Navigation Links
Species diversity helps ASU researchers refine analyses of human gene mutations
Date:9/3/2009

ow that humans display a striking degree of genetic similarity with many other species, particularly non-human primates like chimpanzees, gibbons, gorillas and orangutans, with whom we share over 98 percent of our genes. "Comparative genomics provides the first clues as to what a mutation might mean," says Kumar. "This is an area that is going to become center stage in personal genomics and medicine."

Techniques in this rapidly expanding field make use of existing Web databanks such as GenBank, which contains more than 100 billion DNA and protein sequence elements collected from all walks of life. "These databases already contain the outcomes of nature's experiment, which we can harness by using bioinformatics," says Kumar.

DNA medicine typically uses a suite of computer tools to assess whether a newly discovered protein change is potentially disease-causing or benign. Kumar's study tested the reliability of two of the most widely-used tests, known as SIFT and PolyPhen, by examining over 20,000 mutations from both diagnosed patients and healthy individuals. The results demonstrate that these tests make false predictions of risk up to 40 percent of the time, a rate of reliability that renders them impractical for clinical use.

The objective of the study was to identify where SIFT and PolyPhen tend to fail and where their predictions appear to be more reliable. To accomplish this, Kumar's group examined the proteins in 44 species, from frogs to fish, chimps and gorillas. His group discovered that benign mutations tend to occur in regions of the genome that allow variation over evolutionary time across species. In these regions, it is easier to make accurate predictions of benign mutations.

In contrast, DNA information essential for life is persistent from species to species. Many DNA positions permit no change over evolutionary time in order to preserve proper functionmutations here would likely be damaging. Reinforc
'/>"/>

Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-727-0369
Arizona State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Global warming threatens tropical species, the ecosystem and its by-products
2. Scientists discover new species of crustacean on Lanzarote
3. Genome duplication responsible for more plant species than previously thought
4. Beautiful plumage: Feather color and sex start the species revolution
5. Red List overlooks island species
6. A global model for the origin of species independent of geographical isolation
7. Mystery E. coli genes essential for survival of many species
8. US-Mexico border wall could threaten wildlife species
9. Common fish species has human ability to learn
10. Sands of Gobi Desert yield new species of nut-cracking dinosaur
11. New species of phallus-shaped mushroom named after California Academy of Sciences scientist
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... from shale rock has increased by more than ... not fully understand the industry,s effects on nature ... journal Frontiers in Ecology and the Environment ... outpace scientific examination, a team of eight conservation ... University, concluded that determining the environmental impact of ...
(Date:7/31/2014)... decade ago, prestin was found to be a key gene ... found in the hair cells of the inner ear that ... cochlea, like an antique phonograph horn, amplify sound waves to ... study published in the advanced online edition of Molecular ... that prestin has also independently evolved to play a critical ...
(Date:7/31/2014)... study of bigeye tuna movements in the northwestern Atlantic ... Pelagics Research Center at the University of Massachusetts Amherst, ... wide geographical range with pronounced north-south movements from Georges ... high-use area off Cape Hatteras southwest of Bermuda for ... approach to study one of the most important commercial ...
Breaking Biology News(10 mins):'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 2'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 3Study of bigeye tuna in Northwest Atlantic uses new tracking methods 2Study of bigeye tuna in Northwest Atlantic uses new tracking methods 3
... COLUMBIA, Mo. With the obesity rate rising for ... and cardiovascular disease are a frequent reality. Although obesity ... of the threat may be associated with a cluster ... weight can improve health and reduce these risk factors, ...
... was celebrated last year as a possible "missing link" between ... lemurs and lorises, according to two papers by scientists at ... University of Chicago. In an article now available online ... present evidence that the 47-million-year-old Darwinius masillae is ...
... American Society for Microbiology (ASM) BD Award for ... J. Stephen Dumler, M.D., Professor, The Johns Hopkins ... BD Diagnostic Systems, this award recognizes a distinguished ... for important applications in clinical microbiology. Dumler,s ...
Cached Biology News:Exercise counters negative effects of weight regain, researchers find 2Recently analyzed fossil was not human ancestor as claimed, anthropologists say 2Recently analyzed fossil was not human ancestor as claimed, anthropologists say 3American Society for Microbiology honors J. Stephen Dumler 2
(Date:7/31/2014)... (PRWEB) July 31, 2014 North Shore Towers, ... City, partnered with GI Energy, one of the nation’s leading ... $13 million upgrade of its 43-year-old CHP system. The original ... in an effort to extend the life of the plant, ... and associated electrical and heat recovery equipment, while maintaining continuous ...
(Date:7/31/2014)... 2014  Smith & Nephew (LSE:SN, NYSE: ... today announced its entry into the forefoot market ... Repair System. Comprised of three separate repair options, ... ligament repair and reconstruction, a metatarsal osteotomy guide, ... (PIP) fusion, also known as hammer toe correction. ...
(Date:7/31/2014)... July 31, 2014 Although RNA-Sequencing ... the first transcriptome-wide analyses appearing around 2008, RNA-Sequencing ... for RNA measurement. In the last several years, ... specific, work with smaller input amounts, process degraded ... blood samples). On the bioinformatics side, there have ...
(Date:7/31/2014)... Boston, MA (PRWEB) July 31, 2014 ... ) finds itself flush with innovative adult stem cell ... patents and has three additional patent applications ... Office. , The patented inventions address two of the ... and regenerative medicine. Adult stem cells are difficult ...
Breaking Biology Technology:North Shore Towers Partners with GI Energy to Install Turnkey Natural Gas-Fired Combined Heat and Power Plant 2Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 2Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 3Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 4The Evolution of RNA-Sequencing, Upcoming Live Webinar August 22 hosted by Xtalks 2The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 2The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 3
... Contributed by Jacqueline Boultwood, Gail M. Abrahamson, and J.,S. Wainscoat, Leukemia ... 9DU, United Kingdom , ... , Tumor diagnoses, ... non-invasive manner. For,example, peripheral blood may be used as a source ...
... , ... USA , , ... Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) , ... this traditional gel-based method involves multiple manual steps and several , ...
... , , ... has traditionally been a fast but inefficient method , ... buffer system, transfer efficiency can be greatly increased. In protein , ... of the proteins , from a gel and the ...
Cached Biology Technology:PFGE Analysis of Chromosomal DNA From a Single Hair Root 2Performance Comparison of the Experion Automated Electrophoresis System and a Competing Automated System for Protein Analysis, Rev A 2Performance Comparison of the Experion Automated Electrophoresis System and a Competing Automated System for Protein Analysis, Rev A 3Performance Comparison of the Experion Automated Electrophoresis System and a Competing Automated System for Protein Analysis, Rev A 4Performance Comparison of the Experion Automated Electrophoresis System and a Competing Automated System for Protein Analysis, Rev A 5Performance Comparison of the Experion Automated Electrophoresis System and a Competing Automated System for Protein Analysis, Rev A 6Performance Comparison of the Experion Automated Electrophoresis System and a Competing Automated System for Protein Analysis, Rev A 7Performance Comparison of the Experion Automated Electrophoresis System and a Competing Automated System for Protein Analysis, Rev A 8Performance Comparison of the Experion Automated Electrophoresis System and a Competing Automated System for Protein Analysis, Rev A 9Performance Comparison of the Experion Automated Electrophoresis System and a Competing Automated System for Protein Analysis, Rev A 10Performance Comparison of the Experion Automated Electrophoresis System and a Competing Automated System for Protein Analysis, Rev A 11Performance Comparison of the Experion Automated Electrophoresis System and a Competing Automated System for Protein Analysis, Rev A 12Performance Comparison of the Experion Automated Electrophoresis System and a Competing Automated System for Protein Analysis, Rev A 13Increased Transfer Efficiency Using a Discontinuous Buffer System With the Trans-Blot SD Cell 2Increased Transfer Efficiency Using a Discontinuous Buffer System With the Trans-Blot SD Cell 3Increased Transfer Efficiency Using a Discontinuous Buffer System With the Trans-Blot SD Cell 4
... DTT White crystalline solid. PACKAGED ... titration. Contaminants: DNases, proteases, RNases: ... 260 nm): ≤0.500; (100 mM, 1 cm, ... ≤0.001%. Soluble in H 2 O. ...
... (hemagglutinating virus of Japan, also named Sendai ... for transfection of molecules by means of ... siRNA (RNAi), Protein, Oligo, cDNA, Antibodies, Vector, ... vivo. GenomONE-Neo EX has a high fusing ...
... Dithiothreitol DTT ... INERT GAS. Purity: ≥99% ... metals: Absorbance: (100 ... Soluble in EtOH or H ...
... Dithiothreitol DTT White ... reduces disulfides to thiols, so reaction is "driven" ... Does not contain waxy surfactant found in many ... of pentobarbitol. Purity: ≥97% by titration. ...
Biology Products: