In co-operation with a research group from Singapore, scientists at University of Copenhagen have shown that immature sugar molecules in the form of truncated O-glycans aid growth properties of cancer cells. Previously, scientists have not been able to decode the significance of these truncated O-glycans, and therefore, the results, which were recently published in the journal PNAS, represent an important contribution to understanding the growth of cancer cells as well as the work towards developing a cure that can limit or stop the growth.
Catharina Steentoft, PhD student at Copenhagen Center for Glycomics and one of the scientists behind the results, stresses that this is basic science and there is still a long way from the results to actually developing a treatment or using them for diagnostic purposes. The results are still a cause for optimism, though.
"This is part of how we will proceed in the battle against cancer. When you know a certain process is important for the development of cancer you can start to consider ways to affect this process in a way that stops the cancer cell from taking advantage of it," explains Catharina Steentoft.
Sugar molecules affect proteins
Sugar molecules play an important role in almost all of the processes taking place in the body. One of the ways in which sugar molecules affect us is through glycosylation, a process where sugar molecules are attached to proteins. The proteins are basically the building bricks of the body, whilst sugar molecules affect the proteins, and therefore play a significant role in the human organism. A flaw in a chain of sugar molecules can lead to protein malfunctioning and disease.
As early as 1982, scientists around the world realised the importance of sugar molecules for cancer. The American doctor and scientist Georg F. Springer discovered that a certain type of sugar molecules, the truncated O-glycans, were particularly prominent in c
|Contact: Catharina Steentoft|
University of Copenhagen