Navigation Links
Species diversity helps ASU researchers refine analyses of human gene mutations
Date:9/3/2009

In the new era of personalized medicine, physicians hope to provide earlier diagnoses and improve therapy by evaluating patients' genetic blueprints. But, as a new bioinformatics study emphasizes, the first step must be to correctly decipher the deluge of information locked in our DNA and determine its impact on human health.

In the September issue of Genome Research, Dr. Sudhir Kumar led a team of researchers at the Biodesign Institute at Arizona State University in examining DNA mutations from both healthy and diseased patients. Their work evaluates the reliability of computer models aimed at predicting the eventual effect of such mutations.

Along with Kumar, director of the Biodesign Institute's Center for Evolutionary Functional Genomics, others involved with the study were co-authors Michael P. Suleski, Glenn J. Markov, Simon Lawrence, Antonio Marco and Alan J. Filipski.

Kumar's team focused on single DNA mutationschanges to a person's genome that can sometimes make the difference between robust health and debilitating illness. The current study focused on one specific type of DNA mutationa single change at a given location along the length of DNAthat alters the resulting protein. These protein changes are the source of much of our individuality, coding for differences such as eye and hair color. Scientists have discovered that each person's genome contains thousands of such protein changes. Other single mutations, however, are linked with severe illnesses like cystic fibrosis.

While experimentation on the enormous number of mutations across human populations is impractical due to volume and cost, Mother Nature, as Kumar points out, has already done an experiment for us, presenting scientists with a set of benign mutations for each protein. The branch of science known as comparative genomics takes advantage of the genetic information collected from the diversity of life on Earth.

We now kn
'/>"/>

Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-727-0369
Arizona State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Global warming threatens tropical species, the ecosystem and its by-products
2. Scientists discover new species of crustacean on Lanzarote
3. Genome duplication responsible for more plant species than previously thought
4. Beautiful plumage: Feather color and sex start the species revolution
5. Red List overlooks island species
6. A global model for the origin of species independent of geographical isolation
7. Mystery E. coli genes essential for survival of many species
8. US-Mexico border wall could threaten wildlife species
9. Common fish species has human ability to learn
10. Sands of Gobi Desert yield new species of nut-cracking dinosaur
11. New species of phallus-shaped mushroom named after California Academy of Sciences scientist
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... from Salk Institute for Biological Studies, BGI, and ... safety and reliability of the existing targeted gene ... TALEN-HDAdV, which could significantly increased gene-correction efficiency in ... published online in Cell Stell Cell ... gene therapy. , The combination of stem cells ...
(Date:7/11/2014)... University, Sweden, have explored two different ways that ... leading to the formation of oxygen molecules in ... the scientific journal Nature Communications . , ... synthetic catalysts for water oxidation, which are key ... direct storage of solar energy in fuels like ...
(Date:7/11/2014)... has demonstrated that transplantation of mesenchymal stem cells can ... mouse models of Alzheimer,s disease (AD) and improve tissue ... Few studies are reported on the therapeutic effect of ... and on the effect on oxidative injury and neurogenesis ... and her team, School of Life Sciences, Tsinghua University, ...
Breaking Biology News(10 mins):A new genome editing method brings the possibility of gene therapies closer to reality 2Molecular snapshots of oxygen formation in photosynthesis 2
... Aware, Inc. (Nasdaq: AWRE ), a leading technology ... scheduled a conference call to discuss the company,s operating results ... February 3, 2011, at 5:00 p.m. Eastern Time. President and ... earnings conference call. This call is being webcast ...
... HARBIN, China, Feb. 1, 2011/PRNewswire-Asia-FirstCall/ -- Weikang Bio-Technology ... WKBT ) ("Weikang" or the "Company"), a leading ... (TCM), Western prescription and OTC pharmaceuticals and other ... of China, today announced the completion of its ...
... SANDY, Utah, Feb. 9, 2011 Qqest and M2SYS ... announced a partnership that allows Qqest to offer TimeForce ... features of biometric identification technology at their PC. ... biometric platform technology to seamlessly interface with Qqest,s ...
Cached Biology News:Aware, Inc. Announces Q4 and FY2010 Earnings Conference Call 2Weikang Bio-Technology Announces Completion of $5.0 Million Private Placement 2Weikang Bio-Technology Announces Completion of $5.0 Million Private Placement 3Qqest Teams Up With M2SYS to Add Biometric Technology at the Desktop to TimeForce Time and Attendance System 2Qqest Teams Up With M2SYS to Add Biometric Technology at the Desktop to TimeForce Time and Attendance System 3
(Date:7/10/2014)... Robert Harman, DVM, Founder and CEO of Vet-Stem, Inc., the ... relaunch of his highly informative blog, now named Stem Cells ... are Stem Cells ?” Dr. Harman’s purpose for blogging ... basics of stem cell therapy so that pet owners can ... when considering regenerative medicine. , A veterinarian by trade, Dr. ...
(Date:7/10/2014)... , July 10, 2014  Franciscan ... use of capnography for respiratory monitoring outside ... of healthcare leaders in embracing state-of-the-art patient ... effectively patients are breathing and can alert ... By measuring the amount of carbon dioxide ...
(Date:7/10/2014)... DUBLIN , July 10, 2014 ... the addition of the "International Photonic Integrated ... - Forecasts to 2019" report to their ... The concept of photonic integration traces ... twentieth century. The promise of photonic integration went ...
(Date:7/10/2014)... 17, 2014 Using microscopic polymer light resonators ... researchers at MIT,s Quantum Photonics Laboratory have developed ... the parts-per-billion range. Optical sensors are ideal for ... signal-to-noise ratio, compact, lightweight nature, and immunity to ... had been developed before, the MIT team conceived ...
Breaking Biology Technology:Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Swell new sensors 2
... Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) and ... how the botulinum neurotoxin, a potential bioterrorism agent, survives ... through the human body. Their study, published February 24 ... of a neurotoxin together with its bodyguard, a protein ...
... The condensation of water is crucial to the operation of ... they are fueled by coal, natural gas or nuclear fuel. ... salty or brackish water. But there are still large gaps ... the surfaces used to turn steam back into water in ...
... 23, 2012 Springboard Enterprises has over a ... by women to potential investors and corporate partners. ... community-driven accelerator designed to fast track the growth ... healthcare IT companies from around the world. The ...
Cached Biology Technology:Disarming the botulinum neurotoxin 2Disarming the botulinum neurotoxin 3Making droplets drop faster 2Making droplets drop faster 3The Search Is On for the Next Big Life Science Innovation 2The Search Is On for the Next Big Life Science Innovation 3
... Jouan RC10 series of vacuum concentrators/centrifugal evaporators ... features allied to rapid and safe concentration ... be combined with oil-free or high vacuum ... a wide selection of rotors (eliminating sample ...
... is Thermo Electron's most advanced personal gradient ... to use sophisticated onboard software and a ... to offer performance, accuracy and simplicity in ... of customer driven features built up on ...
Carrier Serum...
A robust formulation of Taq Polymerase supplied with a 10X colored reaction buffer which allows Direct Gel-Loading...
Biology Products: