Navigation Links
Specific brain protein required for nerve cell connections to form and function
Date:9/5/2007

CHAPEL HILL Neurons, or nerve cells, communicate with each other through contact points called synapses. When these connections are damaged, communication breaks down, causing the messages that would normally help our feet push our bike pedals or our mind locate our car keys to fall short.

Now scientists at the University of North Carolina at Chapel Hill School of Medicine have shown that a protein called neurexin is required for these nerve cell connections to form and function correctly.

The discovery, made in Drosophila fruit flies may lead to advances in understanding autism spectrum disorders, as recently, human neurexins have been identified as a genetic risk factor for autism.

"This finding now gives us the opportunity to see what job neurexin performs within the cell, so that we can gain a better insight into what can go wrong in the nervous system when neurexin function is lost said Dr. Manzoor Bhat, associate professor of cell and molecular physiology in the UNC School of Medicine and senior author of the study.

The study, published online September 6, 2007, in the journal Neuron, is the first to successfully demonstrate in a Drosophila model the consequences that mutating this important protein may have on synapses.

The research was supported in part by grants from the National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke and the National Institute of Mental Health and funds from the state of North Carolina.

During the last decade, scientists have learned that neurexins are integral to the transmission of chemical signals within the nervous system. Neurexins interact with binding partners called neuroligins to link neighboring nerve cells together so that signals can be sent and received correctly.

Previous attempts to study these proteins in animal models have been challenging. In vertebrates such as mice, three different genes code
'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-843-9687
University of North Carolina at Chapel Hill
Source:Eurekalert

Page: 1 2

Related biology news :

1. Products containing specific probes for detecting alternative splice forms protected
2. Scientists generate patient-specific stem cells, Science study says
3. Identification of specific genes predicts which patients will respond to Hepatitis C treatment
4. Eating, body weight regulated by specific neurons
5. Tool developed to silence genes in specific tissues using RNAi
6. Gene-specific Ebola therapies protect non-human primates from lethal disease
7. Unique dual target specificity of kinase inhibitor key for success against cancer
8. Serotonin, acting in a specific brain region, promotes sleep in fruit flies
9. A new male-specific gene in algae unveils an origin of male and female
10. Scientists identify specific enzymes that make meningitis hard to fight
11. Sun exposure early in life linked to specific skin cancer gene mutation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... , March 24, 2015   NexID Biometrics ... critical security-authentication needs, today announced the beginning of shipments ... solution. The company, based in ... the three-day Connect:ID Expo, which began here today at ... said version 2.0 of its SDK boosts the accuracy ...
(Date:3/23/2015)... 2015   HOYOS Labs , a leading global ... that the Company will demonstrate multiple biometrics-based technologies under ... at Connect:ID on March 23 through 25, 2015, in ... highlight the IEEE Biometric Open Protocol Standard; free biometrics-based ... access control system. BOPS was invented by HOYOS Labs ...
(Date:3/20/2015)... 2015 Research and Markets ( ... "India Sensors Market Forecast and Opportunities 2020" ... sensor market is projected to grow at a ... electronics, automotive, industrial and healthcare sectors are the ... In addition, adoption of MEMS technology in sensors ...
Breaking Biology News(10 mins):NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3
... and other institutions declare that improvements in management ... the number of tigers currently existing in the region. ... the most recent edition of the journal Biological Conservation. ... Indian subcontinentcomprising India, Bangladesh, Bhutan, and Nepal. It found ...
... Topics include: continental deformation and the San Andreas ... rocks between Britain and America; environmental stress and ... in Canada,s Mackenzie River basin as a CO2 ... in the absence of active volcanism; and geologic ...
... a lot about you. Now, scientists say that the ... likely reveals a lot about you and your brain, too. ... Center, worms that are hermaphrodites (with characteristics of both females ... the other of the two sexes in these worms ...
Cached Biology News:WCS study finds potential to double tiger numbers in South Asia 2November GEOLOGY and GSA TODAY Media Highlights 2November GEOLOGY and GSA TODAY Media Highlights 3November GEOLOGY and GSA TODAY Media Highlights 4November GEOLOGY and GSA TODAY Media Highlights 5November GEOLOGY and GSA TODAY Media Highlights 6November GEOLOGY and GSA TODAY Media Highlights 7November GEOLOGY and GSA TODAY Media Highlights 8November GEOLOGY and GSA TODAY Media Highlights 9November GEOLOGY and GSA TODAY Media Highlights 10Worms take the sniff test to reveal sex differences in brain 2Worms take the sniff test to reveal sex differences in brain 3
(Date:5/4/2015)... Genedata, a leading provider of advanced ... research, today announced the release of Genedata ... enterprise solution for biologics R&D. This first-in-class workflow ... and development of novel biotherapeutics. Version 5.0 enables ... optimization and developability requirements. Genedata will present highlights ...
(Date:5/4/2015)... 4, 2015 China Cord Blood Corporation (NYSE: ... China,s leading provider of cord blood collection, ... storage services, today announced that the Company has been ... Hong Kong listed company and ... an agreement (the "Agreement") to purchase the Company,s outstanding ...
(Date:5/4/2015)... 2015   Intrexon Corporation (NYSE: XON ... financial results after the market closes on May 11, ... day at 5:30 PM ET to discuss the results ... conference call may be accessed by dialing 1-888-346-3959 (Domestic ... "Intrexon Conference Call."  Participants may also access the live ...
(Date:5/1/2015)... , May 1, 2015  Northwest Biotherapeutics (NASDAQ: ... DCVax® personalized immune therapies for solid tumor cancers, announced ... million second tranche of a $40 million investment from ... Woodford first invested $25 million in NW Bio on ... into an agreement with the Company for a further ...
Breaking Biology Technology:Genedata Biologics 5.0 – Antibody Engineering and Developability Assessment Advances 2Genedata Biologics 5.0 – Antibody Engineering and Developability Assessment Advances 3Genedata Biologics 5.0 – Antibody Engineering and Developability Assessment Advances 4China Cord Blood Corporation Receives Notice of a Transaction Regarding its 7% Senior Convertible Notes Due 2017 Held by KKR 2China Cord Blood Corporation Receives Notice of a Transaction Regarding its 7% Senior Convertible Notes Due 2017 Held by KKR 3Intrexon to Announce First Quarter 2015 Financial Results on Monday, May 11, 2015 2NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 2NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 3
... about IT project failure rates. Youve probably heard mention of ... poor requirements and scope definition, lack of business relevance or ... of this hand wringing is the real root cause. Its ... For each one, the source is the failure of specific ...
... Welcome to the global village called BIO 03. Lets ... , ,Starting at the Wisconsin Pavilion in the cavernous exhibit ... 100 the anniversary Harley-Davidson motorcycle parked in the corner. OK, ... its a great way to lure people into our aisle. ...
... Note: The Wisconsin Technology Council has published ... The 24-page publication highlights the states research base, ... contacts and the I-Q Corridor that joins Chicago, ... Technology Network has arranged to post excerpts from ...
Cached Biology Technology:Analog people in the digital revolution 2Analog people in the digital revolution 3On Location at BIO 2003 2Life Science: From the arts to the outdoors: Living and Playing in Wisconsin 2Life Science: From the arts to the outdoors: Living and Playing in Wisconsin 3Life Science: From the arts to the outdoors: Living and Playing in Wisconsin 4Life Science: From the arts to the outdoors: Living and Playing in Wisconsin 5
Melanoma Antigen, Family C, 1 (MAGEC1) Rabbit anti-Human Polyclonal Antibody Immunogen: Synthetic peptide - KLH conjugated Family: New Recommended Storage: Long term: -20C; Short term: +4...
...
ECE-1 (H-60)...
Mouse monoclonal [AE3] to Cytokeratin 1 - 8, prediluted ( Abpromise for all tested applications). Antigen: Tissue / cell preparation - Human epidermal cells. Entrez GeneID: 140807 Swiss P...
Biology Products: