Navigation Links
St. Jude finds factors that accelerate resistance to targeted therapy in lymphoblastic leukemia
Date:8/29/2007

Results of a study by investigators at St. Jude Childrens Research Hospital provide strong evidence for why the targeted therapy drug, imatinib, or Gleevec, which has revolutionized the treatment of chronic myelogenous leukemia, (CML) is often unable to prevent relapse of a particularly aggressive form of acute lymphoblastic leukemia (ALL). Targeted therapy drugs are designed to block the activity of a specific molecule, a strategy aimed at making treatments more effective and less toxic.

The findings may shed new light on why a small percentage of children with ALL do not benefit from treatment, while more than 90 percent of children treated with the latest therapies survive. The discovery could also help researchers better understand both the origins of this form of aggressive ALL as well as why it becomes resistant to imatinib; and this knowledge may lead to more effective treatments for patients who are not helped by current therapies.

CML and an aggressive form of ALL share the same critical mutationthe Philadelphia chromosome (Ph). Cells that have this mutation (Ph+ cells) produce a rogue growth-promoting enzyme called BCR-ABL. Now, work by a team headed by Charles J. Sherr, M.D., Ph.D., a Howard Hughes Medical Institute investigator and co-chair of the St. Jude Department of Genetics and Tumor Cell Biology, has shown that these two forms of leukemia part company in a crucial respect.

Many Ph+ ALL cells lack a tumor-suppressor gene called Arf, which is normally present in CML cells at the time the disease is first diagnosed, said Sherr. Stripped of the anti-tumor effects of Arf and nurtured by growth factors produced in the bone marrow, these ALL cells become less responsive to imatinib and more difficult to eliminate. Sherr reasons that the cells survival advantage increases their opportunity to develop mutations in the BCR-ABL protein, which prompt imatinib resistance.

A report on these results appears in the Septe
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-495-3061
St. Jude Children's Research Hospital
Source:Eurekalert

1

GOOD

Page: 1 2

Related biology news :

1. Current human embryonic stem cell lines contaminated UCSD/Salk team finds
2. Another Look Finds Promising Proteomics Test is Not Biologically Plausible
3. Study finds more than one-third of human genome regulated by RNA
4. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
5. Same mutation aided evolution in many fish species, Stanford study finds
6. NC State scientist finds soft tissue in T. rex bones
7. New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
8. Genrate: a generative model that finds and scores new genes and exons in genomic microarray data
9. Genetically modified rice in China benefits farmers health, study finds
10. Survey finds silver contamination in North Pacific waters
11. Anti cancer virotherapy well tolerated in first human administration, research finds

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/6/2009)...ry this month of the publication of On the Origin ...ciences (AIBS) is publishing open access two peer-...toric insights into evolution. , The two articles...ia, Berkeley, and James T. Costa of Western Caroli...Charles Darwin," appeared in the October issue of ...
(Date:11/5/2009)...ale University have developed synthetic molecules ... HIV and HIV-infected cells, as well as to prostat...n the Journal of the American Chemical Society , ...se diseases. , The molecules called "antibody-...tibody-recruiting molecule targeting prostate canc...
(Date:11/4/2009)... Childhood obesity in the United States is reachin...of advertising on daytime and prime time televisio...estions about the role television plays in obesity...ournal of Nutrition Education and Behavior examin... a large contributor to the problem. , Researche...
Breaking Biology News(10 mins):New synthetic molecules trigger immune response to HIV and prostate cancer 2TV bombards children with commercials for high-fat and high-sugar foods 2TV bombards children with commercials for high-fat and high-sugar foods 3West Wireless Health Institute Teams with Corventis for its First Multicenter Randomized Clinical Trial 4638 1West Wireless Health Institute Teams with Corventis for its First Multicenter Randomized Clinical Trial 4638 2West Wireless Health Institute Teams with Corventis for its First Multicenter Randomized Clinical Trial 4638 3West Wireless Health Institute Teams with Corventis for its First Multicenter Randomized Clinical Trial 4638 4Confectionery Industry Forecast Is Sweet 3A Globally Inspired Flavors Eco Friendly and Health Minded Trends Lead New Product Innovations 49864 1Confectionery Industry Forecast Is Sweet 3A Globally Inspired Flavors Eco Friendly and Health Minded Trends Lead New Product Innovations 49864 2Confectionery Industry Forecast Is Sweet 3A Globally Inspired Flavors Eco Friendly and Health Minded Trends Lead New Product Innovations 49864 3Confectionery Industry Forecast Is Sweet 3A Globally Inspired Flavors Eco Friendly and Health Minded Trends Lead New Product Innovations 49864 4Confectionery Industry Forecast Is Sweet 3A Globally Inspired Flavors Eco Friendly and Health Minded Trends Lead New Product Innovations 49864 5Confectionery Industry Forecast Is Sweet 3A Globally Inspired Flavors Eco Friendly and Health Minded Trends Lead New Product Innovations 49864 6Hundreds of Fans and Entertainment Tonight Canada Greet Dr Siegals COOKIE DIET 28R 29 Creator Sanford Siegal D O M D at Book Signing Event in Mo 49861 1Hundreds of Fans and Entertainment Tonight Canada Greet Dr Siegals COOKIE DIET 28R 29 Creator Sanford Siegal D O M D at Book Signing Event in Mo 49861 2Hundreds of Fans and Entertainment Tonight Canada Greet Dr Siegals COOKIE DIET 28R 29 Creator Sanford Siegal D O M D at Book Signing Event in Mo 49861 3
...idies of cellulosic ethanol production and use hav...o an international group of scientists which inclu...d Oklahoma State University. , The 23-member gro...e-based policy to address this global issue for th...e, OU botany professor, and Michael Palmer, OSU bo...
...stern Reserve University School of Medicine has be...n The National Children,s Study, the National Inst...raction of genes and the environment on children,s...amed Case Western Reserve University School of Med...which would recruit study volunteers from a total ...
...ionary biologists are still debating this question...l PLoS ONE, supports the view that the first ega...ands of years before the French Revolution, Marx, ... intense power struggle and their origin had drama...ing in groups, including hyenas, meerkats, and dol...
Other Biology News:Oklahoma researchers support biodiversity in biofuels production 2NIH selects Case Western Reserve University to participate in National Children's Study 2Egalitarian revolution in the Pleistocene? 2Egalitarian revolution in the Pleistocene? 3Egalitarian revolution in the Pleistocene? 4
(Date:11/5/2009).... 5 WaferGen Biosystems,...per of state-of-the-art genetic analysis systems, ...joined the company,s Scientific Advisory Board. H...cializing novel molecular diagnostics for cancer d...pment of computational biology systems for several...
(Date:11/5/2009)...Drug safety specialty firm BioSoteria announced th... earned the Certified Professional in Learning and...rican Society for Training and Development (ASTD) ...e than fifteen years of medical communications and...e for the development of the company,s online phar...
(Date:11/4/2009)...This webinar, which will be presented on November ...ous flow chemistry processing, will deal with the ...various meso and micro scale flow chemistry equipm...s has been recognized with several prestigious pri...etrahedron Prize. , Colum...
(Date:11/4/2009).... 4 Star Scientific, I...mpany plans to introduce the CigRx(TM) nutraceutic... Pharmaceuticals, for worldwide marketing and sale...asdaq: VTIV). inVentiv Health offers a complete r...e of the product lifecycle, in a range of healthca...
Breaking Biology Technology:WaferGen Names Christopher Sears, Ph.D., Architect of High-Value Molecular Diagnostics and Computational Biology Platforms, to Company's Scientific Advisory Board 2WaferGen Names Christopher Sears, Ph.D., Architect of High-Value Molecular Diagnostics and Computational Biology Platforms, to Company's Scientific Advisory Board 3WaferGen Names Christopher Sears, Ph.D., Architect of High-Value Molecular Diagnostics and Computational Biology Platforms, to Company's Scientific Advisory Board 4BioSoteria eLearning Executive Michelle Nolin Flewell Earns Certification 2BioSoteria eLearning Executive Michelle Nolin Flewell Earns Certification 3BioSoteria eLearning Executive Michelle Nolin Flewell Earns Certification 4Professor Steven Ley of University of Cambridge will Present Free Webinar, 'Application of the ReactIR Flow Cell to Continuous Processing Technology' 2Professor Steven Ley of University of Cambridge will Present Free Webinar, 'Application of the ReactIR Flow Cell to Continuous Processing Technology' 3Star Scientific Plans Worldwide Marketing and Sales of CigRx(TM) Nutraceutical in Partnership with inVentiv Health 2Star Scientific Plans Worldwide Marketing and Sales of CigRx(TM) Nutraceutical in Partnership with inVentiv Health 3Star Scientific Plans Worldwide Marketing and Sales of CigRx(TM) Nutraceutical in Partnership with inVentiv Health 4
...adison, Wis. - During in the Battle of Britain in...e outnumbered pilots who defended the skies agains... human conflict was so much owed by so many to so ...uly 19 delivery of 1,400 used syringes to the Capi... have said, "Never in the field of politics were s...
...ison, Wis. -- Spanning fewer than a thousand atom...ave become so miniscule they defy most efforts to ...rs have demonstrated a way to image th0se vanishin...,In a study published in the Aug. 1 issue of Appl...ofessor of electrical and computer engineering, an...
...WAUKEE - Merge Technologies, Inc. , a developer ...nagement software and services, announced its seco...rowth and losses. , ,Although quarterly revenue wa...ook a loss of slightly under $12 million, or $0.62... costs after acquiring Cedara Software, Inc. , a ...
Other Biology Technology:Delivery of needles in the Capitol missed the point about stem-cell research 2Delivery of needles in the Capitol missed the point about stem-cell research 3Engineers chart semiconductors on the scale of atoms 2Engineers chart semiconductors on the scale of atoms 3Engineers chart semiconductors on the scale of atoms 4Cedara acquisition costs hit Merge Technologies numbers 2
...roFlex platform provides excellent performance, re...ormat applications, including washing of ELISAs, c...ration-to-waste, such as for PCR clean-up. The pla...w standards for plate washers, with options includ...
...and Accurate Results Laser Capture Microdissectio...ensitivity and accuracy of molecular assays by sta...ulti-cellular structures isolated from whole tissu...rodissection-developed in 1996 at the National Ins...
Mouse Anti-ZFHX4 Polyclonal Antibody, Unconjugated from Abnova Corporation
...ecificity and signaling of the members of the GPCR...licing--which has important implications for drug ... classical expression profiling and at the same ti...s of the gene that are expressed in the samples un...
Biology Products: