Navigation Links
Spying on a cellular director in the cutting room
Date:3/21/2010

ANN ARBOR, Mich.---Like a film director cutting out extraneous footage to create a blockbuster, the cellular machine called the spliceosome snips out unwanted stretches of genetic material and joins the remaining pieces to fashion a template for protein production.

But more than box office revenues are at stake: if the spliceosome makes a careless cut, disease likely results.

Using a new approach to studying the spliceosome, a team led by University of Michigan chemistry and biophysics professor Nils Walter, collaborating closely with a team led by internationally recognized splicing experts John Abelson and Christine Guthrie of the University of California, San Francisco, spied on the splicing process in single molecules.

The research is scheduled to be published online March 21 in Nature Structural and Molecular Biology.

Since its Nobel Prize-winning discovery in 1977, gene splicing has been studied in a number of organisms, including yeast and human cells, using both genetic and biochemical approaches. While these methods can yield snapshots, they can't monitor the ongoing process. The new study, which utilizes a technique called fluorescence resonance energy transfer (FRET) and a sophisticated microscope that watches single molecules in action, allows researchers to observe in real time the contortions involved in spliceosome assembly and operation.

By molecular-scale standards, the spliceosome is a monster of a machine, made up of five RNA and 100 or more protein subunits that agilely assemble, step-by-step, into the giant complex when it's time to carry out its work.

True to the movie director analogy, the spliceosome not only wields the scissors, it's also "the brain that decides where to cut," Walter said. The "footage" it works on is the genetic material contained in RNA molecules.RNA carries coded instructions for producing the proteins our body needs for building and repairing tissues,
'/>"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Blocking cancer in its path: New cellular defect discovered
2. New microscopy technique offers close-up, real-time view of cellular phenomena
3. OHSU researchers discover cellular mechanism that protects against disease
4. Shifting cellular energy metabolism may help treat cardiovascular disease
5. Researchers identify a new gene involved in autophagy, the cellular recycling program
6. New edition of popular lab manual presents latest techniques for probing cellular dynamics
7. New discovery by Harvard scientists aims to correct cellular defects leading to diabetes
8. Looking for the heartbeat of cellular networks
9. Carnegie Mellon researchers to develop probes to study cellular GPS
10. Think what you eat: Studies point to cellular factors linking diet and behavior
11. The food-energy cellular connection revealed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... 2015 According to a new ... Assessment Type (Pen & Paper Based, Hosted, Biometrics), Service, ... Academic Research), Vertical and Region - Global Forecast to ... to grow from USD 2.4 Billion in 2015 to ... Growth Rate (CAGR) of 25.6% from 2015 to 2020. ...
(Date:8/26/2015)... , August 26, 2015 The ... and Five Factor), Application (Travel & Immigration, Government, Banking, ... Global Forecast to 2020", published by MarketsandMarkets, Multi-Factor Authentication ... 2020, growing at a CAGR of 17.7% between 2015 ... 82 F igures spread through 169 ...
(Date:8/25/2015)... LAKE CITY and BELLEVUE, Wash. ... global leader in advanced robotic systems, announced today it ... robotic unmanned ground vehicle (UGV), at the National Tactical ... City.  The Guardian S is the ... the culmination of years of research and in-field trials ...
Breaking Biology News(10 mins):Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 2Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 3Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 4Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 2Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 3Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 4Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 5Sarcos to Debut First-of-its-Kind Snake Robot 2Sarcos to Debut First-of-its-Kind Snake Robot 3
... and vegetables is a new, patented technology in which a ... "etch" information on produce, thereby eliminating the need for common ... a variety of fruits and vegetables and is being used ... been been approved in Asia, South Africa, Central and South ...
... of Illinois at Chicago have received $1 million from ... the relationship between "fat taxes" and food consumption, diet ... project was made available through the American Recovery and ... state tax rates associated with restaurants and with specific ...
... If a circadian rhythm is like an orchestra the united ... chemical may serve as the conductor, or at least as the ... ), the active ingredient in color safe bleach. Produced in all ... active and resting phases of living things, new research by USC ...
Cached Biology News:Laser etching safe alternative for labeling grapefruit 2UIC receives $1 million grant to study 'fat taxes,' diet, obesity 2Not just bleach: Hydrogen peroxide may tell time for living cells 2Not just bleach: Hydrogen peroxide may tell time for living cells 3
(Date:8/30/2015)... , August 31, 2015 ... einer Frau   für chirurgische   Behandlung     ... 7-90   werden für eine   verheerende   ... Frauen behandeln und die Anzahl ausgebildeter Chirurgen in Kenia ... Astellas gab heute bekannt, dass  Action on Fistula  seit ...
(Date:8/28/2015)... DUBLIN , Aug. 28, 2015 ... announced the addition of the "Global & USA ... offering. The highly awaited US Biosimilar market ... highly awaited filigrastim biologic, Zarxio. How will the global ... The author reveals that biosimilars could save the US ...
(Date:8/28/2015)... , August 28, 2015 According ... (Media, Sera, Cryogenic Storage Systems, Thawing Equipment, Alarms), by ... Medicine, Clinical Trials), End User - Global Forecast to ... expected to reach USD 3,731.03 Million by 2020 from ... of 11.65% between 2015 and 2020. ...
(Date:8/28/2015)... ... August 28, 2015 , ... Proove Biosciences , ... International Spine Intervention Society’ s 23rd Annual Scientific Meeting (ASM). The ... With a focus on evidence-based research and clinical application, the event gathered industry ...
Breaking Biology Technology:Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 2Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 3Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 4Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 5Global & USA BioSimilar Market Analysis Report 2015-2021 2Global & USA BioSimilar Market Analysis Report 2015-2021 3Biopreservation Market Worth 3,731.03 Million USD by 2020 2Biopreservation Market Worth 3,731.03 Million USD by 2020 3Biopreservation Market Worth 3,731.03 Million USD by 2020 4Biopreservation Market Worth 3,731.03 Million USD by 2020 5Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 2Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 3Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 4
... February 26 Arpida Ltd.,(SWX: ARPN) today reported that ... intravenous iclaprim in its first indication,complicated Skin and Skin ... weeks., Arpida has agreed with the U.S. Food ... rolling process. Using a ,rolling NDA, allows modules,within the ...
... Therapeutics,Inc. (Nasdaq: TPTX ) today announced that ... TorreyPines, will present at Susquehanna,Financial Group,s Second Annual ... on Tuesday, March 4th at 11:00 a.m., Eastern., ... be available live. You can,access the webcast at: ...
... BURLINGTON, Mass., Feb. 26 Hyaluron ... development,services, continued to expand its business in ... and staffing increasing greater than 60 percent ... HCM acquired,additional space at its Burlington MA ...
Cached Biology Technology:Arpida Provides Update on Progress of New Drug Application for Intravenous Iclaprim 2Arpida Provides Update on Progress of New Drug Application for Intravenous Iclaprim 3TorreyPines Therapeutics to Present at Susquehanna Financial Group's Second Annual SIGnificant Options in Healthcare Conference 2HCM Announces Substantial Growth in 2007 2
Perm/Wash Buffer 250 Tests...
Complete PCR kit. Includes: MasterAmp™ Taq DNA Polymerase, 10X PCR Buffer, MasterAmp™ 10X PCR Enhancer, dNTP Mix, 2.5 mM each, 25 mM MgCl2, Enzyme Dilution Buffer, Control Template and Prim...
Rabbit polyclonal to 3-Ethynylestradiol ( Abpromise for all tested applications). Antigen: Ethynylestradiol conjugated to BSA....
... GenBank Accession Number : ... (C-QSQENQDTRPKVKAKK), corresponding to amino acids ... Formulation: antiserum in 0.05% sodium ... Assurance: routinely evaluated by immunoblot ...
Biology Products: