Navigation Links
Specialised germanium surface as universal protein adapter
Date:3/8/2013

loped surface remains stable", Jonas Schartner says.

Chemical modular system

As in a modular system, the researchers placed various molecular layers, one above the other, on the germanium crystal. First, they produced hydroxyl groups on the germanium surface, each consisting of an oxygen atom and a hydrogen atom. The product is referred to as activated germanium. The next layer was formed by a new kind of triethoxysilanes, a hydrocarbon compound, which the RUB team produced itself. The researchers anchored one end of the triethoxysilanes covalently to the germanium, i.e. via an electron-pair bond. They converted the other end into a protein trap. All the proteins that carry a particular adapter, the His-tag, can be attached to this. "There are already a lot of proteins available with this universal adapter" Carsten Ktting says.

Modifying the germanium surface in a controlled manner

Using Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy (XPS), the researchers kept track of what happened when stacking the different layers on the germanium crystal. Together with Prof. Dr. Martin Muhler and Bastian Mei from the Laboratory of Industrial Chemistry, the biophysicists were able to accurately determine the atomic composition of the layers with the XPS. Proteins can also be observed on surfaces using other techniques, such as surface plasmon resonance. "With surface plasmon resonance, the gradual modification of the surface is carried out blindly," Jonas Schartner says. "We've observed each modification step live and thus have very good control over the process."

Functional test for the new process successful

A test confirmed that the newly created surface serves its purpose. The researchers equipped the germanium crystal with the switch protein Ras, which plays an important role in carcinogenesis. There they allowed it to interact with a second molecule that switches Ras on
'/>"/>

Contact: Dr. Carsten Ktting
carsten.koetting@rub.de
49-234-322-4873
Ruhr-University Bochum
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Mutation altering stability of surface molecule in acid enables H5N1 infection of mammals
2. A cooler way to protect silicon surfaces
3. Discovering cell surface proteins behavior
4. Stem cell breakthrough could lead to new bone repair therapies on nanoscale surfaces
5. How the tilt of a cell-surface receptor prevents cancer
6. Numerical study suggests subsea injection of chemicals didnt prevent oil from rising to sea surface
7. Illuminating the no-mans land of waters surface
8. Surface analysis techniques for advanced materials enhance Mazovias research potential
9. Ancient microbes found living beneath the icy surface of Antarctic lake
10. 3dMD Transitions Anatomical Research from 3D-Static to 4D-Movement Surface Imaging
11. Professor publishes on first-ever imaging of cells growing on spherical surfaces
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... DURHAM, N.C. -- A study of dominance in female baboons ... maintain close ties with mom, and to have lots of ... not by size or strength, but by the rank of ... higher-ranked her daughter will be. For this reason, dominance rank ... Females born to high-ranking mothers are guaranteed a good spot ...
(Date:7/30/2014)... University associate professor Andrew S. Mount, performed cutting-edge research ... for novel anti-fouling paint for ships and boats and ... The team,s findings, published in Nature Communications ... that attaches to a wide variety of surfaces using ... an underwater heavy-duty adhesive. , "In previous research, we ...
(Date:7/30/2014)... July 30, 2014 ResearchMoz ... Government Biometric Systems Market 2014-2024   Business Strategies, Industry ... Biometric Systems Market 2014-2024" offers the reader detailed ... the next ten years, alongside potential market opportunities ... forecasts. To view the table of ...
Breaking Biology News(10 mins):Supportive moms and sisters boost female baboon's rank 2Supportive moms and sisters boost female baboon's rank 3Study: Marine pest provides advances in maritime anti-fouling and biomedicine 2Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 2Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 3Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 4Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 5Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 6Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 7Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 8Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 9Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 10
... in the Asian tsunami tragedy should be allowed to ... according to some of the world's leading scientists. , ... of Newcastle upon Tyne, and who set out their ... point to historical records of major coral reef devastation ...
... U.S. ports, a public enemy has infiltrated the nation's borders. ... Cornell University expert, the adult female alien is the only ... States. , The discovery of a single specimen of Sirex ... the nation because the invasive insect species has devastated up ...
... strains of leprosy-causing bacteria has revealed some surprises about ... across the continents by human migrations. The research, led ... in the 13 May issue of the journal Science, ... findings indicate that the world's existing leprosy infections are ...
Cached Biology News:Tsunami-damaged coral reefs should be left to recover naturally, say scientists 2Alien woodwasp, threat to US pine trees, found in N.Y. 2Leprosy genome tells story of human migrations, French researchers report in Science 2Leprosy genome tells story of human migrations, French researchers report in Science 3
(Date:7/31/2014)... 31, 2014 According to a ... for Medical Devices Market (Diagnostic Electrodes - ECG, EEG, ... TENS, Pacemakers, Defibrillators, Electrosurgical and Other Electrodes) - Global ... - 2019," the global electrodes market for medical devices ... is estimated to reach a market worth USD 1,451.2 ...
(Date:7/31/2014)... 2014 Senomyx , Inc. (NASDAQ: ... proprietary taste science technologies to discover, develop, and ... and ingredient supply industries, today reported financial results ... the second quarter with $33.6 million in cash ... the past quarter Senomyx achieved another important milestone ...
(Date:7/31/2014)... Held at the Stanford Cancer Center, the ... the disease and its treatment. Survivors will find information ... as updates on the state-of-the-art with respect to newer ... organizing this educational opportunity,” says KCA CEO Bill Bro, ... colleagues have put together a program that balances the ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 Although ... of the first transcriptome-wide analyses appearing around 2008, ... assay for RNA measurement. In the last several ... more specific, work with smaller input amounts, process ... (eg, blood samples). On the bioinformatics side, there ...
Breaking Biology Technology:Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 2Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 3Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 4Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 5Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 6SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 2SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 3SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 4SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 5SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 6SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 7SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 8SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 9SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 10SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 11SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 12SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 13SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 14SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 15SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 16The Evolution of RNA-Sequencing, Upcoming Live Webinar August 22 hosted by Xtalks 2
... to launch product immediately, NATICK, Mass., April ... today announced that it has received approval for,the ... in Canada. The Company reported that Health Canada,s ... and medical devices, has approved its use. The ...
... Product Pipeline with Increased Investment in ... Research & Development, DEERFIELD, Ill., ... financial results for,the first quarter of 2008, and raised its financial outlook ... of $429 million, a 6,percent increase compared to $403 million in the ...
... April 17 Syngenta today,announced that it will build ... Its focus will be on early-stage evaluation of GM ... soy, in the areas of yield,improvement, drought resistance, disease ... have a global scope and will complement,Syngenta,s biotech research ...
Cached Biology Technology:Boston Scientific Receives Canadian Approval for TAXUS(R) Liberte(R) Stent System 2Boston Scientific Receives Canadian Approval for TAXUS(R) Liberte(R) Stent System 3Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 2Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 3Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 4Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 5Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 6Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 7Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 8Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 9Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 10Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 11Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 12Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 13Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 14Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 15Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 16Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 17Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 18Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 19Syngenta To Build Major Global Biotech Research Center in Beijing, China 2Syngenta To Build Major Global Biotech Research Center in Beijing, China 3
Rat Antibody to Kinase Suppressor Of Ras Recognises the kinase suppressor of Ras (KSR). Immunogen: Recombinant human KSR protein Specificity: human kinase supressor of Ras...
... clone E978 GenBank ... Immunogen : NY-ESO-1 ... mouse ascites with 0.05% ... routinely evaluated by immunoblot ...
Form: Ready to use Applications: Immunohistology-frozen, Immunohistology-paraffin, Western Blot, ELISA...
EnzChek Ultra Xylanase Assay Kit *500 assays*...
Biology Products: