Navigation Links
Spontaneous gene glitches linked to autism risk with older dads
Date:4/4/2012

ons in autism, those pinpointed were biologically related to each other and to genes previously implicated in autism.

The Eichler team turned up clues to how environmental factors might influence genetics. The high turnover in a male's sperm cells across the lifespan increases the chance for errors to occur in the genetic translation process. These can be passed-on to the offspring's DNA, even though they are not present in the father's DNA. This risk may worsen with aging. The researchers discovered a four-fold marked paternal bias in the origins of 51 spontaneous mutations in coding areas of genes that was positively correlated with increasing age of the father. So such spontaneous mutations could account for findings of an earlier study that found fathers of boys with autism were six times and of girls 17 times more likely to be in their 40's than their 20's.

"We now have a path forward to capture a great part of the genetic variability in autism even to the point of being able to predict how many mutations in coding regions of a gene would be needed to account for illness," said Thomas Lehner, Ph.D., chief of the NIMH Genomics Research Branch, which funded the Daly study and helped to create the Autism Sequencing Consortium. "These studies begin to tell a more comprehensive story about the molecular underpinnings of autism that integrates previously disparate pieces of evidence."


'/>"/>

Contact: Jules Asher
NIMHpress@nih.gov
301-443-4536
NIH/National Institute of Mental Health
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Surprising findings from studies of spontaneous brain activity
2. Management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis
3. Scripps research study shows infectious prions can arise spontaneously in normal brain tissue
4. Researchers show some cells in pancreas can spontaneously change into insulin-producing cells
5. Spontaneous assembly
6. Orangutans spontaneous whistling opens new chapter in study of evolution of speech
7. Scientists link genetic glitches to common childhood cancer
8. Autism risk gene linked to differences in brain structure
9. Exposure to antibiotics linked to severity of allergic asthma: UBC research
10. Environmental pollutant linked with overweight
11. Pancreatic hormone linked with severe heart disease in obese and diabetic patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... 31 de julho de 2015 A 10 ... ) será realizada pela BGI de 22-25 de outubro de ... A conferência está celebrando seu 10 o. ... ICG se tornou uma das reuniões mais influentes do ... científicos mais dinâmicos, entusiastas e prazerosos. ...
(Date:7/31/2015)... Conn. , Jul. 31, 2015 NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... that it has filed provisional patent 62/198989 for ... This invention highlights a method to advance crypto-currencies such ... by introducing a common, uniform way to manage all ...
(Date:7/27/2015)... LOS ANGELES , July 27, 2015 /PRNewswire/ ... providing evidence- and experience-based clinical improvement solutions, today ... coordination solution is now available on Android smartphones ... at inpatient and post-care organizations can use ZynxCarebook ... the same patient,s condition, streamline care transitions to ...
Breaking Biology News(10 mins):A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3NXT-ID Patents Electronic Crypto-Currency Management Technology 2NXT-ID Patents Electronic Crypto-Currency Management Technology 3NXT-ID Patents Electronic Crypto-Currency Management Technology 4Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3
... simpler technique for testing public drinking water samples for ... reduce the amount of time required to conduct the ... Protection Agency (EPA) has approved use of the new ... Kahn, director of the Georgia Tech Research Institutes (GTRI) ...
... PITTSBURGH, Aug. 28 Gamma globulin, a type of ... routinely given to health care workers and international travelers ... effective treatment for pinkeye with little apparent toxicity, according ... Pittsburgh School of Medicine. The results of the study, ...
... September 2007 issue of the Journal of Lipid ... Renal transplant recipients genetic makeup does ... anti-inflammatory compound discovered Thematic Review: Understanding how obese fat ... recipients genetic makeup does not negatively impact fluvastatin use ...
Cached Biology News:Safe water: simpler method for analyzing radium in water samples cuts testing time 2Safe water: simpler method for analyzing radium in water samples cuts testing time 3Gamma globulin effective in treating eye infections caused by adenoviruses 2Story ideas from the Journal of Lipid Research 2Story ideas from the Journal of Lipid Research 3Story ideas from the Journal of Lipid Research 4Story ideas from the Journal of Lipid Research 5
(Date:7/30/2015)... Denmark , July 30, 2015 ... biotechnology company that applies its innovative TransCon technology ... positive top-line results from a six-month Phase 2 ... once-weekly TransCon Growth Hormone in 53 treatment-naïve, pre-pubertal ... "We are extremely pleased with the top-line ...
(Date:7/30/2015)... NH (PRWEB) , ... July 30, 2015 , ... ... homogenizer for advanced fluid applications and designed for continuous operation up to 1500 ... and sterilization-in-place, ensuring safety, efficiency, and preventing toxic contamination. , The Pony™ NS2006L ...
(Date:7/29/2015)... July 29, 2015 US-Australian drug discovery company, ... confirmed it is committed to progressing its ground-breaking technology ... practicable and to ensure the Company delivers the best ... Iain Ross , said the Company currently had ... pre-clinical programs, discovery programs and academic partnerships and initiatives, ...
(Date:7/29/2015)... 29, 2015  AsureQuality and Ubiquitome have agreed ... applications in food and primary production sectors. The ... PCR device, the Freedom4. AsureQuality provides ... the supermarket shelf for producers, processors and Competent ... animal disease control and pest management and surveillance ...
Breaking Biology Technology:Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 5Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 6Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 7GEA Announces the Pony™ NS2006L… a Self-contained, High Pressure Lab Homogenizer for Product Development Ensuring Maximum Efficiency and Safety 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 3Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 4Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 5Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 6Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 7Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 8Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 9Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 10AsureQuality and Ubiquitome Partner on Applications for Mobile Molecular Food Safety Testing 2
... JERUSALEM, Sept. 21 Chiasma, Inc., a privately ... CEO, will present an overview of the Company at the ... York, New York, on Wednesday, September 22, 2010 at 11:00 ... clinical trial of the investigational new drug Octreolin™, an oral ...
... Spain, Sept. 20 Talecris Biotherapeutics GmbH announced ... Laurell,s Training Awards (eALTA). The annual awards, sponsored ... to young investigators whose research aims to enhance ... deficiency). AAT deficiency is a rare, genetic condition ...
... KERX ) today announced that Ron Bentsur, the ... UBS Global Life Sciences Conference, being held at the Grand ... scheduled to take place on Wednesday, September 22, 2010, at ... Bentsur,s presentation will be accessible from the Investor Information page ...
Cached Biology Technology:Chiasma to Present at the UBS Global Life Sciences Conference 2Chiasma to Present at the UBS Global Life Sciences Conference 3Talecris Biotherapeutics GmbH Awards Winners of the 7th Annual European ALTA Research Fellowship at 2010 ERS Meeting 2Talecris Biotherapeutics GmbH Awards Winners of the 7th Annual European ALTA Research Fellowship at 2010 ERS Meeting 3Talecris Biotherapeutics GmbH Awards Winners of the 7th Annual European ALTA Research Fellowship at 2010 ERS Meeting 4Talecris Biotherapeutics GmbH Awards Winners of the 7th Annual European ALTA Research Fellowship at 2010 ERS Meeting 5Keryx Biopharmaceuticals to Present at the UBS 2010 Global Life Sciences Conference 2
TUNEL Apoptosis Detection Kit...
homeo box D3, mRNA...
SNARE associated protein snapin, clone MGC:2717...
Human Serpin A8/AGT Affinity Purified Polyclonal Ab Keywords: Ang II, AngII, Hypertension, Salt Homeostasis, Pre-eclampsia...
Biology Products: