Navigation Links
Speedy computation enables scientists to reconstruct an animal's development cell by cell
Date:7/20/2014

ed by the microscope, and the result is lineage information for every cell. "You know the path, you know where it is at a certain time point. You know it divided at a certain point, you know the daughter cells, you know what mother cell it came from," Keller says.

Finally, a human steps in to check the computer's work and fix any mistakes. A computer-generated "confidence score" for every cell at every time point guides the user to the small percentage of data most likely to require a human eye, making high overall accuracy possible without manual examination of each cell.

To test the power of the program, Keller's team collected images of the beginnings of the nervous system as it developed in an embryonic fruit fly. They used their method to trace the lineages of 295 neuroblasts (precursors of nerve cells) and discovered that it is possible to predict the future fate and function of many cells based on their early dynamic behavior.

Keller is eager to begin using the method to investigate a variety of questions about early development, and hopes that others will apply the approach to their own questions. To that end, the team took care to ensure that the technique can be used with a variety of data types. In addition to fruit flies, they successfully used the program to analyze images of zebrafish and mice, as well as data collected from a commercial light sheet microscope and a commercial confocal microscope.


'/>"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Small but speedy: Short plants live in the evolutionary fast lane
2. GW announces creation of Computational Biology Institute to conduct integrated research
3. George Washington University Computational Biology Director solves 200-year-old oceanic mystery
4. A new computational method for timing the tree of life
5. Using computational biology for the annotation of proteins
6. Kirk, Spock together: Putting emotion, logic into computational words
7. Collaboration to establish new computational resources for metabolomics
8. New research projects to enhance bioinformatics and computational biology tools and methodologies
9. Researchers perform DNA computation in living cells
10. Computational biology: Cells reprogrammed on the computer
11. Computational method dramatically speeds up estimates of gene expression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Speedy computation enables scientists to reconstruct an animal's development cell by cell
(Date:9/16/2014)... pipeline (KXL) would likely increase oil sands extraction, according ... the non-profit organization Near Zero. The results are detailed ... includes both supporters and opponents of the pipeline. ... lead to significantly higher greenhouse gas emissions, with the ... , "This report examines three main scenarios discussed by ...
(Date:9/16/2014)... years after the Hesperides vessel returned to Spain culminating ... have an increasingly clear picture of how the global ... the input of pollutants from the atmosphere is not ... most remote areas of the planet, and it is ... are presented this week in CSIC Residence for Researchers ...
(Date:9/16/2014)... for independence later this week, its Government could face ... fracking is necessary, research has revealed. , The University ... perception of shale gas extraction in the UK since ... of the border are the least supportive of fracking. ... the University,s School of Geography, said: "The clear move ...
Breaking Biology News(10 mins):Keystone XL would likely raise oil sands production and greenhouse gas emissions 2The Malaspina Expedition confirms that pollution reaches even the most remote areas of the ocean 2The Malaspina Expedition confirms that pollution reaches even the most remote areas of the ocean 3Scottish people most sceptical on fracking, survey shows 2Scottish people most sceptical on fracking, survey shows 3
... chief executive officer of DuPont, and Abby Joseph Cohen, ... & Co., will be featured speakers at a University ... to be held Friday, Nov. 2, in Clayton Hall, ... conference is the first in a new series of ...
... of marine microbes have been discovered at two deep-sea ... the MBL (Marine Biological Laboratory) and University of Washingtons ... Their findings, published in the October 5 issue of ... comprehensive, comparative study to date of deep-sea microbial communities ...
... (ESA) is proud to announce its selection of ... as an ESA Fellow acknowledges outstanding contributions in research, ... have have participated actively in ESA affairs and served ... be recognized during the ESA Annual Meeting, which will ...
Cached Biology News:UD hosts conference on knowledge-based partnerships Nov. 2 2Hydrothermal vents: Hot spots of microbial diversity 2Entomological Society of America recognizes 2007 fellows and honorary members 2Entomological Society of America recognizes 2007 fellows and honorary members 3
(Date:9/16/2014)... Longmeadow, MA (PRWEB) September 16, 2014 ... appointment of Brian Highley as CEO of CIRTEC. ... this exciting point for the Company.” noted Brian Highley. ... operational performance while sustaining strong organic growth over the ... CIRTEC’s growth by continuing to improve and expand the ...
(Date:9/16/2014)... N.C. , Sept. 16, 2014  The ... oldest entrepreneurial support organization in the country, today ... Innovators Report . It showed ... North Carolina startups in the ... drew more global investment from a variety of ...
(Date:9/16/2014)... 2014   Synthetic Biologics, Inc. (NYSE ... biologic and drug programs targeting specific pathogens that ... of the Company,s Investor Day in ... bowel syndrome (IBS) program, including its novel, oral ... In the keynote presentation, Mark Pimentel , ...
(Date:9/16/2014)... Pharma Packaging Solutions announced ... for their 89th year in business. Adding ... Packaging Solutions is preparing packaging operations changes ... new procedures. Establishing training and system validation ... Pharma Packaging Solutions will be ready to ...
Breaking Biology Technology:CED's Mid-Year Update to its Innovators Report Shows NC Startups Attracting Investment From Across the Globe with Several High-Profile Investment Deals, IPOs and Acquisitions Signaling Strength of Entrepreneurial Sector 2CED's Mid-Year Update to its Innovators Report Shows NC Startups Attracting Investment From Across the Globe with Several High-Profile Investment Deals, IPOs and Acquisitions Signaling Strength of Entrepreneurial Sector 3CED's Mid-Year Update to its Innovators Report Shows NC Startups Attracting Investment From Across the Globe with Several High-Profile Investment Deals, IPOs and Acquisitions Signaling Strength of Entrepreneurial Sector 4Synthetic Biologics' Statin-Class Candidate for Constipation-Predominant Irritable Bowel Syndrome Detailed at Company's Investor Day 2Synthetic Biologics' Statin-Class Candidate for Constipation-Predominant Irritable Bowel Syndrome Detailed at Company's Investor Day 3Adding Serialization Capabilities and Expanded Capacity, Pharma Packaging Solutions Is Preparing for 89th Year of Business 2
... (Nasdaq: VNDA ), a biopharmaceutical company focused ... for central,nervous system disorders, today announced financial and ... 2008., Vanda reported research and development (R&D) ... million, compared to $5.5 million in the second,quarter ...
... STERIS Corporation,(NYSE: STE ) today announced financial ... 2008. Fiscal 2009 second quarter revenues,increased 10% to $323.1 ... fiscal 2008, driven by strong growth in all three ... million, or $0.48,per diluted share, compared with net income ...
... Genetic Variations Identify Predisposition to Early Cardiovascular,Events in ... Interleukin Genetics,Inc. (Amex: ILI ), announced today ... will present new research findings on,the genetics of ... Symposium (CVGAS), which takes place from Oct. 31 ...
Cached Biology Technology:Vanda Pharmaceuticals Reports Third Quarter 2008 Results 2Vanda Pharmaceuticals Reports Third Quarter 2008 Results 3Vanda Pharmaceuticals Reports Third Quarter 2008 Results 4Vanda Pharmaceuticals Reports Third Quarter 2008 Results 5Vanda Pharmaceuticals Reports Third Quarter 2008 Results 6Vanda Pharmaceuticals Reports Third Quarter 2008 Results 7Vanda Pharmaceuticals Reports Third Quarter 2008 Results 8Vanda Pharmaceuticals Reports Third Quarter 2008 Results 9Vanda Pharmaceuticals Reports Third Quarter 2008 Results 10STERIS Corporation Announces Fiscal 2009 Second Quarter and First Half Results 2STERIS Corporation Announces Fiscal 2009 Second Quarter and First Half Results 3STERIS Corporation Announces Fiscal 2009 Second Quarter and First Half Results 4STERIS Corporation Announces Fiscal 2009 Second Quarter and First Half Results 5STERIS Corporation Announces Fiscal 2009 Second Quarter and First Half Results 6STERIS Corporation Announces Fiscal 2009 Second Quarter and First Half Results 7STERIS Corporation Announces Fiscal 2009 Second Quarter and First Half Results 8STERIS Corporation Announces Fiscal 2009 Second Quarter and First Half Results 9STERIS Corporation Announces Fiscal 2009 Second Quarter and First Half Results 10STERIS Corporation Announces Fiscal 2009 Second Quarter and First Half Results 11Interleukin Genetics to Present New Findings at the 11th Cardiovascular Genomics and Atherosclerosis Symposium 2Interleukin Genetics to Present New Findings at the 11th Cardiovascular Genomics and Atherosclerosis Symposium 3Interleukin Genetics to Present New Findings at the 11th Cardiovascular Genomics and Atherosclerosis Symposium 4
Applications: Western blotting ...
...
... efficiencies and the chemistry of light production ... benefit that they require simple triggering conditions ... This benefit has been exploited to great ... compounds can also be easily modified to ...
ssDNA from PCR DNA in less than 1 hour. No gels, columns, or slurries. Sequence from high quality ssDNA: clearer reads, longer runs....
Biology Products: