Navigation Links
Speedy computation enables scientists to reconstruct an animal's development cell by cell
Date:7/20/2014

vidual cells as biological structures emerge in a developing embryo. Since then, Keller has been perfecting the system so he can use it to follow the development of an organism's early nervous system.

"We want to reconstruct the elemental building plan of animals, tracking each cell from very early development until late stages, so that we know everything that has happened in terms of cell movement and cell division," Keller says. "In particular, we want to understand how the nervous system forms. Ultimately, we would like to collect the developmental history of every cell in the nervous system and link that information to the cell's final function. For this purpose, we need to be able to follow individual cells on a fairly large scale and over a long period of time."

It takes more than a week for the nervous system to become functional in an embryonic mouse. Even in the fruit fly, the process takes a day. Following development for that long means Keller's team must image tens of thousands of cells at thousands of time points, and that adds up to terabytes of data. "We can get good image data sets, but if we want to reconstruct them, this is something that we can't really do without help from the computer," Keller says.

Amat, a bioinformatics specialist on Keller's team, and his colleagues have solved that problem with the new computational method that identifies and tracks dividing cells as quickly as their high-speed microscope can capture images. The process is largely automated, but incorporates a manual editing step to improve accuracy for a small percentage of cells that are difficult to track computationally.

Keller's team has been grappling with how to interpret this kind of imaging data since 2010. The problem was challenging not only because of the sheer volume of data his light sheet microscope produced, but also because of the data's complexity. Cells in a developing embryo have different shapes and behaviors and can
'/>"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Small but speedy: Short plants live in the evolutionary fast lane
2. GW announces creation of Computational Biology Institute to conduct integrated research
3. George Washington University Computational Biology Director solves 200-year-old oceanic mystery
4. A new computational method for timing the tree of life
5. Using computational biology for the annotation of proteins
6. Kirk, Spock together: Putting emotion, logic into computational words
7. Collaboration to establish new computational resources for metabolomics
8. New research projects to enhance bioinformatics and computational biology tools and methodologies
9. Researchers perform DNA computation in living cells
10. Computational biology: Cells reprogrammed on the computer
11. Computational method dramatically speeds up estimates of gene expression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Speedy computation enables scientists to reconstruct an animal's development cell by cell
(Date:12/24/2014)... launch in December 2014, the 1U™ app has ... to remember their usernames and passwords through replacing the antiquated ... assist people who have struggled to remember usernames and passwords, ... focuses on redefining identity, announced today that it is offering ...
(Date:12/19/2014)... Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has announced the addition ... Systems Market" report to their offering. ... security market is estimated to grow at a CAGR of ... a larger share in this market, Canada ...
(Date:12/17/2014)... , Dec. 15, 2014  HITLAB SM announced ... audit to confirm its adherence to current U.S. Food ... to conduct regulated smart device and smart phone application ... research quality. "HITLAB is determined to improve ...
Breaking Biology News(10 mins):1U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2
... Researchers at the University of Cambridge have discovered a ... within the body, a breakthrough that could lead to ... , Dr. Pietro Mastroeni, Professor Duncan Maskell at ... pioneered the integration of mathematical models with observational data ...
... had narrow, pointed teeth, which were more suited to tearing ... then grind their food? Until recently many researchers have assumed ... their muscular stomach these then acted as a kind of ... correct, as scientists at the universities of Bonn and Tübingen ...
... regulate neuronal signaling in the brain and spinal cord ... mouse with a mutation affecting a neuronal zinc target, ... modulating signaling among the neurons. Significantly, they found the ... as children with the genetic disorder called "startle disease," ...
Cached Biology News:Researchers map spread of pathogens in the human body 2Dinosaurs -- stones did not help with digestion 2Dinosaurs -- stones did not help with digestion 3Zinc plays important role in brain circuitry 2
(Date:1/22/2015)... today announces the firm brokered a long-term lease totaling 202,492 ... company, at Two Ledgemont Center in Lexington, Massachusetts ... and Brian Cohen , senior vice president, represented Shire ... Hayden Ave. Photo - http://photos.prnewswire.com/prnh/20150122/170765 ...
(Date:1/22/2015)... 2015 Pipette.com has added the ... comprehensive portfolio of Eppendorf products. , The Eppendorf Centrifuge ... Centrifuge 5424/5424 R and receive the following:, ... plus or Eppendorf Reference 2 ,     3 ...
(Date:1/22/2015)... Denville, NJ (PRWEB) January 22, 2015 ... shearing technologies such as the Bioruptor® and complete ... semi-automation system for chromatin immunoprecipitation, alleviating the need ... reagents and controls needed for ChIP of histones ...
(Date:1/22/2015)... , Jan. 22, 2015  Derma Sciences, Inc. ... company focused on advanced wound care, announces that ... tissues, have been added to the Premier, Inc. ... the opportunity for the AMNIOEXCEL® and AMNIOMATRIX® product ...
Breaking Biology Technology:Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5
... Businesses Find the ... Best Leaders, ... is featured in the September issue of New Jersey Business magazine.,The ... Association (NJBIA), the largest state employer organization in,the country. The article, ...
... N.C., Sept. 5 A study in ... the use of the GlycoMark,1,5-anhydroglucitol (1,5-AG) blood ... especially to target postprandial hyperglycemia (elevated,after-meal glucose ... achieving optimal glycemic control and reducing the ...
... CRY ),a biomaterials, medical device and tissue ... vice president, chief operating officer,and chief financial officer ... Bear Stearns 20th Annual Healthcare Conference on Monday, ... will also present at the First Albany,Capital Regenerative ...
Cached Biology Technology:Boyden's Summit Practice Featured in the September Issue of New Jersey Business Magazine 2Study Supports Use of GlycoMark Blood Test to Evaluate Therapy in Children with Diabetes 2
...
GLP expression profiling service on the Affymetrix platform. Starting material can be blood, tissue or RNA. 5 day turnaround. Standard and custom post analyses of microarray data available....
... enables early selection of the best ... quantitative data for sensitivity, dynamic range, ... Furthermore quantitative antibody fingerprints can be ... your antibodies., The full-service package includes ...
... allows for rapid, convenient, and efficient Denatured ... process utilizes a spin column to make ... concentration of proteins which were electro-eluted in ... ion exchangers, offering high binding capacity fo ...
Biology Products: