Navigation Links
Speedy computation enables scientists to reconstruct an animal's development cell by cell
Date:7/20/2014

vidual cells as biological structures emerge in a developing embryo. Since then, Keller has been perfecting the system so he can use it to follow the development of an organism's early nervous system.

"We want to reconstruct the elemental building plan of animals, tracking each cell from very early development until late stages, so that we know everything that has happened in terms of cell movement and cell division," Keller says. "In particular, we want to understand how the nervous system forms. Ultimately, we would like to collect the developmental history of every cell in the nervous system and link that information to the cell's final function. For this purpose, we need to be able to follow individual cells on a fairly large scale and over a long period of time."

It takes more than a week for the nervous system to become functional in an embryonic mouse. Even in the fruit fly, the process takes a day. Following development for that long means Keller's team must image tens of thousands of cells at thousands of time points, and that adds up to terabytes of data. "We can get good image data sets, but if we want to reconstruct them, this is something that we can't really do without help from the computer," Keller says.

Amat, a bioinformatics specialist on Keller's team, and his colleagues have solved that problem with the new computational method that identifies and tracks dividing cells as quickly as their high-speed microscope can capture images. The process is largely automated, but incorporates a manual editing step to improve accuracy for a small percentage of cells that are difficult to track computationally.

Keller's team has been grappling with how to interpret this kind of imaging data since 2010. The problem was challenging not only because of the sheer volume of data his light sheet microscope produced, but also because of the data's complexity. Cells in a developing embryo have different shapes and behaviors and can
'/>"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Small but speedy: Short plants live in the evolutionary fast lane
2. GW announces creation of Computational Biology Institute to conduct integrated research
3. George Washington University Computational Biology Director solves 200-year-old oceanic mystery
4. A new computational method for timing the tree of life
5. Using computational biology for the annotation of proteins
6. Kirk, Spock together: Putting emotion, logic into computational words
7. Collaboration to establish new computational resources for metabolomics
8. New research projects to enhance bioinformatics and computational biology tools and methodologies
9. Researchers perform DNA computation in living cells
10. Computational biology: Cells reprogrammed on the computer
11. Computational method dramatically speeds up estimates of gene expression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Speedy computation enables scientists to reconstruct an animal's development cell by cell
(Date:10/16/2014)... Northridge, Calif. (October 16, 2014) – Post-menopausal women ... effect on hormone levels or genital bleeding, after ... of an investigational fermented soy germ-based nutritional supplement ... according to a new peer-reviewed pilot study reported ... Society (NAMS) annual scientific meeting. , "These ...
(Date:10/15/2014)... Gauß-Allianz has admitted Johannes Gutenberg University Mainz (JGU) ... science hub continues to maintain a significant nationwide ... , "The acceptance of Johannes Gutenberg University Mainz ... a milestone in the national and international competition ... state of Rhineland-Palatinate can be proud that Mainz ...
(Date:10/15/2014)... 15, 2014   Neurotechnology , a provider ... availability of the VeriLook Surveillance 3.0 software ... real-time biometric face identification using live video streams ... The new version not only identifies faces in ... objects while they are moving through the video ...
Breaking Biology News(10 mins):S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3
... researchers from the National Institute of Standards and ... of Maryland has made nano-sized sensors that detect ... pesticides and other productsthat offer several advantages over ... and the ability to detect one or several ...
... and freshwater cichlids in the western branch of the ... surroundinga thriving ecosystem around Lake Kivu. Natural hazards ... borders Rwanda and the Democratic Republic of Congo have ... highland forests for fuel use and subsistence farming has ...
... TOBAGOFlower color in plants is determined by pigments such ... the ultimate color displayed is dependent not only on ... cell shape, presence of metal ions, and pH, among ... color has allowed plant geneticists to engineer new hues, ...
Cached Biology News:Nanowire-based sensors offer improved detection of volatile organic compounds 2Benchmarking a slice of Africa; preserving biodiversity through science 2Benchmarking a slice of Africa; preserving biodiversity through science 3Benchmarking a slice of Africa; preserving biodiversity through science 4Benchmarking a slice of Africa; preserving biodiversity through science 5Engineering blue-hued flowers 2
(Date:10/22/2014)... 2014 Shimadzu Scientific Instruments introduces its ... for the pain management and clinical markets. The software ... review by allowing users to highlight and review results ... QuantAnalytics allows analysts to filter results by group or ... by eliminating the need to sift through analytes of ...
(Date:10/22/2014)... Cranford, NJ (PRWEB) October 22, 2014 ... technologies and services – has been working with a ... Health and New Haven Farms Community Farming Collaborative to ... iPad-based ePRO solution. The study, which started in ... Wellness program that provides participants weekly exposure to and ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 Grace Century, ... and healthcare projects, announces the addition of Dr. ... to its advisory team. Dr. Siddiqui will provide further ... , A graduate of University College Medical School ... degreed in medicine in 2001. With further certification as ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 According ... Market by Service Type (Consulting, Integration, Deployment & ... by Deployment Model (Public, Private, Others (Hybrid & ... MarketsandMarkets, defines and segments the Cloud Professional Services ... and forecasting of revenues. It also identifies the ...
Breaking Biology Technology:Shimadzu Releases QuantAnalytics Open Access LCMS Software Package for Clinical Applications 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3Dr. Yousef Siddiqui joins the Grace Century Advisory Team 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5
... Madison, Wis. The next alternative fuel source for ... the basement of a restaurant. , ,The Wisconsin Department ... grant will be awarded to the Madison Environmental Group ... Madison Environmental will be working with the restaurant chain ...
... and excursions relevant to the world of Midwest technology ... week, the Midwest Venture Summit was held in Chicago ... were sponsored by the Chicago chapter of the Keiretsu ... registered to attend, an unofficial count estimated that half ...
... VCT image of the carotid arteries that supply blood to ... University of Michigan Health System are using the system to ... Business Wire. Milwaukee GE Healthcare ... that give physicians a non-invasive view of the heart and ...
Cached Biology Technology:Environmental group works to run cars on Culver's old frying oil 2Environmental group works to run cars on Culver's old frying oil 3Midwest Venture Summit disappoints; Cato grades Midwest governors 2Midwest Venture Summit disappoints; Cato grades Midwest governors 3Midwest Venture Summit disappoints; Cato grades Midwest governors 4GE Healthcare launches new medical scanner, places another in hospitals 2GE Healthcare launches new medical scanner, places another in hospitals 3
... system automates the denaturation and hybridization steps ... convenience for clinical and research personnel. The ... of sample types, is easy to use, ... 50% while ensuring overall precision and accuracy ...
... fluorescent nucleic acid dye which binds only ... nuclear counterstain, propidium iodide stains the nucleus ... The fluorescent red color provides excellent contrast ... FITC, Cy2 or AMCA. Propidium Iodide ...
... Mouse RAW 264. 7 cells were cultured ... harvested at the log phase of growth. ... native forms, cells were fixed in acetone-methanol. ... mm) adhesive coated slide, with each wells surface ...
... Mouse P815 cells were cultured in DMEM ... In order to keep the antigens in ... The cells are arrayed on a 12-well ... surface specifically treated to enhance cellular attachment and ...
Biology Products: