Navigation Links
St. Jude Children's Research Hospital announces issuance of US patent for cancer therapy
Date:3/19/2013

The United States Patent and Trademark Office today awarded St. Jude Children's Research Hospital U.S. patent number 8,399,645 for St. Jude's invention of compositions for genetically modifying human immune cells so they can destroy some of the most common forms of cancer in children and adults.

"This groundbreaking invention enables human immune cells to recognize and attack certain cells that cause leukemia and lymphoma, cancers of the blood and lymphatic tissue," said James R. Downing, M.D., St. Jude scientific director.

The patented technology represents a potentially potent new therapeutic weapon against such diseases as B-cell acute lymphoblastic leukemia (ALL), B-cell chronic lymphocytic leukemia (CLL) and B-cell non-Hodgkin lymphoma (NHL). Each year approximately 71,650 people in the United States are diagnosed with these diseases.

The invention involves genetically modifying human immune cells to enable them to manufacture a large protein molecule called a "chimeric antigen receptor" (CAR). The protein molecule is "chimeric" in that it is made from parts that do not exist together in the same molecule in nature. It is a "receptor" because a portion of it extends outside the surface of the immune cell and can receive signals from external "antigens." An antigen is a substance capable of stimulating an immune response in the human body. The CAR invented by St. Jude fits and latches onto "CD19" antigens prevalent on the B cells that cause ALL, CLL and NHL. It then stimulates the human immune cell to attack and kill the B cells.

"This exciting invention provides a new and promising treatment option for children and adults with these life-threatening diseases and sets the stage for treating other forms of cancer with cellular immunotherapy," Downing said.

In view of the landmark nature of the patent and the extraordinary potential of the technology for widespread use, St. Jude will make the technology availa
'/>"/>

Contact: Summer Freeman
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Research reveals first evidence of hunting by prehistoric Ohioans
3. Diabetes Research Institute develops oxygen-generating biomaterial
4. APS issues new policy requiring identification of sex or gender in reporting scientific research
5. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
6. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
7. U of Alberta researcher steps closer to understand autoimmune diseases
8. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
9. A project to research biological and chemical aspects of microalgae to fuel approach
10. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
11. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... Temple University School of Medicine announced today that ... initiative funded by the Bill & Melinda Gates ... Obstetrics, Gynecology and Reproductive Sciences; and Vice Chair ... School of Medicine will pursue an innovative global ... Biomarkers to Assess Fetal Neurodevelopment.", Grand Challenges Explorations ...
(Date:11/4/2014)... majority of Madagascar,s 101 species of lemurs are threatened ... the rainforests they call home. A new study by ... have on rainforest tree populations, which raises concerns about ... region,s rich biodiversity. , A large proportion of trees ... Lemurs in turn disperse the seeds of their fruit ...
(Date:11/3/2014)... 2014  NeuroSigma ® , Inc. (NeuroSigma), a ... focused on commercialization of its non-invasive ... of neurological and neuropsychiatric disorders, announced today that ... a Notice of Allowance for Mexican Patent Application ... NeuroSigma and the Regents of the University of ...
Breaking Biology News(10 mins):Temple University School of Medicine receives Grand Challenges Explorations grant 2Gardeners of Madagascar rainforest at risk 2Gardeners of Madagascar rainforest at risk 3NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 2NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 3
... called macrophages consume virus-infected cells to stop the spread ... Washington University School of Medicine in St. Louis have ... themselves. Boosting this mechanism may be a way to ... that a specific protein produced in the course of ...
... A wilting, water-starved houseplant and flood-covered crops have ... and researchers on two continents, potentially could open ... human health. , The research, which appeared online ... the journal Nature, involved a tandem of basic-science ...
... may help elucidate mechanisms of wake-sleep transitions and ... Pennsylvania School of Medicine have demonstrated that star-shaped ... directly involved in regulating communication between neurons. A ... modulate the level of a signaling molecule called ...
Cached Biology News:Shorter colds, milder flu may follow from newly revealed immune mechanism 2Shorter colds, milder flu may follow from newly revealed immune mechanism 3Membrane research opens window to benefits for plants, humans 2Membrane research opens window to benefits for plants, humans 3Penn study finds direct role for glial cells in brain cross-talk 2
(Date:11/26/2014)... PHILADELPHIA , Nov. 26, 2014 Space ... Human exploration of space requires astronauts to maintain consistently ... and success, and prevent potential errors and accidents. Despite ... is known about how cognition is affected by prolonged ... Now, Penn Medicine researchers are poised to ...
(Date:11/26/2014)... November 26, 2014 PMG Research, Inc. ... PMG Research is a network of sites that provide clinical ... over 2 million patient lives through its partnerships with large ... of 11 hub site locations in the Southeastern United States ... term of the board will be held by: ...
(Date:11/26/2014)... Continuing its award-winning streak, Nerium International, the ... Awards for outstanding creative achievement by its marketing and ... the organization’s top honor, in the Branding category for ... April of this year. The event showcased top speakers ... was awarded a Gold MarCom Award in the Special ...
(Date:11/26/2014)... SoundConnect , an award winning unified communications ... Darren Suders has joined the team as Director of ... partner program through innovative offerings, consistent partner ... brings more than 10-years of channel telecommunication experience to ... from policy development, to partner education and to expansion. ...
Breaking Biology Technology:Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 2Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 3Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 4PMG Research Names Medical Advisory Board 2PMG Research Names Medical Advisory Board 3Nerium International™ Wins One Platinum, Two Gold MarCom Awards 2SoundConnect Appoints Director of Channel Development & Sales 2
... SRI International has been awarded two National Cancer Institute ... provide SRI up to $11.7 million for toxicology studies ... studies that will be carried out through NCI,s Developmental ... SRI,s preclinical studies for the NCI, one of the ...
... 5, 2011 BioCrossroads today announced the receipt of ... The grant will fund a range of charitable, educational ... build upon Indiana,s signature strengths in the life sciences. ... in early 2012, we recognize that Lilly Endowment,s significant ...
... Elsevier, a world-leading provider of scientific, technical ... of Sydney, Australia,s leading higher education and research university, ... Hackathon . From Saturday, September 24 ... improve delivery of scientific, medical and technical content using ...
Cached Biology Technology:SRI International Awarded Two National Cancer Institute Preclinical Development Service Contracts 2SRI International Awarded Two National Cancer Institute Preclinical Development Service Contracts 3Two-year $2.8 million Grant from Lilly Endowment Fuels BioCrossroads' Charitable, Educational and Scientific Mission 2Two-year $2.8 million Grant from Lilly Endowment Fuels BioCrossroads' Charitable, Educational and Scientific Mission 3Elsevier and the University of Sydney Announce Prize Winners of 24-Hour Hackathon 2Elsevier and the University of Sydney Announce Prize Winners of 24-Hour Hackathon 3Elsevier and the University of Sydney Announce Prize Winners of 24-Hour Hackathon 4Elsevier and the University of Sydney Announce Prize Winners of 24-Hour Hackathon 5
...
Immunogen: Synthetic peptide (aa sequence is considered to be commercially sensitive) Storage: -20 C, Avoid Freeze/Thaw Cycles...
TRIzol Reagents are ready-to-use monophasic solutions of phenol and guanidine isothiocyanate suitable for isolating total RNA DNA and proteins (16)....
...
Biology Products: