Navigation Links
Spontaneous fusion with macrophages empowers cancer cells to spread
Date:12/15/2013

Cancer cells that spontaneously fuse with macrophages, the immune system's healthy scavenger cells, play a key role in the metastasis, or spread of the cancer to other areas of the body, according to research to be presented Sunday, Dec. 15, at the American Society for Cell Biology annual meeting in New Orleans.

The researchers, Alain Silk, Ph.D., Melissa Wong, Ph.D., and colleagues at Oregon Health & Science University (OHSU) in Portland followed the work of German pathologist Otto Aichel, who suggested in 1911 that a cancer cell under attack by a white blood cell might spontaneously fuse with that cell to produce a hybrid cell with chromosomal abnormalities that could lead to cancer.

Although Aichel's theory was dismissed by his contemporaries, recent discoveries about the broader role of cell fusion in tissue homeostasis and regeneration have revived scientific interest in his ideas. Today there is strong evidence of fusion between cancer and normal cells in human cancer, but it has not been apparent whether cell fusion could provide cancer cells with a selective advantage that enhances cancer progression.

The OSHU researchers began by confirming that cells from various types of cancer could readily and spontaneously fuse with macrophages. By intensively studying the fusion-derived cancer cells, the researchers determined that these cells exhibited enhanced adhesive strength, formed tumors more rapidly than unfused cancer cells and flourished under conditions that dramatically inhibited growth of unfused cells.

"Overall, our findings demonstrate that spontaneous fusion of cancer cells with macrophages can profoundly and significantly impact the phenotype of tumorigenic cells, with implications for our basic understanding of cancer cell biology and the process of tumor evolution," the researchers said.

As cancer progresses, tumor cells acquire new capabilities, or phenotypes. They must grow in an uncontrolled manner, leave their site of origin and become resistant to anti-cancer drugs. Previous studies on the biology of cancer have revealed that cancer progression are determined by changes to the cancer genome, epigenetics, influences from the microenvironment, exosomes and the interplay with the immune system. The OSHU research implicates the fusion of cancer cells with macrophages as a new potentiator of cancer progression.


'/>"/>

Contact: Cathy Yarbrough
cyarbrough@ascb.org
858-243-1814

John Fleischman
jfleischman@ascb.org

American Society for Cell Biology
Source:Eurekalert


Related biology news :

1. Spontaneous gene glitches linked to autism risk with older dads
2. Spontaneous mutations are major cause of congenital heart disease
3. New release of Web-based resource resolves confusion over plant names
4. University of Tennessee, ORNL lead national team to study nuclear fusion reactors
5. Better blood transfusions for preterm babies
6. Olive oil component alleviates intestinal ischemia and reperfusion
7. First-ever therapeutic offers hope for improving blood transfusions
8. Salvianolate for treatment of cerebral ischemia-reperfusion injuries
9. Can Aβ worsen cognitive impairment following cerebral ischemia-reperfusion injury?
10. Practice Fusion Raises Additional $15M to Close Year of Exponential Platform Growth
11. Study finds depletion of alveolar macrophages linked to bacterial super-infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... -- Janice Kephart , former 9/11 Commission ... LLP (IdSP) , today issues the following statement: ... 6, 2017 Executive Order: Protecting the Nation ... instilled with greater confidence, enabling the reactivation of ... are suspended by until at least July 2017). ...
(Date:4/17/2017)... MELBOURNE, Florida , April 17, 2017 ... security technology company, announces the filing of its 2016 Annual Report ... Securities and Exchange Commission. ... Report on Form 10-K is available in the Investor Relations section ... well as on the SEC,s website at http://www.sec.gov . ...
(Date:4/11/2017)... , April 11, 2017 Crossmatch®, ... secure authentication solutions, today announced that it has ... Advanced Research Projects Activity (IARPA) to develop next-generation ... program. "Innovation has been a driving ... Thor program will allow us to innovate and ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... ... Disappearing forests and increased emissions are the main causes of the evolving air ... living in larger cities are affected by air pollution related diseases. , That is ... globally - decided to take action. , “I knew I had to take action ...
(Date:10/10/2017)... DIEGO, CALIF. (PRWEB) , ... October 10, 2017 , ... ... as part of its corporate rebranding initiative announced today. The bold new look ... its reach, as the company moves into a significant growth period. , It will ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO of ... Club. The event entitled “Stem Cells and Their Regenerative Powers,” was ... Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. Hanson, M.D., ...
(Date:10/10/2017)... ... 10, 2017 , ... USDM Life Sciences , the ... sciences and healthcare industries, announces a presentation by Subbu Viswanathan and Jennifer Jaye ... GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach to achieving ...
Breaking Biology Technology: