Navigation Links
Specific blood-derived cells promote survival in heart attack model
Date:6/16/2010

Tampa, Fla. (June 16, 2010) A research team from McGill University (Canada) report a beneficial effect on cardiac function in mouse models when implanted monocytes - a type of white blood cell that is part of the immune system - helped preserve cardiac function following a heart attack (myocardial infarction).

Their study, published in the current issue of Cell Transplantation (19:4), is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/.

With heart failure a leading cause of morbidity and mortality, improving post-myocardial infarction therapies through natural adaptive responses, such as finding ways to boost and use the immune system, is an important area of research.

Monocytes, produced in the bone marrow, circulate in the bloodstream for a few days before moving to tissues throughout the body and play a role in attacking foreign substances in the body, including infection.

New blood vessel growth (angiogenesis) could play an important role in the repair of damaged heart tissue. The researchers therefore chose to grow (culture) monocytes, derived from mouse blood, under angiogenic conditions prior to transplantation to determine if these so-called monocyte derivatives could be beneficial.

"Our purpose was to assess the effect of monocyte derivatives (MDs) on cardiac and endothelial cell proliferation and survival," said the study's lead author Dr. Jacques Galipeau, associate professor of medicine at McGill University's Lady Davis Institute for Medical Research. "In this study, we demonstrated that myocardial protection following infarction can be induced in part by growth factors released by MDs. This finding strongly suggests that these released proteins reduce cardiac cell apoptosis and enhance endothelial cell proliferation in vitro, and reduce fibrosis in vivo."

The McGill researchers found that when
'/>"/>

Contact: David Eve
celltransplantation@gmail.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Page: 1 2

Related biology news :

1. Specific brain protein required for nerve cell connections to form and function
2. St. Jude identifies the specific cell that causes eye cancer, disproving long-held theory
3. Foods, not specific nutrients, may be key to good health
4. The key to unlocking the secret of highly specific DNAzyme catalysis
5. First-ever study to link increased mortality specifically to carbon dioxide emissions
6. Its a unisex brain with specific signals that trigger male behavior
7. Oocyte-specific gene mutations cause premature ovarian failure
8. New paradigm for cell-specific gene delivery
9. Carnegie Mellon MRI technology that non-invasively locates, quantifies specific cells in the body
10. Researchers seeking to identify Alzheimers risk focus on specific blood biomarker
11. Study reveals specific gene in adolescent men with delinquent peers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2015)... SPRINGVILLE, Utah , June 26, 2015 ATL ... assemblies and devices with specialties in single use solutions, headquartered ... acquisition of MedConx, Inc. (a California ... , and San Jose, Costa Rica ). ... Costa Rica with ATL Technology,s existing ...
(Date:6/24/2015)... 2015 This report provides market analysis of ... years. It contains an analysis of the drivers, challenges, ... impact from the short, medium, and long term perspective ... market, and technology trends that currently, prevail in the ... authorities to efficiently manage the increasing marine traffic and ...
(Date:6/23/2015)... June 22, 2015 ... addition of the "Body-Worn Temperature Sensors Market ... and Forecast 2014 - 2020" report to ... analysis of the global body-worn temperature sensors market. ... segmented on the basis of types, care setting, ...
Breaking Biology News(10 mins):ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2Automatic Identification System Market by Class, by Platform, by Application and by Geography - Global Forecasts & Analysis to 2014 - 2020 2Body-Worn Temperature Sensors Market - Global Industry Analysis 2
... frequently arise between individuals from different cultures. But what ... another less so? A new international study led ... National Science Foundation,s Division of Behavioral and Cognitive Sciences ... and bridge the gaps between them. Published in ...
... Biodesign Institute at Arizona State University research team has ... producing low-cost, renewable biofuels from bacteria. The team ... byproduct recovery and conversion to biofuels easier and potentially ... in any biofuel production are harvesting the goodies and ...
... door in your backyard, a vacant lot next door ... the week of this year,s summer solstice, June 18-24, people ... natural environment as part of the first Nearby Nature GigaBlitz. ... at Carnegie Mellon University,s CREATE Lab, the GigaBlitz would involve ...
Cached Biology News:World-wide assessment determines differences in cultures 2World-wide assessment determines differences in cultures 3Green and lean: Secreting bacteria eliminate cost barriers for renewable biofuel production 2Green and lean: Secreting bacteria eliminate cost barriers for renewable biofuel production 3GigaBlitz will turn high-resolution images of nature into global inventory of organisms, habitats 2
(Date:6/29/2015)... -- Neuralstem, Inc. (NYSE MKT: CUR), a biopharmaceutical company using ... cell therapy treatments for central nervous system diseases, announced ... the NASDAQ Capital Market under the symbol "CUR." The ... NYSE MKT until the market close on July 10, ... to commence on July 13, 2015. ...
(Date:6/29/2015)... ... June 29, 2015 , ... The StampedeCon ... and for the fourth year in a row, will bring top technology professionals to ... place at the intersection of data and technology. The event is proudly sponsored by ...
(Date:6/29/2015)... YORK , June 29, 2015   For the ... life sciences to assess their overall digital maturity called ... show that these companies are not maturing fast enough. ... healthcare industry in numerous ways overall and customers are ... in terms of digital customer engagement.  ...
(Date:6/26/2015)... MILFORD, Mass. , June 26, 2015 /PRNewswire/ ... in vitro diagnostics manufacturers, today announced that it ... (CRADA) with the National Cancer Institute (NCI), part ... reference materials and positive controls for cancer assays. ... to mix and accurately quantitate control DNA biosynthetics ...
Breaking Biology Technology:Neuralstem, Inc. Announces Approval for Listing on the NASDAQ Capital Market 2Neuralstem, Inc. Announces Approval for Listing on the NASDAQ Capital Market 3StampedeCon Announces 2015 Agenda 2StampedeCon Announces 2015 Agenda 3Results from Digital Maturity Study Show Pharma Lagging 2Results from Digital Maturity Study Show Pharma Lagging 3Results from Digital Maturity Study Show Pharma Lagging 4SeraCare Life Sciences Signs CRADA with NCI to Advance Cancer Diagnostics 2SeraCare Life Sciences Signs CRADA with NCI to Advance Cancer Diagnostics 3
... Sinai School of Medicine of New York University ... are integral in the development of atherosclerotic lesions, however ... of atherosclerotic plaque. This application note describes a protocol ... RT-PCR to selectively analyze RNA from foam cells of ...
... Key words: serotonin ... LEADseeker • SPA Imaging Beads , ... (5-hydroxytryptamine, 5-HT) is a regulator of neural transmission which induces its biological ... receptor is a subtype of the serotonin receptor that belongs to ...
... , ... • LEADseeker , ... organizations to continually increase screening throughput. Yet accuracy and sensitivity remain ... Multimodality Imaging System was developed to meet these demands by combining ...
Cached Biology Technology:Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions 2Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions 3Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions 4Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions 5Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions 6Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions 7Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions 8Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions 9Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions 10Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions 11The development of a serotonin 5-HT2C receptor-binding assay using the LEADseeker Multimodality Imaging System 2The development of a serotonin 5-HT2C receptor-binding assay using the LEADseeker Multimodality Imaging System 3The development of a serotonin 5-HT2C receptor-binding assay using the LEADseeker Multimodality Imaging System 4Use of the HitHunter EFC Chemiluminescent Detection Kits with LEADseeker Multimodality Imaging System 2Use of the HitHunter EFC Chemiluminescent Detection Kits with LEADseeker Multimodality Imaging System 3Use of the HitHunter EFC Chemiluminescent Detection Kits with LEADseeker Multimodality Imaging System 4