Navigation Links
Spontaneous gene glitches linked to autism risk with older dads
Date:4/4/2012

ons in autism, those pinpointed were biologically related to each other and to genes previously implicated in autism.

The Eichler team turned up clues to how environmental factors might influence genetics. The high turnover in a male's sperm cells across the lifespan increases the chance for errors to occur in the genetic translation process. These can be passed-on to the offspring's DNA, even though they are not present in the father's DNA. This risk may worsen with aging. The researchers discovered a four-fold marked paternal bias in the origins of 51 spontaneous mutations in coding areas of genes that was positively correlated with increasing age of the father. So such spontaneous mutations could account for findings of an earlier study that found fathers of boys with autism were six times and of girls 17 times more likely to be in their 40's than their 20's.

"We now have a path forward to capture a great part of the genetic variability in autism even to the point of being able to predict how many mutations in coding regions of a gene would be needed to account for illness," said Thomas Lehner, Ph.D., chief of the NIMH Genomics Research Branch, which funded the Daly study and helped to create the Autism Sequencing Consortium. "These studies begin to tell a more comprehensive story about the molecular underpinnings of autism that integrates previously disparate pieces of evidence."


'/>"/>

Contact: Jules Asher
NIMHpress@nih.gov
301-443-4536
NIH/National Institute of Mental Health
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Surprising findings from studies of spontaneous brain activity
2. Management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis
3. Scripps research study shows infectious prions can arise spontaneously in normal brain tissue
4. Researchers show some cells in pancreas can spontaneously change into insulin-producing cells
5. Spontaneous assembly
6. Orangutans spontaneous whistling opens new chapter in study of evolution of speech
7. Scientists link genetic glitches to common childhood cancer
8. Autism risk gene linked to differences in brain structure
9. Exposure to antibiotics linked to severity of allergic asthma: UBC research
10. Environmental pollutant linked with overweight
11. Pancreatic hormone linked with severe heart disease in obese and diabetic patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... a rare, but deadly disease that exists as five ... the most lethal strains is the Sudan ebolavirus (SUDV). ... has caused widespread illness, even as recently as 2012. ... ACS Chemical Biology , researchers now report a possible ... SUDV. , John Dye, Sachdev Sidhu, Jonathan Lai and ...
(Date:8/27/2014)... Thousands of fishing traps are lost or abandoned each ... as derelict traps, which continue to catch fish, crabs, ... in losses to habitat, fisheries, and the watermen who ... to a newly published NOAA study. , The report, ... the first of its kind to examine the derelict ...
(Date:8/27/2014)... can be weaned later with no negative effects on ... at the University,s Roseworthy campus, published in the journal ... for pig producers. It allows improvements in piglet health ... usually start their oestrous cycles again during lactation, only ... says Ms Alice Weaver, PhD candidate with the School ...
Breaking Biology News(10 mins):Potential therapy for the Sudan strain of Ebola could help contain some future outbreaks 2NOAA's Marine Debris Program reports on the national issue of derelict fishing traps 2Piglet weaning age no bar to litter frequency 2
... This release is available in French . ... memories is essential to our daily existence and identity; enabling ... researchers at the Montreal Neurological Institute and Hospital (The Neuro), ... an image for the first time of a mechanism, specifically ...
... The mystery of giant sperm present in some living ... In one group of micro-crustaceans new evidence shows the ... Renate Matzke-Karasz, from Ludwig-Maximilians-Universitt Munich (Germany), has ... the London Natural History Museum,s collections. Their research has ...
... Scavia and his colleagues say this year,s Gulf of Mexico ... continuing a decades-long trend that threatens the health of a ... for a Gulf dead zone of between 7,450 and 8,456 ... Most likely, this summer,s Gulf dead zone will blanket about ...
Cached Biology News:Scientists capture the first image of memories being made 2Size did matter 2U-M researcher and colleagues predict large 2009 Gulf of Mexico 'dead zone' 2U-M researcher and colleagues predict large 2009 Gulf of Mexico 'dead zone' 3
(Date:8/28/2014)... executives from clinical trial marketing firm BBK Worldwide will lead ... Clinical Trials 2014 , to be held at the Hyatt ... Patient recruitment experts Bonnie A. Brescia , Matthew ... on the benefits of employing an effective patient engagement strategy, ... mobile apps – can be used to drive study participation ...
(Date:8/28/2014)... Exciting new work by a Florida State University ... that can take your temperature, emit white light, and ... the molecule looks like a butterfly. , Biwu Ma, ... Engineering in the FAMU-FSU College of Engineering, created the ... has continued to discover that his creation has many ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 PrimeSource ... construction materials, selected SoundConnect to support ... cloud based audio and web conferencing platform GlobalMeet ... support PrimeSource’s employees’ needs. SoundConnect delivers award ... , PrimeSource Building Products will be utilizing ...
(Date:8/27/2014)... Green & Grow Inc. (GGI) has raised ... secured Otter Capital as a significant new partner. Otter ... GGI’s Agriplier™ technology, building on recent compelling field trial ... first meeting, we have been impressed with Otter Capital’s ... Alan Sobba, President and CEO of GGI. “We look ...
Breaking Biology Technology:BBK Worldwide Leads Sessions at Key September Events 2Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2PrimeSource Chooses SoundConnect as Collaboration Provider 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3
... PARIS, September 11 Novexel, a specialty pharmaceutical,company ... antibiotics,designed to overcome the significant global problem of ... subject of 16 posters and one slide,presentation at ... on,Antimicrobial Agents and Chemotherapy (ICAAC). The ICAAC meeting, ...
... , SUNRISE, Fla., Sept. 10 Bioheart, Inc., ... devices and biologics that help monitor, diagnose and treat heart ... Vice President of R&D and Corporate development has been invited ... Baltimore, Maryland, this month. , , Ms. ...
... , HOUSTON, Sept. 10 ... with Beech Street Corporation, one of the nation,s largest preferred ... assist SpectraCell with the ever-increasing administrative needs that accompany healthcare ... , Beech Street addresses the various coverage obstacles ...
Cached Biology Technology:Novexel Presents 16 Posters and one Slide Presentation at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Meeting in San Francisco 2Novexel Presents 16 Posters and one Slide Presentation at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Meeting in San Francisco 3Novexel Presents 16 Posters and one Slide Presentation at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Meeting in San Francisco 4Novexel Presents 16 Posters and one Slide Presentation at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Meeting in San Francisco 5Bioheart Inc. to Participate in the 2009 World Stem Cell Summit on September 23rd 2Bioheart Inc. to Participate in the 2009 World Stem Cell Summit on September 23rd 3SpectraCell Contracts With Beech Street Corporation 2