Navigation Links
St. Jude Children's Research Hospital announces issuance of US patent for cancer therapy
Date:3/19/2013

The United States Patent and Trademark Office today awarded St. Jude Children's Research Hospital U.S. patent number 8,399,645 for St. Jude's invention of compositions for genetically modifying human immune cells so they can destroy some of the most common forms of cancer in children and adults.

"This groundbreaking invention enables human immune cells to recognize and attack certain cells that cause leukemia and lymphoma, cancers of the blood and lymphatic tissue," said James R. Downing, M.D., St. Jude scientific director.

The patented technology represents a potentially potent new therapeutic weapon against such diseases as B-cell acute lymphoblastic leukemia (ALL), B-cell chronic lymphocytic leukemia (CLL) and B-cell non-Hodgkin lymphoma (NHL). Each year approximately 71,650 people in the United States are diagnosed with these diseases.

The invention involves genetically modifying human immune cells to enable them to manufacture a large protein molecule called a "chimeric antigen receptor" (CAR). The protein molecule is "chimeric" in that it is made from parts that do not exist together in the same molecule in nature. It is a "receptor" because a portion of it extends outside the surface of the immune cell and can receive signals from external "antigens." An antigen is a substance capable of stimulating an immune response in the human body. The CAR invented by St. Jude fits and latches onto "CD19" antigens prevalent on the B cells that cause ALL, CLL and NHL. It then stimulates the human immune cell to attack and kill the B cells.

"This exciting invention provides a new and promising treatment option for children and adults with these life-threatening diseases and sets the stage for treating other forms of cancer with cellular immunotherapy," Downing said.

In view of the landmark nature of the patent and the extraordinary potential of the technology for widespread use, St. Jude will make the technology available for license.


'/>"/>

Contact: Summer Freeman
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Research reveals first evidence of hunting by prehistoric Ohioans
3. Diabetes Research Institute develops oxygen-generating biomaterial
4. APS issues new policy requiring identification of sex or gender in reporting scientific research
5. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
6. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
7. U of Alberta researcher steps closer to understand autoimmune diseases
8. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
9. A project to research biological and chemical aspects of microalgae to fuel approach
10. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
11. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... , May 3, 2016  Neurotechnology, a provider ... MegaMatcher Automated Biometric Identification System (ABIS) , ... multi-biometric projects. MegaMatcher ABIS can process multiple complex ... any combination of fingerprint, face or iris biometrics. ... SDK and MegaMatcher Accelerator , which ...
(Date:4/28/2016)... SAN FRANCISCO and BANGALORE, India ... part of EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... service provider, today announced a global partnership that ... convenient way to use mobile banking and payment services. ... Mobility is a key innovation area for financial services, but ...
(Date:4/28/2016)... -- First quarter 2016:   , Revenues ... first quarter of 2015 The gross margin was 49% ... and the operating margin was 40% (-13) Earnings per ... from operations was SEK 249.9 M (21.2) , Outlook ... 7,000-8,500 M. The operating margin for 2016 is estimated ...
Breaking Biology News(10 mins):
(Date:5/6/2016)... May 6, 2016 Recent studies show that ... prescription pain medication when treating certain types of pain. ... therapy, doctors can go right to the source instead ... an educational organization, provides physician training about the benefits ... feature to find physicians across the United ...
(Date:5/6/2016)... (PRWEB) , ... May 06, 2016 , ... ... their most recent release, Clinical Studio Version 4.1, greatly improves performance of the ... oncology, where protocols often generate tremendous volumes of data to be collected on ...
(Date:5/6/2016)... ... May 06, 2016 , ... This June 3-6, SonoDepot ... an exclusive sales and service provider of the ALPINION line, reps will educate attendees ... conference for healthcare technology management. The event draws more than 2,200 biomedical equipment technicians, ...
(Date:5/5/2016)... ... May 05, 2016 , ... ... agreement to acquire Algynomics, a research-stage pain diagnostics company. The Algynomics ... at increased risk for the development of chronic pain, which will allow targeted ...
Breaking Biology Technology: