Navigation Links
Specific blood-derived cells promote survival in heart attack model
Date:6/16/2010

Tampa, Fla. (June 16, 2010) A research team from McGill University (Canada) report a beneficial effect on cardiac function in mouse models when implanted monocytes - a type of white blood cell that is part of the immune system - helped preserve cardiac function following a heart attack (myocardial infarction).

Their study, published in the current issue of Cell Transplantation (19:4), is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/.

With heart failure a leading cause of morbidity and mortality, improving post-myocardial infarction therapies through natural adaptive responses, such as finding ways to boost and use the immune system, is an important area of research.

Monocytes, produced in the bone marrow, circulate in the bloodstream for a few days before moving to tissues throughout the body and play a role in attacking foreign substances in the body, including infection.

New blood vessel growth (angiogenesis) could play an important role in the repair of damaged heart tissue. The researchers therefore chose to grow (culture) monocytes, derived from mouse blood, under angiogenic conditions prior to transplantation to determine if these so-called monocyte derivatives could be beneficial.

"Our purpose was to assess the effect of monocyte derivatives (MDs) on cardiac and endothelial cell proliferation and survival," said the study's lead author Dr. Jacques Galipeau, associate professor of medicine at McGill University's Lady Davis Institute for Medical Research. "In this study, we demonstrated that myocardial protection following infarction can be induced in part by growth factors released by MDs. This finding strongly suggests that these released proteins reduce cardiac cell apoptosis and enhance endothelial cell proliferation in vitro, and reduce fibrosis in vivo."

The McGill researchers found that when they transplanted the MDs into animal models of myocardial infarction, the cells secreted high levels of a variety of growth factors that provided anti-inflammatory properties and also played a role in protecting cells of the heart tissues (cardiomyocytes) from programmed cell death (apoptosis).

The researchers also noted that the majority of MDs did not survive more than two weeks in vitro, suggesting that the cells have an effect shortly after injection.

"Dr. Galipeau's group have clearly demonstrated a beneficial effect of the MDs on myocardial improvement in the post-myocardial infarction remodeling process," said Amit N. Patel, director of cardiovascular regenerative medicine at the University of Utah and section editor for Cell Transplantation." These results further demonstrate the benefits of bone marrow derived cells for cardiac cell therapy."


'/>"/>

Contact: David Eve
celltransplantation@gmail.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related biology news :

1. Specific brain protein required for nerve cell connections to form and function
2. St. Jude identifies the specific cell that causes eye cancer, disproving long-held theory
3. Foods, not specific nutrients, may be key to good health
4. The key to unlocking the secret of highly specific DNAzyme catalysis
5. First-ever study to link increased mortality specifically to carbon dioxide emissions
6. Its a unisex brain with specific signals that trigger male behavior
7. Oocyte-specific gene mutations cause premature ovarian failure
8. New paradigm for cell-specific gene delivery
9. Carnegie Mellon MRI technology that non-invasively locates, quantifies specific cells in the body
10. Researchers seeking to identify Alzheimers risk focus on specific blood biomarker
11. Study reveals specific gene in adolescent men with delinquent peers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/29/2016)... , November 29, 2016 Nearly one billion ... Continue Reading ... ... part of an efficient Identity Management. (PRNewsFoto/DERMALOG Identification Systems) ... DERMALOG is Germany's largest Multi-Biometric supplier: The ...
(Date:11/22/2016)... 2016   MedNet Solutions , an innovative SaaS-based ... clinical research, is pleased to announce that the company ... Life Sciences Awards as "Most Outstanding in eClinical ... year of recognition and growth for MedNet, which has ... iMedNet ™ , MedNet,s flagship ...
(Date:11/17/2016)... , Nov. 17, 2016  AIC announces that it has just released a new ... that require high-performance scale-out plus high speed data transfer storage solutions. Photo ... ... ... Setting up a high performance computing ...
Breaking Biology News(10 mins):
(Date:11/30/2016)... ... November 30, 2016 , ... BEI Kimco, a ... with a flexure design that ensures high alignment accuracy by preventing unwanted shaft ... ideally suited where extreme precision is required, such as in medical equipment, laboratory ...
(Date:11/30/2016)...  The Allen Institute for Cell Science has ... available collection of gene edited, fluorescently tagged human ... structures with unprecedented clarity. Distributed through the Coriell ... a crucial first step toward visualizing the dynamic ... human cells healthy and what goes wrong in ...
(Date:11/30/2016)... Part of 5m$ Investment in Integrated Drug Discovery ... , ... announced that it had successfully completed the expansion of their ... the Screening Collection to over 400,000. The new compounds were ... company. This expansion, complemented by new robotics and compound management ...
(Date:11/30/2016)... (PRWEB) , ... November 30, 2016 , ... On 28 ... and symbols for four elements: nihonium (Nh), moscovium (Mc), tennessine (Ts), and oganesson ... of public review, the names earlier proposed by the discoverers have been approved by ...
Breaking Biology Technology: