Navigation Links
Speed plays crucial role in breaking protein's H-bonds
Date:10/30/2007

>It wasnt until the team, using large-scale computing facilities, was able to slow down the application of pressure in their models by a factor of 10 or 20, that they understood the discrepancy. At those speeds, which are much closer to the speeds at which pressure is applied in living cells and tissues, their study showed a change in behavior of the hydrogen bonds.

EXPLAINING THE PUZZLING BEHAVIOR

Buehler and undergraduate student Xuefeng Chen, graduate student Sinan Keten, and Theodor Ackbarow, a graduate student from the University of Stuttgart working in Buehlers lab at MIT, set up a six-month computer simulation study. They worked with two different types of common proteins: vimentinan alpha-helical filament protein that plays an important role in cellular signaling and stabilityand amyloidal fibrilsbeta-folded proteins. These protein motifs form the basis of many natural materials, such as hair, hoof, wool, spider silk, and the prions that build up in the brains of Alzheimers patients.

Hydrogen bonds are the basic chemical bonds that hold together proteins, similar to trusses and beams in buildings, and play a key role in controlling the behavior of these structures.

The researchers placed strain on the proteins by pulling on the ends, trying different pressures applied at different rates. They found that the hydrogen bonds in both the alpha-helical-type vimentin proteins and the beta-fibril-type amyloids behaved similarly. At higher rates, hydrogen bonds begun to break apart one at a time, earlier in the process. But when the pressure is applied more slowly, the bonds hold out longer, but break three at a time when they go.

The slow deformation rate in proteins is most relevant in normal biological function, but the fast rate could be important during tissue injuries such as the shock impact in accidents and during formation of fractures in biological tissues, said Buehler.

This work adds an important
'/>"/>

Contact: Denise Brehm
brehm@mit.edu
617-253-8069
Massachusetts Institute of Technology, Department of Civil and Environmental Engineering
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. First atlas of key brain genes could speed research on cancer, neurological diseases
2. Influenza vaccine uses insect cells to speed development
3. NIH Calls on Scientists to Speed Public Release of Research Publications
4. Computational Method Speeds Mapping of Cell Signaling Networks
5. FDA Works To Speed The Advent Of New, More Effective Personalized Medicines
6. Rabies spread speeds up
7. New technique may speed DNA analysis
8. Scientists discover gene that controls speed of tuberculosis development
9. Flies on speed offer insight into the roles of dopamine in sleep and arousal
10. Stressed cells spark DNA repair missteps and speed evolution
11. UW scientists report a new method to speed bird flu vaccine production
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... 24, 2015 Research and Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) ... - Global Strategic Business Report" report to their offering. ... Biometrics in US$ Thousands by the following Segments: Face Biometrics, and ... Canada , Japan , ... Middle East & Africa , and ...
(Date:3/23/2015)... --  HOYOS Labs , a leading global authentication infrastructure ... Company will demonstrate multiple biometrics-based technologies under its identity ... on March 23 through 25, 2015, in ... IEEE Biometric Open Protocol Standard; free biometrics-based consumer app, ... system. BOPS was invented by HOYOS Labs and contributed ...
(Date:3/20/2015)... , Mar. 19, 2015 Research and Markets ... "Hand Geometry - Global Strategic Business Report" report to ... for Hand Geometry in US$ Thousands. The report provides separate ... Japan , Europe , ... , and Rest of World. Annual estimates and ...
Breaking Biology News(10 mins):Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4
... - A team comprised of undergraduate students from Stevens ... national poster contest hosted by the International Society for ... research conducted by the students and was held last ... Calif. The winning poster, titled "Evaluation of a ...
... Foundation is pleased to announce the 2009 winner of ... Pritzker Distinguished Service Professor Emeritus, Departments of Medicine and ... The Prize was inaugurated in 2008 to ... Foundation, honoring those who have enlightened researchers in the ...
... , ... PALM HARBOR, Fla., Dec. 2 Communication Intelligence Corporation ... electronic signature solutions for business process automation in the ... verification and Docubase Systems Inc. ("Docubase"), a leading International ...
Cached Biology News:CIC Teams with Docubase Systems to Deliver eSignature Enabled Document Management Solutions 2CIC Teams with Docubase Systems to Deliver eSignature Enabled Document Management Solutions 3CIC Teams with Docubase Systems to Deliver eSignature Enabled Document Management Solutions 4
(Date:5/4/2015)... 4, 2015   St. Jude Children,s Research ... computer tool for finding genetic alterations that play ... difficult to identify with whole-genome sequencing. The findings ... Methods . The tool is an ... by Regression Tree in Next Generation Sequencing. ...
(Date:5/4/2015)... May 4, 2015 /PRNewswire/ - The Fight Against ... pleased to announce the formation of Turnstone Biologics ... treatments for cancer that harness the patient,s own ... unique collaboration between the Children,s Hospital of ... McMaster University, the Ontario Institute for Cancer Research ...
(Date:5/4/2015)... KONG , May 4, 2015 China ... the "Company"), China,s leading provider ... processing and stem cell storage services, today announced that ... Limited ("Golden Meditech"), a Hong Kong ... Company, has entered into an agreement (the "Agreement") to ...
(Date:5/4/2015)... (PRWEB) May 04, 2015 ... for patients with arm and hand impairments by ... at its Oakbrook Terrace network site. , Secured ... Armeo®Spring is a highly-regarded treatment option for patients ... the Armeo®Spring, Marianjoy becomes one of just four ...
Breaking Biology Technology:Scientists dramatically improve method for finding common genetic alterations in tumors 2Scientists dramatically improve method for finding common genetic alterations in tumors 3Scientists dramatically improve method for finding common genetic alterations in tumors 4Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 2Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 3China Cord Blood Corporation Receives Notice of a Transaction Regarding its 7% Senior Convertible Notes Due 2017 Held by KKR 2China Cord Blood Corporation Receives Notice of a Transaction Regarding its 7% Senior Convertible Notes Due 2017 Held by KKR 3Marianjoy Acquires Armeo®Spring Arm and Hand Rehabilitation Exoskeleton at Oakbrook Terrace Facility 2
... so much time trying to be the next Silicon Valley? ... is to become a Midwest carbon copy of Silicon Valley, we ... labor and general population are so vast that we could spend ... come close. If its true that the only way for ...
... Toni Sikes of Guild.com , , WTN: What's the ... Sikes: In my opinion, it will be the continuous ... technology and e-commerce companies lies in better connecting customers with ... and technology communities must improve every element that surrounds our ...
... - until now. Truth be told - and probably something a ... everyone is going right, I'll move left just to avoid the ... was that it was just another technology-enabled fad. Any fool with ... could read it. Of course, there was, initially, a bit of ...
Cached Biology Technology:What If We Cut Our Own Path? 2What If We Cut Our Own Path? 3The Next Big Thing in E-Commerce - Guild.com CEO comments on Wisconsin's technology vision 2The Blog Nation 2The Blog Nation 3
For use with SSP products or any application requiring agarose gel separation • Multiple formats available to meet various throughput needs • Includes replacement parts for each un...
...
Request Info...
Human RUNX2/CBFA1 MAb (Clone 232902)...
Biology Products: