Navigation Links
Speeding up drug discovery with rapid 3-D mapping of proteins
Date:5/30/2012

LA JOLLA, CA----A new method for rapidly solving the three-dimensional structures of a special group of proteins, known as integral membrane proteins, may speed drug discovery by providing scientists with precise targets for new therapies, according to a paper published May 20 in Nature Methods.

The technique, developed by scientists at the Salk Institute for Biological Studies, provides a shortcut for determining the structure of human integral membrane proteins (hIMPs), molecules found on the surface of cells that serve as the targets for about half of all current drugs.

Knowing the exact three-dimensional shape of hIMPs allows drug developers to understand the precise biochemical mechanisms by which current drugs work and to develop new drugs that target the proteins.

"Our cells contain around 8,000 of these proteins, but structural biologists have known the three-dimensional structure of only 30 hIMPs reported by the entire field over many years," says Senyon Choe, a professor in Salk's Structural Biology Laboratory and lead author on the paper. "We solved six more in a matter of months using this new technique. The very limited information on the shape of human membrane proteins hampers structure-driven drug design, but our method should help address this by dramatically increasing the library of known hIMP structures."

Integral membrane proteins are attached to the membrane surrounding each cell, serving as gateways for absorbing nutrients, hormones and drugs, removing waste products, and allowing cells to communicate with their environment. Many diseases, including Alzheimer's, heart disease and cancer have been linked to malfunctioning hIMPs, and many drugs, ranging from aspirin to schizophrenia medications, target these proteins.

Most of the existing drugs were discovered through brute force methods that required screening thousands of potential molecules in laboratory studies to determine if t
'/>"/>

Contact: Andy Hoang
ahoang@salk.edu
619-861-5811
Salk Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Systems biology brings hope of speeding up drug development
2. Graphene may hold key to speeding up DNA sequencing
3. Chemical equator discovery will aid pollution mapping
4. Sirtris review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery
5. Groundbreaking discovery may lead to stronger antibiotics
6. Discovery of natural compounds that could slow blood vessel growth
7. Nanoscopic screening process to speed drug discovery
8. FSU researchers discovery leads to $1.5 million grant, potential new treatment of liver fibrosis
9. New $11 million center to speed production of new compounds for drug discovery
10. Discovery of giant roaming deep sea protist provides new perspective on animal evolution
11. New discovery may enhance MRI scans, lead to portable MRI machines
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Speeding up drug discovery with rapid 3-D mapping of proteins
(Date:9/30/2014)... think of nature as something that we enjoy when we ... Or do we think of ourselves as a part of ... what about a house? , The answers to these ... our actions, our speech and in cultural artifacts. , A ... Washington, the American Indian Center of Chicago and the Menominee ...
(Date:9/30/2014)... WASHINGTON, D.C., September 30, 2014--Sea monkeys have captured the ... of their easily observable life cycle -- sold as ... and mate given little more than a tank of ... a shorter-term pattern: Like other zooplankton, brine shrimp vertically ... conditions, coming closer to the surface at night and ...
(Date:9/30/2014)... engineers, led by Clemson University associate professor Brian ... from the U.S. Department of Energy,s Experimental Program ... positive impact on South Carolina in the advancement ... , "Understanding the scientific and engineering needs for ... nuclear technologies is imperative if South Carolina is ...
Breaking Biology News(10 mins):The cultural side of science communication 2Laser-guided sea monkeys show how zooplankton migrations may affect global ocean currents 2Researchers get $5.25 million to advance nuclear technologies in South Carolina 2
... anywhere, a researcher at the Hebrew University of Jerusalem has ... the brain of a mammal. , Dr. Adi Mizrahi ... of Life Sciences at the Hebrew University, used mouse models ... undifferentiated cellular sphere into a rich and complex cell. This ...
... cure type 1 diabetes by allowing people to ... defective pancreas, medical researchers here have reported that they ... cord blood to produce insulin. , The researchers announced ... research, in the June 2007 issue of the medical ...
... organism that produces the world’s most lethal toxin is revealed today. ... Clostridium botulinum and less than 2 kg — the weight of ... on the planet. Very small amounts of the same toxin are ... , The genome sequence shows that C. botulinum doesn’t have subtle ...
Cached Biology News:A first -- Hebrew University scientist observes brain cell development in 'real time' 2Adult stem cells from human cord umbilical cord blood successfully engineered to make insulin 2Adult stem cells from human cord umbilical cord blood successfully engineered to make insulin 3Genome of Clostridium botulinum reveals the background to world's deadliest toxin 2Genome of Clostridium botulinum reveals the background to world's deadliest toxin 3
(Date:9/30/2014)... (PRWEB) September 30, 2014 Proove ... medicine, is excited to announce a new genetic test ... The Proove Pain Perception Test will provide physicians ... and why pain tolerance levels are stratified between individuals. ... identify whether a person has a genetic predisposition that ...
(Date:9/30/2014)... September 30, 2014 Fast, ... of chemistry in documents ChemAxon ... and consulting services for life science research, launches ... generate Markush structures from documents. Markush ... property, however generating and understanding Markush structures is ...
(Date:9/30/2014)... 30, 2014 BioHealth Innovation, Inc. ... biohealth innovations and increasing access to early-stage funding in ... venture capitalist, Tania Fernandez , Ph.D., has joined ... will be a member of the management team for ... to $50 million in seed and early-stage equity investments ...
(Date:9/30/2014)... 2014 The custom stainless steel fabrication ... Show 2014. The Boston Area Chapter of ISPE (International ... day-long event for Wed., Oct. 1 at Gillette Stadium ... the largest in ISPE Boston’s long history, with more ... attendees expected. , HOLLOWAY AMERICA President David Simpson ...
Breaking Biology Technology:Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 3ChemAxon Introduces ChemCurator for Chemical Information Extraction and Markush Structure Creation 2Seasoned Life Sciences Venture Capitalist Tania Fernandez Joins BHI to Help Manage New BioHealth Gap Fund 2HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 2HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 3
... Dec. 9 The results of a new study on ... 30 sites around the country, will be published in the ... Salloway, MD, MS, director of the Butler Hospital Memory and ... the Warren Alpert Medical School of Brown University, says that ...
... , SAN DIEGO, Dec. 9 ... life-saving medicines specifically designed to enhance the perfusion and ... and other gas delivery, today announced that the European ... MP4CO for the treatment of sickle cell disease. This ...
... ... Platform for High Throughput and High Content Screening. , ... Basel, Switzerland and Granada, Spain (PRWEB) December 8, ... discovery and life science research, and Fundación MEDINA (Centro de Excelencia en ...
Cached Biology Technology:Butler Hospital Neurologist Lead Author of Ground Breaking Bio-Engineered Treatment Study for Alzheimer's Disease 2Sangart, Inc. Receives European Orphan Drug Designation for the Use of MP4CO in Patients With Sickle Cell Disease 2Sangart, Inc. Receives European Orphan Drug Designation for the Use of MP4CO in Patients With Sickle Cell Disease 3MEDINA Scientists Select Genedata Screener for Lead Discovery from Natural Products 2MEDINA Scientists Select Genedata Screener for Lead Discovery from Natural Products 3MEDINA Scientists Select Genedata Screener for Lead Discovery from Natural Products 4
... Immunogen: synthetic peptide corresponding to the ... dopamine receptor, conjugated to KLH. The ... rat and mouse gene. Physical form: ... containing 0.01% sodium azide. Titertest method: ...
... The National Collection of Pathogenic ... authenticated human pathogenic viruses in ... is able to supply the ... from them, to the scientific ...
... The flexible and easy ... used to control all members ... family. It features a clear ... visual assay setup, user-friendly and ...
Roll of Mesh 5m x 25cm...
Biology Products: