken into account, finds researchers in ... The research paper, Mega-Bites: Extreme jaw forces of living ... which allows them to attack and bite chunks out ...
... RICHLAND, Wash. Pacific Northwest National Laboratory has been ... large amounts of renewable energy until it,s needed, fight ... to the marketplace. The Federal Laboratory Consortium announced ... Richland is receiving three 2013 Excellence in Technology Transfer ...
Cached Biology News:GEOLOGY returns to Naica Cave, Mexico, and extends its reach to Mercury 2GEOLOGY returns to Naica Cave, Mexico, and extends its reach to Mercury 3GEOLOGY returns to Naica Cave, Mexico, and extends its reach to Mercury 4GEOLOGY returns to Naica Cave, Mexico, and extends its reach to Mercury 5GEOLOGY returns to Naica Cave, Mexico, and extends its reach to Mercury 6GEOLOGY returns to Naica Cave, Mexico, and extends its reach to Mercury 7GEOLOGY returns to Naica Cave, Mexico, and extends its reach to Mercury 8GEOLOGY returns to Naica Cave, Mexico, and extends its reach to Mercury 9GEOLOGY returns to Naica Cave, Mexico, and extends its reach to Mercury 10GEOLOGY returns to Naica Cave, Mexico, and extends its reach to Mercury 11GEOLOGY returns to Naica Cave, Mexico, and extends its reach to Mercury 12GEOLOGY returns to Naica Cave, Mexico, and extends its reach to Mercury 13GEOLOGY returns to Naica Cave, Mexico, and extends its reach to Mercury 14GEOLOGY returns to Naica Cave, Mexico, and extends its reach to Mercury 15GEOLOGY returns to Naica Cave, Mexico, and extends its reach to Mercury 16GEOLOGY returns to Naica Cave, Mexico, and extends its reach to Mercury 17GEOLOGY returns to Naica Cave, Mexico, and extends its reach to Mercury 18GEOLOGY returns to Naica Cave, Mexico, and extends its reach to Mercury 19GEOLOGY returns to Naica Cave, Mexico, and extends its reach to Mercury 20Black piranha, megapiranha have most powerful bites of fish living or extinct, finds GW researcher 2PNNL recognized for transferring innovations to the marketplace 2PNNL recognized for transferring innovations to the marketplace 3
(Date:7/29/2014)... SoundConnect , an award winning ... to announce the strategic additions of implementation, support, ... Charleston and Atlanta offices. SoundConnect’s organizational expansion ... hosted solutions, collaboration and mobility that improve business ... SoundConnect was founded in 2004, with the mission ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 The advanced ... the brain that are driving a revolution in the ... new peer-reviewed journal published by SPIE, the international ... issue coincides with the launch of the BRAIN Initiative ... articles that lay out a vision for and provide ...
(Date:7/29/2014)... The Quantum Cheshire Cat: Can a particle be separated ... Nature Communications , published the results of the ... magnetic field, conducted by Chapman University in Orange, CA, ... often seen a cat without a grin," thought Alice ... the most curious thing I ever saw in my ...
(Date:7/29/2014)... , July 29, 2014  The Society ... new and updated program for the 9 th ... 12, 2014 in Amelia Island , Florida.  ... and investigators remains unchanged, however, the topics and ... and networking opportunity among all stakeholders with a ...
Breaking Biology Technology:SoundConnect Organization and Culture is Evolving 2SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 2SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 3SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 4The quantum Cheshire cat: Scientists separate a particle from its properties 2The quantum Cheshire cat: Scientists separate a particle from its properties 3The quantum Cheshire cat: Scientists separate a particle from its properties 4TransCelerate, Lilly, Pfizer, and FDA Highlight Collaborative Program at the Site Solutions Summit 2TransCelerate, Lilly, Pfizer, and FDA Highlight Collaborative Program at the Site Solutions Summit 3
... MADISON -- The same chemical reaction that causes iron to ... stress chips away at healthy cells and is a process, ... conditions in humans ranging from Alzheimer,s, heart disease and stroke ... writing in the current edition (Feb. 21, 2008) of the ...
... N.C., Feb. 20 Addrenex,Pharmaceuticals has reached its ... a new drug application (NDA) for its first ... Food and Drug,Administration, Addrenex and its licensing partner ... first half of 2009., Addrenex has moved ...
... SGI Altix, Altix XE Cluster and SGI InfiniteStorage ... Environment for All Stages of Research, SUNNYVALE, ... Annual Lorne Genome Conference -- To create an ... bioinformatics,research, the Malaysia Genomics Institute (MGI) selected SGI ...
Cached Biology Technology:Genetic pathway critical to disease, aging found 2Genetic pathway critical to disease, aging found 3Addrenex Pharmaceuticals Reaches Milestone with Filing of NDA for First Product, CloniBID, to Treat Hypertension 2Malaysia Genome Institute Advances Bioinformatics Research Using SGI Technology 2Malaysia Genome Institute Advances Bioinformatics Research Using SGI Technology 3Malaysia Genome Institute Advances Bioinformatics Research Using SGI Technology 4
... commonly used technique for studying protein function ... on SDS-PAGE and transferred to a membrane ... are probed with specific antibodies. Unlike nucleic ... Southern and Northern blots, it has been ...
... System, Basic Package Superior Protein Detection ... The ProXPRESS 2D Proteomic Imaging System is ... both proteomic and general life science research ... the use of all dyes in the ...
... our Regulatory Edition of Molecular Imaging (MI) ... for life science research and drug discovery ... with U.S. Food and Drug Administrations Code ... Electronic Records; Electronic Signatures [21 CFR Part ...
... OPA1-01009, OPEP-01009 is a 16 amino acid (amino acids 3-18) ... (DFF). The sequence of this peptide is (amino to ... S - V - K - L - R - ... R - K(18). This peptide may be used ...
Biology Products: