Navigation Links
Sperm may be harmed by exposure to BPA, study suggests

ANN ARBOR, Mich.---In one of the first human studies of its kind, researchers have found that urinary concentrations of the controversial chemical Bisphenol A, or BPA, may be related to decreased sperm quality and sperm concentration.

However, the researchers are quick to point out that these results are preliminary and more study is needed. Several studies have documented adverse effects of BPA on semen in rodents, but none are known to have reported similar relationships in humans.

BPA is a common chemical that's stirred much controversy in the media lately over its safety. Critics say that BPA mimics the body's own hormones and may lead to negative health effects. BPA is most commonly used to make plastics and epoxy resins used in food and beverage cans, and people are exposed primarily through diet, although other routes are possible. More than 6 billion pounds of BPA are produced annually.

The new study suggests that more research should focus on BPA and health effects in adults, says John Meeker, assistant professor of Environmental Health Sciences at the University of Michigan School of Public Health.

Meeker is the lead author on the study, along with Russ Hauser, the Frederick Lee Hisaw Professor of Reproductive Physiology at Harvard School of Public Health. Colleagues at Massachusetts General Hospital and the U.S. Centers for Disease Control and Prevention also contributed to the research.

"Much of the focus for BPA is on the exposures in utero or in early life, which is of course extremely important, but this suggests exposure may also be a concern for adults," Meeker said. "Research should focus on impacts of exposure throughout multiple life stages."

Meeker and Hauser recruited 190 men through a fertility clinic. All gave spot urine samples and sperm samples the same day. Subsequently, 78 of the men gave one or two additional urine samples a month apart. Researchers detected BPA in 89 percent of the urine samples.

Researchers measured sperm concentration, sperm motility, sperm shape and DNA damage in the sperm cell.

"We found that if we compare somebody in the top quartile of exposure with the lowest quartile of exposure, sperm concentration was on average about 23 percent lower in men with the highest BPA," Meeker said.

Results also suggested a 10 percent increase in sperm DNA damage.

The results are consistent with a previous study by Meeker and Hauser suggesting that certain hormones, specifically FSH (follicle-stimulating hormone) and Inhibin B, are elevated or decreased in relation to BPA, respectively, a pattern consistent with low sperm production and development.

Meeker stressed that further study is necessary due to the study's relatively small sample size and design.

"The study from which these data came is currently in progress," Hauser said. "With a larger sample size and enhanced study design, we will be able to more definitively investigate this preliminary association in the near future."


Contact: Laura Bailey
University of Michigan

Related biology news :

1. Yale researchers develop test to identify best sperm
2. UT Southwestern researchers use novel sperm stem-cell technique to produce genetically modified rats
3. Females shut down male-male sperm competition in leafcutter ants
4. Molecular study could push back angiosperm origins
5. MMS and NOAA scientists study prey of Gulf of Mexico sperm whales
6. ESHREs workshop on freezing of human sperm, eggs and embryos in Athens
7. Spread your sperm the smart way
8. The egg makes sure that sperm dont get too old
9. CSHL scientists discover how companion cells to sperm protect them from genetic damage
10. The more promiscuous the female, the speedier the sperm
11. Proteins in sperm unlock understanding of male infertility says new study
Post Your Comments:
(Date:10/29/2015)... --  MedNet Solutions , an innovative SaaS-based eClinical technology ... is pleased to announce that it has been selected ... of only three finalists for a 2015 Tekne ... category. The Tekne Awards honor Minnesota ... and leadership. iMedNet™ eClinical  technology ...
(Date:10/29/2015)... , Oct. 29, 2015  Rubicon Genomics, Inc., ... U.S. distribution of its DNA library preparation products, ... Rubicon,s new ThruPLEX Plasma-seq kit. ThruPLEX Plasma-seq has ... preparation of NGS libraries for liquid biopsies--the analysis ... and prognostic applications in cancer and other conditions. ...
(Date:10/29/2015)... 2015 Today, LifeBEAM , a ... 2XU, a global leader in technical performance sports ... with advanced bio-sensing technology. The hat will allow ... key biometrics to improve overall training performance. As ... will bring together the most advanced technology, extensive ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... DIEGO , Nov. 24, 2015 Halozyme Therapeutics, Inc. ... Healthcare Conference in New York on Wednesday, ... Helen Torley , president and CEO, will provide a corporate ... New York at 1:00 p.m. ET/10:00 a.m. PT ... and investor relations, will provide a corporate overview. --> ...
(Date:11/24/2015)... QUEBEC CITY , Nov. 24, 2015 /PRNewswire/ - ... the request of IIROC on behalf of the Toronto ... this news release there are no corporate developments that ... price. --> --> ... --> . --> Aeterna Zentaris ...
(Date:11/24/2015)... IN (PRWEB) , ... November 24, 2015 , ... The ... newest Special Interest Group (SIG), MultiGP, also known as Multirotor Grand Prix, to represent ... the last few years. Many AMA members have embraced this type of racing and ...
(Date:11/24/2015)... , Nov. 24, 2015 /PRNewswire/ - Aeterna ... announced today that the remaining 11,000 post-share consolidation ... Purchase Warrants (the "Series B Warrants") subject to ... exercised on November 23, 2015, which will result ... After giving effect to the issuance of such ...
Breaking Biology Technology: