Navigation Links
Specific protein may help neurons fix themselves in Parkinson's patients
Date:7/22/2010

EAST LANSING, Mich. A Michigan State University researcher is working to uncover how a protein known as parkin may help nerve cells fight off damage from Parkinson's disease, a strategy that could lead to new therapies for the degenerative ailment.

John Goudreau, an osteopathic physician and director of MSU's Translational Neurobiology Research Unit, believes parkin can rescue certain neurons from injury induced by Parkinson's disease.

He has been awarded $1.5 million from the National Institutes of Health's National Institute of Neurological Disorders and Stroke to test his hypothesis.

"Parkinson's is a progressive disease, and much of the research has been focused on slowing that progression by preventing cell injury and death," said Goudreau, who holds appointments in MSU's departments of Neurology and Pharmacology/Toxicology in the College of Osteopathic Medicine. "But we are looking at why some neurons in the brain are able to fight off the disease through a unique ability to revive after being hit with an injury that kills other cells."

There is a "selective vulnerability" with Parkinson's disease, he said, where nerve cells in the mid-brain are damaged while cells in the hypothalamic region of the brain are spared since they have the capacity to quickly bounce back after being damaged.

Goudreau's research team has discovered that the protein parkin is essential for these hypothalamic neurons to recover.

"What we now want to find out is how parkin facilitates this recovery," said Goudreau, who has been studying Parkinson's disease for nearly a decade at MSU and has received more than $2 million in external funding for clinical and translational research.

Using human cell cultures and mice, the research team will attempt to isolate exactly what the parkin protein is doing and how it helps neurons return to health after being damaged. Two theories: Parkin may allow cells to rebound from injury by aiding in energy production within the cell, or it may improve a cell's ability to dispose of other proteins damaged by Parkinson's disease.

Either way, Goudreau said, understanding the steps underlying parkin's ability to promote neuron recovery will identify targets for therapies to slow the progression of Parkinson's disease.

"From a clinical standpoint, once a Parkinson's patient presents symptoms and seeks treatment, many neurons in the brain have already been injured and many cells are already dead," he said. "But there is a population of injured neurons that still have the potential to recover.

"Understanding how parkin promotes recovery from injury may allow us to provide cells injured by Parkinson's disease the necessary tools to survive."


'/>"/>

Contact: Jason Cody
codyja@msu.edu
517-432-0924
Michigan State University
Source:Eurekalert  

Related biology news :

1. Study reveals specific gene in adolescent men with delinquent peers
2. The quest for specific anti-inflammatory treatment
3. The genetics of fear: Study suggests specific genetic variations contribute to anxiety disorders
4. Researchers identify specific lung cancer susceptibility gene
5. New tool isolates RNA within specific cells
6. Specific genetic cause of fetal alcohol-related developmental disorders found
7. LSUHSC research helps link schizophrenia to specific DNA region
8. Ben-Gurion University Alzheimers researcher demonstrates specific immune response to vaccine
9. Gene-based stem cell therapy specifically removes cell receptor that attracts HIV
10. Genome mapping technique speeds process of finding specific genes
11. Specific lymph node radiotherapy is well-tolerated after surgery in early breast cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Specific protein may help neurons fix themselves in Parkinson's patients
(Date:3/15/2016)... 15, 2016 --> ... Transparency Market Research "Digital Door Lock Systems Market - Global ... 2023," the global digital door lock systems market in terms ... and is forecast to grow at a CAGR of 31.8% ... and medium enterprises (MSMEs) across the world and high industrial ...
(Date:3/14/2016)... Allemagne, March 14, 2016 ... - --> - Renvoi : image disponible ... --> --> DERMALOG, ... fournit de nouveaux lecteurs d,empreintes digitales pour l,enregistrement ... DERMALOG sera utilisé pour produire des cartes d,identité ...
(Date:3/10/2016)... , March 10, 2016 ... market research report "Identity and Access Management Market by ... Compliance, and Governance), by Organization Size, by Deployment, by ... published by MarketsandMarkets, The market is estimated to grow ... Billion by 2020, at a Compound Annual Growth Rate ...
Breaking Biology News(10 mins):
(Date:5/4/2016)... ... 04, 2016 , ... Nutrafol®, a first-to-market smart-supplement for healthy ... stress related hair loss. With patent-pending formulas for both female hair loss and ... the medical and salon channels nationwide. , Dermatologists, Plastic Surgeons and hair ...
(Date:5/3/2016)... ... 03, 2016 , ... Flagship Biosciences, the leader in ... Board of Directors. Dr. Gillett recently retired from Charles River Laboratories (CRL), where, ... Scientific Officer. A board-certified veterinary pathologist, Dr. Gillett joined Charles River in 1999 ...
(Date:5/3/2016)... , ... May 03, 2016 , ... According to world ... for definitive prostate cancer treatment, patients traditionally had two main treatment options: surgery or ... would be made. , New technology has enabled doctors to administer higher doses ...
(Date:5/2/2016)... PHILADELPHIA, PA (PRWEB) , ... May 02, 2016 ... ... is proud to report on the pre-launch success of their revolutionary, veterinarian-designed product ... allowing cats to stalk, trap, and play with their food the way nature ...
Breaking Biology Technology: