Navigation Links
St. Jude finds factors that accelerate resistance to targeted therapy in lymphoblastic leukemia
Date:8/29/2007

Results of a study by investigators at St. Jude Childrens Research Hospital provide strong evidence for why the targeted therapy drug, imatinib, or Gleevec, which has revolutionized the treatment of chronic myelogenous leukemia, (CML) is often unable to prevent relapse of a particularly aggressive form of acute lymphoblastic leukemia (ALL). Targeted therapy drugs are designed to block the activity of a specific molecule, a strategy aimed at making treatments more effective and less toxic.

The findings may shed new light on why a small percentage of children with ALL do not benefit from treatment, while more than 90 percent of children treated with the latest therapies survive. The discovery could also help researchers better understand both the origins of this form of aggressive ALL as well as why it becomes resistant to imatinib; and this knowledge may lead to more effective treatments for patients who are not helped by current therapies.

CML and an aggressive form of ALL share the same critical mutationthe Philadelphia chromosome (Ph). Cells that have this mutation (Ph+ cells) produce a rogue growth-promoting enzyme called BCR-ABL. Now, work by a team headed by Charles J. Sherr, M.D., Ph.D., a Howard Hughes Medical Institute investigator and co-chair of the St. Jude Department of Genetics and Tumor Cell Biology, has shown that these two forms of leukemia part company in a crucial respect.

Many Ph+ ALL cells lack a tumor-suppressor gene called Arf, which is normally present in CML cells at the time the disease is first diagnosed, said Sherr. Stripped of the anti-tumor effects of Arf and nurtured by growth factors produced in the bone marrow, these ALL cells become less responsive to imatinib and more difficult to eliminate. Sherr reasons that the cells survival advantage increases their opportunity to develop mutations in the BCR-ABL protein, which prompt imatinib resistance.

A report on these results appears in the Septe
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-495-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. Current human embryonic stem cell lines contaminated UCSD/Salk team finds
2. Another Look Finds Promising Proteomics Test is Not Biologically Plausible
3. Study finds more than one-third of human genome regulated by RNA
4. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
5. Same mutation aided evolution in many fish species, Stanford study finds
6. NC State scientist finds soft tissue in T. rex bones
7. New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
8. Genrate: a generative model that finds and scores new genes and exons in genomic microarray data
9. Genetically modified rice in China benefits farmers health, study finds
10. Survey finds silver contamination in North Pacific waters
11. Anti cancer virotherapy well tolerated in first human administration, research finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2013)... 18, 2013) Research presented today at Digestive Disease ... with findings about the impact of coffee on autoimmune ... While coffee consumption recently has been associated with reduced ... a few more cups of java each month also ... disease. Researchers at the Mayo Clinic, Rochester, MN, linked ...
(Date:5/17/2013)... day, insects provide the white noise of the South, but ... year, the Southern air hangs heavy from the humidity and ... more than 140 species of frogs, toads and salamanders, is ... the ponds and swamps are the auditorium for their symphonic ... and Monitoring Initiative, or ARMI, have front-row seats. ...
(Date:5/17/2013)... 2013, Shenzhen, China---- Why Tibetan antelope can live ... In a collaborative research published in Nature ... other institutes provide evidence that some genetic factors ... harsh highland environments. The data in this work ... mechanisms and the biology of other ruminant species. ...
Breaking Biology News(10 mins):Coffee consumption associated with reduced risk of autoimmune liver disease 2Front-row seats to climate change 2Front-row seats to climate change 3Front-row seats to climate change 4The genome sequence of Tibetan antelope sheds new light on high-altitude adaptation 2
... pieces of DNA in 100 small fish have opened ... technologies, researchers now know many of the genomic regions ... water in several independently evolved populations. The discovery ... National Science Foundation and National Institutes of Health -- ...
... HOUSTON, Feb. 25, 2010 Just weeks into his ... chair of the University of Houston,s new department of ... He was selected and recently inducted into ... Association for the Advancement of Science (AAAS) and the ...
... a paradox that,s puzzled scientists for a half-century. ... depends on those species responding differently to the availability ... species draw a blank? Competitors like black gums ... shaded understories of eastern U.S. forests, yet species-level data ...
Cached Biology News:Stickleback genomes shining bright light on evolution 2Stickleback genomes shining bright light on evolution 3New biomedical engineering chair earns high honors 2New biomedical engineering chair earns high honors 3Forest tree species diversity depends on individual variation 2Forest tree species diversity depends on individual variation 3
(Date:5/19/2013)... The JM Internet Group (web: jm-seo.org), ... proudly announced that the company's YouTube channel on ... views on YouTube. The company uses YouTube as a ... and training for small businesses with much success. , ... tips helpful for their SEO strategies", explained Jason McDonald, ...
(Date:5/17/2013)... transplant rejection occurs when the transplant recipient,s immune system ... it. It was previously thought that T cells, the ... by molecules known as chemokines in order to migrate ... Journal of Clinical Investigation , Fadi Lakkis and ... demonstrate that chemokine stimulation of T cells is not ...
(Date:5/17/2013)... TRIANGLE PARK, N.C., USA (PRWEB) May 17, 2013 ...     Green Globes Certified for sustainability , ... and insect pressures , Syngenta ... opening celebration today at the company’s RTP Innovation Center. ... Lab allows company researchers to simulate any agricultural climate ...
(Date:5/17/2013)... May 17, 2013 /PRNewswire-iReach/ -- Aridis is pleased ... with Switzerland -based Kenta Biotech ... monoclonal antibody (mAb) products, and technologies. This asset ... for treatment of infections by common pathogens including ... , Pseudomonas aeruginosa , Acinetobacter baumannii ...
Breaking Biology Technology:YouTube Channel on SEO Tips Surpasses 175,000 Views, Announces JM Internet Group 2Syngenta Opens Unique $72 Million Advanced Crop Lab 2Syngenta Opens Unique $72 Million Advanced Crop Lab 3Aridis Pharmaceuticals Announces Acquisition of Monoclonal Antibody Products and Technologies From Kenta Biotech 2Aridis Pharmaceuticals Announces Acquisition of Monoclonal Antibody Products and Technologies From Kenta Biotech 3
... 11 Friendly LRL Holdings LLC ("FLH") today announced that ... of the outstanding shares of common stock of Startech Environmental ... offer was scheduled to expire at 11:59 pm, New York ... previously tendered pursuant to the tender offer and not withdrawn ...
... PARIS, September 11 Novexel, a specialty pharmaceutical,company ... antibiotics,designed to overcome the significant global problem of ... subject of 16 posters and one slide,presentation at ... on,Antimicrobial Agents and Chemotherapy (ICAAC). The ICAAC meeting, ...
... 10 Bioheart, Inc., (OTC Bulletin Board: BHRT) a company ... diagnose and treat heart failure and other cardiovascular diseases announced ... development has been invited to participate in the 2009 World ... , Ms. Comella will speak on the concurrent ...
Cached Biology Technology:Friendly LRL Holdings Terminates Offer To Acquire Startech Environmental Corporation 2Friendly LRL Holdings Terminates Offer To Acquire Startech Environmental Corporation 3Novexel Presents 16 Posters and one Slide Presentation at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Meeting in San Francisco 2Novexel Presents 16 Posters and one Slide Presentation at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Meeting in San Francisco 3Novexel Presents 16 Posters and one Slide Presentation at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Meeting in San Francisco 4Novexel Presents 16 Posters and one Slide Presentation at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Meeting in San Francisco 5Bioheart Inc. to Participate in the 2009 World Stem Cell Summit on September 23rd 2Bioheart Inc. to Participate in the 2009 World Stem Cell Summit on September 23rd 3
... product contains 5 ml of DETACHaBEAD ... from Dynabeads CD19 (Pan B). ... (Pan B) and released with DETACHaBEAD ... Cells are suitable for applications such ...
This Malachite Green Phosphate Detection Kit...
5-bromo-4-chloro-3-indolyl b -D-galactopyranoside (X-Gal)...
...
Biology Products: