Navigation Links
Specific protein may help beta cells survive in type 1 diabetes
Date:6/9/2014

In the healthy pancreas of someone without type 1 diabetes (T1D), the hormone insulin (essential for turning food into energy) is produced, stored, and released in a normal "factory-like" process within pancreatic beta cells in response to glucose in the diet. Early in the course of T1D, however, excessive or pathologic stress in beta cells compromises their ability to properly secrete insulin, triggering a cascade of events ultimately contributing to the beta cell death. Over the past several years, JDRF-funded researchers have found evidence that beta cell stress may play a role in the onset of T1D, and are exploring possible ways to stop it from occurring, thus potentially protecting beta cell health and maintaining normal beta cell function. In April, JDRF-funded researchers in Finland released new findings in the journal CellPress that add another piece to the puzzle of beta cell stress and T1D.

Led by Dr. Mart Saarma, Dr. Maria Lindahl, and Dr. Timo Otonkoski of the University of Helsinki, along with other investigators, the study showed that a protein called MANF (mesencephalic astrocyte-derived neurotrophic factor) may help protect beta cells from experiencing excessive or pathologic stress response. In the study, mice deficient in the protein developed rapid-onset of T1D due to a decrease in beta cell mass after birth. In contrast, overexpression of the MANF protein in mice resulted in increased beta cell regeneration and promoted beta cell survival in this mouse model of T1D. The study indicates that MANF protein may thwart beta cell stress, promoting the proliferation and survival of beta cellsinformation that could prove valuable in the translational development of beta cell survival therapies for humans with T1D in the future.

These findings come one year into a three-year research grant from JDRF to support the discovery and development of potential methods to protect and regenerate beta cells in people with T1D. Still, more research needs to be done in additional animal models of T1D, as one model alone does not precisely mimic the complex pathogenesis of T1D in humans. Additionally, preliminary findings will be validated with human beta cells. The growing knowledge of beta cell biology, thanks to studies like this one, helps to open multiple paths toward potentially preserving and restoring beta cell function in people with T1D.


'/>"/>

Contact: Tara Burd
tburd@jdrf.org
JDRF
Source:Eurekalert

Related biology news :

1. CSIC develops a software able to identify and track an specific individual within a group
2. Poor coverage of specific gene sets in exome sequencing gives cause for concern
3. Sex-specific changes in cerebral blood flow begin at puberty, Penn study finds
4. Scientists discover the specific types of macrophages that affect Crohns disease severity
5. UCI study finds specific genetic cue for sudden cardiac death syndrome
6. Scientists find genetic mechanism linking aging to specific diets
7. Shortening guide RNA markedly improves specificity of CRISPR-Cas nucleases
8. Wild sparrow study traces social behaviors in the field to specific gene
9. A single-domain antibody that specifically recognizes amyloid-beta 42 oligomers
10. Each food fish can cause specific allergies
11. Wayne State researchers discover specific inhibitor for rheumatoid arthritis treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... SEATTLE , April 5, 2017  The Allen ... the Allen Cell Explorer: a one-of-a-kind portal and dynamic ... large-scale 3D imaging data, the first application of deep ... edited human stem cell lines and a growing suite ... the platform for these and future publicly available resources ...
(Date:4/3/2017)... WASHINGTON , April 3, 2017 /PRNewswire-USNewswire/ ... single-cell precision engineering platform, detected a statistically ... cell product prior to treatment and objective ... highlight the potential to predict whether cancer ... prior to treatment, as well as to ...
(Date:3/29/2017)... the health IT company that operates the largest health ... today announced a Series B investment from BlueCross BlueShield ... investment and acquisition accelerates higi,s strategy to create the ... activities through the collection and workflow integration of ambient ... secures data today on behalf of over 36 million ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... June 22, 2017 , ... Charm Sciences, Inc. is pleased to announce ... determined to be appropriate as a screening test at dairies and farms for raw ... system, and the Charm EZ Lite system. These systems are a combination incubator and ...
(Date:6/20/2017)... ... 20, 2017 , ... HorizonScan is providing food and ingredient ... likely threat to their products at the annual IFT conference in Las Vegas, ... expo attracts over 20,000 attendees representing food science professionals from over 90 countries ...
(Date:6/20/2017)... ... 20, 2017 , ... Do More with OHAUS , With the launch of ... in the weighing industry, to extending its expertise across the entire laboratory to a ... and more, allowing for its customers to 'Do More' in the lab. ...
(Date:6/19/2017)... ... June 19, 2017 , ... EDETEK, Inc., ... today that it is launching two new additions of its award-winning cloud-based platform ... capabilities at the DIA 2017 Annual Meeting in Chicago, IL, June 19-22, 2017. ...
Breaking Biology Technology: